Numerical investigation into the influence of the punch shape on the mechanical behavior of pharmaceutical powders during compaction

Krok, Alexander; Peciar, Marián; Fekete, Roman

doi:10.1016/j.partic.2013.12.003

Cited by 36 publications

(27 citation statements)

References 62 publications

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“…Thus, the geometrical parameters of the convex-faced tablets including the diameter (D) and radius of curvature (R) are considered as unknown design variables. Also, it is well reported in the literature, [14], [23] , that the friction between the compaction tools and the powder have a dramatic influence on the performance of the final tablet and for this the friction coefficient ( ) was taken as a design variable in this study to that the higher RDP produce higher shear stress which may lead to cracks inside the tablets. Additionally, the RDP dominates the stresses generated during the ejection phase.…”

Section: Multi-objective Optimisationmentioning

confidence: 99%

“…However, numerical computational modelling tools, such as Finite Element Method (FEM), are very useful techniques providing access to unique results that cannot readily be attained from experimental tests. Recently, modelling techniques were successfully implemented to attain a better insight on the various aspects of the tabletting process such as tablet failure mechanism [6], [7], [8], [9], [10], temperature evolution during the process [8], [11], stress and density distributions within the tablet [12], effect of punch shape [6], [13], and effect of friction [14].…”

Section: Introductionmentioning

confidence: 99%

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Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

2019

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Capping failure, edge chipping, and non-uniform mechanical properties of convexfaced pharmaceutical tablets are common problems in pharma industry. In this paper, Finite Element Modelling (FEM) and Design of Experiment (DoE) techniques are adopted to find the optimal shape of convex-faced (CF) pharmaceutical tablet which has more uniform mechanical properties and less capping and chipping tendency. The effects of the geometrical parameters and friction on the compaction responses of convex-faced pharmaceutical tablets were first identified and analysed. The finite element model of the tabletting process was generated using the implicit code (ABAQUS) and validated against experimental measurements. Response Surface Methodology (RSM) was employed to establish the relationship between the design variables, represented by the geometrical parameters and the friction coefficient, and compaction responses of interest including residual die pressure, the variation of relative density within the tablet, and the relative shear stress of the edge of the tablet. A statistical-based optimisation approach is then employed to undertake shape optimisation of CF tablets. The obtained results demonstrated how the geometrical parameters of CF tablet and the friction coefficient have significant effects on the compaction behaviour and quality of the pharmaceutical tablet.

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Section: Multi-objective Optimisationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

2019

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“…Once the friction coefficient is determined, it can be incorporated in the finite element code for representing the friction during compaction. In this study, no experimental work was performed to determine the friction coefficient and a value of m = 0.1 was used for finite element modelling [16,25].…”

Section: Frictions In Powder Compaction Processmentioning

confidence: 99%

“…A penalty contact option with a friction coefficient value of 0.1 was employed for all contact pairs. This value of friction coefficient was also used by other researchers, for similar investigation [16,25]. All models were subjected to axisymmetric boundary conditions in order to reduce simulation solving times.…”

Section: Finite Element Modellingmentioning

confidence: 99%

“…Overall, the finite element modelling of pharmaceutical powders compaction was used by researchers and engineers to: * Estimate and analyse the stress and density distributions within the tablet where these distributions may influence the mechanical properties, dissolution, drug release, and the potential damage during coating, and transport [11]. * Investigate the effect of punch shape and optimize the compaction tools [15][16]. * Explore the tablet failure mechanism and assess the origin of defect or crack formation [1,12,15,[17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Combination of finite element method and Drucker‐Prager Cap material model for simulation of pharmaceutical tableting process

Baroutaji

Lenihan

Bryan

2017

Materialwissenschaft Werkst

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Density‐dependent Drucker‐Prager Cap (DPC) model is widely used for assessing the compaction behaviour of powders due to its capability of capturing the various phenomena associated with the powder compaction process such as work hardening, nonlinear densification, and frictional and compressible behaviour of the powder. This paper presents a full description of the Drucker‐Prager Cap model for the compaction behaviour of microcrystalline cellulose (MCC) Avicel PH101 pharmaceutical powder. The experimental calibration process of Drucker‐Prager Cap is detailed and all model parameters are calculated as a function of powder relative density. Also, the calibrated parameters are implemented in finite element code to perform a numerical simulation of a typical pharmaceutical tablet. The results showed that the finite element model (FEM) was able to accurately predict the compaction behaviour of the microcrystalline cellulose powder. Furthermore, the finite element predictions of stress and density distributions of the powders during the compaction were used to analyse the failure mechanisms associated with tableting.

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Powder Compaction

Wilson¹,

Roberts²,

Blyth³

2019

Chemical Engineering in the Pharmaceutical Industry

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Numerical investigation into the influence of the punch shape on the mechanical behavior of pharmaceutical powders during compaction

Cited by 36 publications

References 62 publications

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

Compaction analysis and optimisation of convex-faced pharmaceutical tablets using numerical techniques

Combination of finite element method and Drucker‐Prager Cap material model for simulation of pharmaceutical tableting process

Powder Compaction

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