Number of amalgam fillings in relation to cardiovascular disease, diabetes, cancer and early death in Swedish women

Abstract

Altogether 1462 women aged 38, 46, 50, 54 and 60 yr were initially examined in 1968-69 in a combined medical and dental population study in Gothenburg, Sweden. Number of tooth surfaces restored with amalgam fillings was assessed. The incidences of myocardial infarction, stroke, diabetes, cancer and overall mortality were determined during a 20-yr follow-up period. Women with few amalgam tooth fillings had increased incidence of myocardial infarction, stroke, diabetes and early death compared with women with a large number of fillings. However, the significant inverse correlations between number of amalgam tooth fillings and the endpoints studied disappeared when number of teeth and socioeconomic group were included in a multivariate analysis. The study thus did not provide any evidence for a correlation between amalgam fillings and cardiovascular disease, diabetes, cancer or early death.

Factors associated with amalgam restorations in Taiwan

“…Finally, Taiwanese population's and dentists' knowledge of and attitudes towards dental amalgam could not be evaluated in this investigation. Results from previous studies did not show significant association between amalgam fillings and cardiovascular disease, diabetes, cancer, early death, impairment of renal or immunological function, [13][14][15] physical or mental health or memory function, 16 or Alzheimer's' disease. 17 However, dental personnel were found to have significantly higher number of central nervous symptoms 18 or less fertile (females).…”

Concentrations of blood, serum and urine components in relation to number of amalgam tooth fillings in Swedish women

“…and 72.7'V;., respectively, relative to baseline participation rates. Infortnation concerning number of tooth sttrfaces filled with /81 1942 1930 1922 1918 1914 1908 -38 46 50 54 60 -372 431 398 180 81 -356 421 390 173 78 -342 378 319 134 48 38 50 58 62 66 72 122 355 332 325 140 49 109 323 305 295 125 41 107 310 261 225 97 24 Total (19,20). The group of wotnen who were 50 yr old in 1980/81 was complemented with 42 women who had moved to the city during the study period and who fulfilled the initial inclusion criteria (21).…”

“…In our previous studies, no correlations have been observed between number of tooth surfaces with amalgam fillings and subjectively experienced symptoms (19), nor between nutnber of amalgatn fillings and the incidence of early death or certain diseases such as diabetes, myocardial infarction and cancer on the population level (20). We now continue our studies on the possible infiuence of amalgam lillings on different functions, and in this paper we focus on biochemical variables reflecting hematological, hepatic, renal and immunological functions.…”

Periodontal disease as a risk factor for acute myocardial infarction. A case-control study in Goans highlighting a review of the literature

“…When the number of decayed teeth, number of missing teeth and number of fi lled teeth were assessed in univariate analysis, we found all these parameters to be significantly higher in the AMI group as compared to the CHD group, as has been shown by many studies. 11,14,18,20,23,24,28,30,49 However, when these parameters were subjected to multivariate logistic regression analysis, only the number of decayed teeth was found to be associated with AMI. Similarly, Touminen et al 40 in their very recent study reported that these associations between missing teeth, decayed teeth, filled teeth and CHD proved to be statistically insignifi cant when considered with other well-established risk factors for CHD.…”