Numbness and Tingling of Fingers Associated with Parvovirus B19 Infection

Faden, Howard; Gw, Gary; Korman, Michael

doi:10.1093/infdis/161.2.354

Cited by 47 publications

(14 citation statements)

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“…Thus, it may explain the transitory worsening of the MM following a period of neurological improvement observed in case 2. Similarly, Faden et al [5] reported the intermittent recurrence of numbness and tingling over 1 year after acute B19V infection in three patients. This could suggest a specific mechanism for B19V-associated MM and provide a rationale for the treatment of such patients with IVIg, which usually contains high levels of B19 V-specific antibodies.…”

Section: Discussionmentioning

confidence: 78%

“…Faden et al described the occurrence of numbness and tingling of fingers associated with B19V infection in seven patients, but complete neurological, neurophysiological and histological examinations were not performed. However, this pattern is potentially indicative of multifocal neuropathy affecting upper limbs [5]. In one of the patients, the symptoms similarly affected toes on both feet and were combined with motor weakness.…”

Section: Discussionmentioning

confidence: 89%

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Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome

Lenglet¹,

Haroche

Schnuriger

et al. 2011

J Neurol

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To describe the characteristics of peripheral neuropathy related to acute parvovirus B19 (B19V) infection. We reviewed clinical, electrophysiological and histological data of three patients with peripheral neuropathy and positive B19V detection (IgG, IgM and PCR) compatible with acute infection. The neuropathy fulfilled criteria for mononeuropathy multiplex (MM). It could be preceded by or concurrent with a limited purpuric eruption, but systemic manifestations were absent. The first neurological symptoms were always sensory and localized in a hand. Neuropathy was initially limited to a restricted sensory part of a nerve trunk territory. The course was subacute with successive and asymmetric injury of the limb and cranial nerves. Electromyographic study confirmed the diagnosis of MM with multifocal asymmetric sensory and motor axonal loss in two patients, whereas the neuropathy was purely sensory and limited to two nerves in the other patient. Nerve biopsies showed no evidence of necrotizing vasculitis but, in one patient, revealed a lymphocytic perivascular infiltrate evocative of hypersensitivity vasculitis secondary to an infectious agent. Intravenous immunoglobulin (IVIg) was systematically administered. Long-term outcome was good but with incomplete sensory recovery and, for one patient, persistence of a functional disability. B19 V infection should be considered in the etiological assessment of MM, especially in the event of a progressive sensory disorder in the hands and a concomitant history of rash. IVIg may be an effective treatment for this inflammatory disorder.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 89%

Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome

Lenglet¹,

Haroche

Schnuriger

et al. 2011

J Neurol

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“…Faden and colleagues [109] reported seven cases of paraesthesia among nurses, working together in Buffalo, New York, during an outbreak of EI. They suffered from numbness and tingling of fingers.…”

Section: Neuropathymentioning

confidence: 99%

Neurological manifestations of human parvovirus B19 infection

Barah

Vallely

Cleator

et al. 2003

Reviews in Medical Virology

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Since its discovery, human parvovirus B19 has been linked with a broad spectrum of clinical syndromes. An aetiological role for the virus has been confirmed in erythema infectiosum, transient aplastic crisis, persistent infection manifesting as pure red cell aplasia in immunocompromised persons, non-immune hydrops fetalis and arthritis. Less commonly recognised, but receiving increasing attention recently, are the neurological manifestations, a variety of which have been described in patients with either clinically diagnosed or laboratory confirmed B19 infection. The purpose of this review is to summarise present knowledge of B19, its known and potential pathogenic mechanisms and its association with human diseases, particularly those with neurological manifestations. The outcome of the review supports an aetiological role of the virus in neurological disease. However, the pathogenesis remains unknown and elucidating this is a priority.

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“…Neurological involvements have been described as uncommon complications in two cases of fifth disease [5,9], and more recently peripheral neuropathy was described as the only sign of B19 infection [8].…”

Section: Discussionmentioning

confidence: 99%

Different syndromes associated with B19 parvovirus viraemia in paediatric patients: Report of four cases

et al. 1992

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The broad spectrum of clinical manifestations associated with B19 parvovirus often allows the infection to go unrecognized. We tested for the presence of B19 parvovirus and the specific serological response in serum from hospitalized patients submitted for viral investigations without any specific indications for B19 parvovirus. We diagnosed human parvovirus B19 infection in four paediatric patients showing different clinical manifestations. The patients, aged between 5 and 8 years, were admitted to hospital for: (1) petechial rash; (2) mononucleosis-like syndrome; (3) neurological syndrome; and (4) respiratory disease (in an immunodeficient patient).

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Numbness and Tingling of Fingers Associated with Parvovirus B19 Infection

Cited by 47 publications

References 0 publications

Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome

Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome

Neurological manifestations of human parvovirus B19 infection

Different syndromes associated with B19 parvovirus viraemia in paediatric patients: Report of four cases

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