Numerical computation of blood hemodynamic through constricted human left coronary artery: Pulsatile simulations

Pandey, Rupali; Kumar, Manoj; Srivastav, Vivek Kumar

doi:10.1016/j.cmpb.2020.105661

Cited by 22 publications

(6 citation statements)

References 29 publications

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“…N.A-Not available. All images were adapted from [6,11,42,43,47,[57][58][59][60]64,[74][75][76][77][78][79][80][81][82][83][84][85][86][87][88]. N.A-Not available.…”

Section: Blood Flow Studies In Coronary Arteriesmentioning

confidence: 99%

Blood Flow Modeling in Coronary Arteries: A Review

Carvalho

Pinho

Lima

et al. 2021

Fluids

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Atherosclerosis is one of the main causes of cardiovascular events, namely, myocardium infarction and cerebral stroke, responsible for a great number of deaths every year worldwide. This pathology is caused by the progressive accumulation of low-density lipoproteins, cholesterol, and other substances on the arterial wall, narrowing its lumen. To date, many hemodynamic studies have been conducted experimentally and/or numerically; however, this disease is not yet fully understood. For this reason, the research of this pathology is still ongoing, mainly, resorting to computational methods. These have been increasingly used in biomedical research of atherosclerosis because of their high-performance hardware and software. Taking into account the attempts that have been made in computational techniques to simulate realistic conditions of blood flow in both diseased and healthy arteries, the present review aims to give an overview of the most recent numerical studies focused on coronary arteries, by addressing the blood viscosity models, and applied physiological flow conditions. In general, regardless of the boundary conditions, numerical studies have been contributed to a better understanding of the development of this disease, its diagnosis, and its treatment.

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“…N.A-Not available. All images were adapted from [6,11,42,43,47,[57][58][59][60]64,[74][75][76][77][78][79][80][81][82][83][84][85][86][87][88]. N.A-Not available.…”

Section: Blood Flow Studies In Coronary Arteriesmentioning

confidence: 99%

Blood Flow Modeling in Coronary Arteries: A Review

Carvalho

Pinho

Lima

et al. 2021

Fluids

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“…Pressure increase is expected at the pump outlet concomitantly with the increasing pump flow rate and accordingly the pulse values [28]. Furthermore, a gradual increase is observed in pump outlet pressure with the increase in pulse values ranging from a healthy artery with a 0% stenosis rate to an artery with a stenosis rate of 80% [30,31].…”

Section: Figure 5 the Effect Of Pulse Values At Different Stenosis Severities On The Pump Outlet Pressurementioning

confidence: 99%

Experimental Investigation of the Effects of Arterial Geometries in Different Severities of Symmetrical Stenosis on Pressure Drop and Pump Power

Sonmez

Yildirim

Karagöz

et al. 2021

Preprint

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Biomedical studies is among the multidisciplinary studies attracting most interest in recent years. Blood and vessel interactions and consequent hemodynamic effects cause cardiovascular diseases. A testing setup constituted by a peristaltic pump (similar to the heart mechanism) system was installed. The purpose of the experimental study presented is to investigate the effect, pressure drop, peristaltic pump inlet and outlet pressure and most importantly, the amount of power consumed by the peristaltic pump regarding arterial stenosis severity with varying areal stenosis percentages. The tests were performed for the pulse values from 54 to 168 bpm by setting up models with 0%, 60%, 70% and 80% symmetrical stenosis severities. In the study, the pressure difference in the test area increased concomitantly with elevated pulse value and increased stenosis severity. This situation revealed that as the intensity of narrowing increases in vessels, the narrowing space differential pressure increases, and this amount increases even more with increased exertion. The pressure at the peristaltic pump outlet increased concomitantly with elevated pulse value and increased stenosis severity. The peristaltic pump overworked to overcome the increased differential pressure related to the increased pulse value and stenosis severity. This result of the experimental data reveals the necessity to avoid activities requiring high pulse in human arteries similarly with a high percentage of stenosis.

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“…Even though there are several experimental hemodynamic investigations in the article that use in vitro [ 20 – 23 ], in vivo [ 24 – 26 ], or ex vivo [ 27 , 28 ] techniques, there are certain limitations that have been described elsewhere [ 29 – 31 ]. Owing to this, computational methods have recently been the favoured technique of many scholars [ 18 , 32 – 39 ]. These have become an important tool for assessing and forecasting the onset of disease, as well as examining the effectiveness of novel technologies for its treatment.…”

Section: Introductionmentioning

confidence: 99%

A review on non-Newtonian fluid models for multi-layered blood rheology in constricted arteries

Wajihah

Sankar

2023

Arch Appl Mech

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Haemodynamics is a branch of fluid mechanics which investigates the features of blood when it flows not only via blood vessels of smaller/larger diameter, but also under normal as well as abnormal flow states, such as in the presence of stenosis, aneurysm, and thrombosis. This review aims to discuss the rheological properties of blood, geometry of constrictions, dilations and the emergence of single-layered fluid to four-layered fluid models. To discuss further the influence of the aforesaid parameters on the physiologically important flow quantities, the mathematical formulation and solution methodology of the two-layered and four layered arterial blood flow problems studied by the authors (Afiqah and Sankar in ARPN J Eng Appl Sci 15:1129--1143, 2020, Comput Methods Programs Biomed 199:105907, 2021. 10.1016/j.cmpb.2020.105907) are recalled. It should be pointed out that the increasing resistive impedance to flow in three distinct states encompassing healthy, anaemic, and diabetic demonstrates that the greater the restriction in the artery, very few blood is carried to the pathetic organs, leading to subjects’ death. It is also discovered that the pulsatile nature of blood movement produces a dynamic environment that poses a slew of intriguing and unstable fluid mechanical state. It is hoped that the intriguing results gathered from this literature survey and review conducted may help the medical practitioners to forecast blood behaviour mobility in stenotic arteries. Furthermore, the physiological information gathered from the available clinical data from the literature on patients diagnosed with diabetes and anaemia may be beneficial to doctors in deciding the therapeutic procedure for treating some particular cardiovascular disease.

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Numerical computation of blood hemodynamic through constricted human left coronary artery: Pulsatile simulations

Cited by 22 publications

References 29 publications

Blood Flow Modeling in Coronary Arteries: A Review

Blood Flow Modeling in Coronary Arteries: A Review

Experimental Investigation of the Effects of Arterial Geometries in Different Severities of Symmetrical Stenosis on Pressure Drop and Pump Power

A review on non-Newtonian fluid models for multi-layered blood rheology in constricted arteries

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