Numerical Investigation of the Effect of Blade Geometry on Blood Trauma in a Centrifugal Blood Pump

Chan, Weng Kong; Wong, Y. W.; Ding, Yong; Chua, Leok Poh; Yu, S. C. M.

doi:10.1046/j.1525-1594.2002.06954.x

Cited by 46 publications

(46 citation statements)

References 12 publications

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“…Previous studies of biomechanical platelet activation have typically modeled platelets as either infinitesimal [22,23,25,[31][32][33] or finite-sized [26,[34][35][36][37][38] particles. In either case, Lagrangian particle tracking of the position and stress histories of individual platelet surrogates in the flow is used.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Platelet Activation Potential in Abdominal Aortic Aneurysms

Hansen

Arzani

Shadden

2015

Journal of Biomechanical Engineering

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Intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAA) has potential implications to aneurysm growth and rupture risk; yet, the mechanisms underlying its development remain poorly understood. Some researchers have proposed that ILT development may be driven by biomechanical platelet activation within the AAA, followed by adhesion in regions of low wall shear stress. Studies have investigated wall shear stress levels within AAA, but platelet activation potential (AP) has not been quantified. In this study, patient-specific computational fluid dynamic (CFD) models were used to analyze stressinduced AP within AAA under rest and exercise flow conditions. The analysis was conducted using Lagrangian particle-based and Eulerian continuum-based approaches, and the results were compared. Results indicated that biomechanical platelet activation is unlikely to play a significant role for the conditions considered. No consistent trend was observed in comparing rest and exercise conditions, but the functional dependence of AP on stress magnitude and exposure time can have a large impact on absolute levels of anticipated platelet AP. The Lagrangian method obtained higher peak AP values, although this difference was limited to a small percentage of particles that falls below reported levels of physiologic background platelet activation.

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Section: Introductionmentioning

confidence: 99%

Mechanical Platelet Activation Potential in Abdominal Aortic Aneurysms

Hansen

Arzani

Shadden

2015

Journal of Biomechanical Engineering

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“…In the past two decades, computational fluid dynamics has been widely used to predict blood damage (Chan et al, 2002;D. De Wachter and Verdonck, 2002;Yun et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Towards computational prediction of flow-induced damage of blood cells using a time-accumulated model

Gharaie

Mosadegh

Morsi

2017

JBSE

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Currently, there is no definite mathematical model to evaluate damage to blood cells, especially for cardiovascular devices with complex flow profiles due to turbulent flow and moving parts. This paper describes a finite volume technique that can more accurately predict damage of red blood cells and platelets by tracking their shear stress history and calculating their accumulated damage. Three standard power-law models for calculating the damage to the blood cells are compared to a novel modified model which takes into account a particle accumulated history and corrects for issues in previous models that miscount for decreasing shear stress. As an example, the damage to blood cells are determined for specific streamlines along a prosthetic polymer-based aortic valve, which is a cardiac device with low levels of damage, allowing for the sensitivity of these models to be tested. The results suggest that the new modified model provides the most accurate prediction of damage.

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“…The cumulative (total) damage to platelets or red blood cells, often referred to as a damage index (DI), can therefore be quantified numerically by summating all sublethal (differential) contributions to blood cell damage [93]. This strategy for determining damage accumulation yields the following equations, commonly found in literature [30,[94][95][96]: (12.8) with τ i being the shear stress value acting during the i th observation interval t i and N the number of time steps from t 0 to time t [93]. The appropriateness of the above power law-based formulations (Equations (12.7) and (12.8)) for predicting red blood cell and platelet lysis under time-varying shear stress has been seriously questioned by Goubergrits [89] and Grigioni et al [97], as neither of these equations incorporates the effect of loading history.…”

Section: Modeling Blood Damagementioning

confidence: 99%

Mechanical Valve Fluid Dynamics and Thrombus Initiation

Claessens

Degroote

Vierendeels

et al. 2010

Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems

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Heart valve, and subsequently cardiac function, may be seriously compromised as a result of stenosis or regurgitation. If necessary, the native heart valve is surgically replaced with an artificial substitute, which is in about 40% of the cases a bileaflet mechanical heart valve (BMHV). While generally showing excellent hemodynamic performance in the short term, current BMHVs are not free of clinical complications, which are induced by thrombus formation and hemolysis. Computational fluid dynamic (CFD) modeling is now considered a powerful and extremely useful tool to investigate blood flow in existing BMHVs and to reduce the costs associated with the development of new prototypes. A prerequisite for performing realistic heart valve simulations is the implementation of a fluid-structure interaction (FSI) algorithm that accounts for the mechanical interaction between the valve leaflets and the ambient blood. Provided the numerical resolution is sufficiently high, three-dimensional CFD-FSI models are able to compute the complex flow structures that exist in the vicinity of a BMHV. In order to get information about the valve's potential for platelet activation and blood hemolysis, these CFD models must be accompanied by appropriate mathematical models that describe the relation between fluid dynamic variables and the damage to blood corpuscles. This chapter provides an overview on the state of the art in computational flow simulations in BMHV and discusses various approaches taken to integrate blood damage accumulation models into flow simulations.

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Numerical Investigation of the Effect of Blade Geometry on Blood Trauma in a Centrifugal Blood Pump

Cited by 46 publications

References 12 publications

Mechanical Platelet Activation Potential in Abdominal Aortic Aneurysms

Mechanical Platelet Activation Potential in Abdominal Aortic Aneurysms

Towards computational prediction of flow-induced damage of blood cells using a time-accumulated model

Mechanical Valve Fluid Dynamics and Thrombus Initiation

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