Number, Proliferative Activity, and Expression of Thyroid Hormone Receptors in Dermal Fibroblasts in Mice with Changed Thyroid Status

Гунин, А. Г.; Golubtsova, N. N.; Кравцова, О. А.; Subbotkin, A S; Subbotkina, N O; Filippov, F. N.

doi:10.1007/s10517-019-04443-x

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…1). 7,[37][38][39][40] In addition, there is a plethora of additional effects that are not mediated by direct TRE-TR binding such as TH-mediated miRNA regulation, 41 DNA methylation, 42 metabolic effects of TH, 43 and post-translational modifications of T3 44 to name but a few. 45 Given that T3 shows a considerably higher affinity to cognate nuclear receptors than T4, circulating T4 is thought to largely act after intracellular deiodination into T3 in peripheral organs, including human HFs.…”

Section: Thyroid Hormone ( Th) B I Ologymentioning

confidence: 99%

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

Paus

Ramot

Kirsner

et al. 2020

Experimental Dermatology

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Dermatologists have used natural or synthetic agonists of glucocorticoid, vitamin D or retinoid nuclear hormone receptors, both systemically and topically, for decades in the management of skin diseases. In fact, the introduction of glucocorticoids, calcitriols and retinoids into the clinic each constituted landmark progress in skin therapies, and the range of dermatological indications for each of these distinct classes of chemicals rapidly expanded after they became widely accepted in clinical practice. 1,2 Given the success of these agents, it is surprising that a fourth class of potent nuclear hormone receptor agonists has not been developed as part of the therapeutic arsenal of dermatology: endogenous and synthetic thyroid hormone receptor (TR) ligands. 3 This "Cinderella status" of these peptide hormones among endocrinological dermatotherapy is even more surprising in view of

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Section: Thyroid Hormone ( Th) B I Ologymentioning

confidence: 99%

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

Paus

Ramot

Kirsner

et al. 2020

Experimental Dermatology

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“…It also reduces the uptake of iodine capacity in tumor cells. Scholars found TSHR and NIS become an important cause for PTC in 131-I radiotherapy [37,38]. In human and rabbit thyroid cancer cells, BRAFV600E mutant, a carcinogenic homolog of murine sarcomatous virulent bacterium, could cause activation of BRAF/MEK/ MAPK signaling pathway and expression silencing of thyroid-specific genes including TPO, Tg, TSHR, and NIS.…”

Section: Thyroid-stimulating Hormone Receptor and Sodium/iodide Sympomentioning

confidence: 99%

Research Progress of DNA Methylation in Thyroid Cancer

Zhu¹,

Xie²

2020

DNA Methylation Mechanism

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We have summarized increasing data from all kinds of experiment results of papers in recent years, which are associated with tumor suppressor genes, oncogenes, and thyroid-specific genes and attempt to elucidate the importance of epigenetic modifications and the mechanisms of aberrant DNA methylation in thyroid cancer in this review. The results showed that current articles have revealed the importance of epigenetic modifications and the different types of mechanisms in thyroid cancer. The mechanisms of DNA methylation related to thyroid cancer demonstrate that acquired epigenetic abnormalities together with genetic changes play an important role in alteration of gene expression patterns. Aberrant DNA methylation has been well known in the CpG regions. Among the genes identified, we have shown the status of DNA promoter methylation in papillary, follicular, medullary, and anaplastic thyroid cancer. It suggested that thyroid cancer subtypes present differential promoter methylation signatures, which will encourage potential thyroid cancer detection in its early stages, assessment of prognosis, and targeted cancer treatment.

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Number, Proliferative Activity, and Expression of Thyroid Hormone Receptors in Dermal Fibroblasts in Mice with Changed Thyroid Status

Cited by 2 publications

References 10 publications

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy?

Research Progress of DNA Methylation in Thyroid Cancer

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