Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: Evidence from an updated meta-analysis

Wang, Bin; Huang, Gang; Wang, Dan; Li, Ai Jun; Xu, Zhipeng; Dong, Ruiqi; Zhang, Deqiang; Zhou, Weiping

doi:10.1016/j.jhep.2010.03.026

Cited by 108 publications

(62 citation statements)

References 48 publications

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“…Finally, gene-gene and gene-environmental factors interactions were not fully addressed in this meta-analysis for the lack of sufficient data. HBV, HCV and several gene polymorphisms, such as P53 codon72, GSTM1 and GSTT1, are associated with liver cancer, and there may be gene-gene or gene-environmental factors interactions (Wang et al, 2010, Ding et al, 2012. However, we could not perform gene-gene and gene-environmental analyses owing to the limited reported information on such associations in the included studies.…”

Section: Discussionmentioning

confidence: 99%

Association Between MDM2 Promoter SNP309 T/G Polymorphism and Liver Cancer Risk - a Meta-analysis

Ma¹,

Huang²,

Han³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Association Between MDM2 Promoter SNP309 T/G Polymorphism and Liver Cancer Risk - a Meta-analysis

Ma¹,

Huang²,

Han³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The reason may be that although some substrates are metabolized by specific GST isozymes, they have overlapping substrate specificities and therefore, combinations of the null genotypes of GSTM1/ GSTT1 could confer an even higher risk [39]. This has also been observed in several tumors, such as colorectal cancer [40], bladder cancer [41] and hepatocellular carcinoma [42], et al…”

Section: Discussionmentioning

confidence: 99%

“…GST genetic polymorphisms have been extensively studied and several meta-analyses combining data from multiple stud-ies have been published to investigate the associations between GST polymorphisms and various cancers [42][43][44][45][46]. Wang et al suggested the null genotypes of GSTM1 and GSTT1 were both associated with increased hepatocellular carcinoma risk [42].…”

Section: Discussionmentioning

confidence: 99%

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Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang

Wang²,

Jx³

et al. 2011

neo

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There were some studies on the associations between Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1 (GSTT1) polymorphisms and cervical cancer (CC) risk, but the results were inconsistent. Thus, a meta-analysis was performed.The electronic databases PubMed, Science Direct, CBM, and CNKI were searched for possible studies. Finally, 16 studies (1,627 cases and 2,161 controls) were included. For the GSTM1 and GSTT1 polymorphisms, the unadjusted odds ratios (OR) and 95% confidence intervals (95% CI) from each study were used to estimate summary OR. Subgroup analyses by ethnicity and histological type of CC were also performed.For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66). Similar association was found in Asians (OR=1.47, 95% CI=1.11-1.94), but not in Caucasians (OR=0.96, 95% CI=0.73-1.27). For the GSTT1 polymorphism, the null genotype of GSTT1 was not statistically significantly associated with CC risk in total population (OR=1.36, 95% CI=0.97-1.90). This result was also found in Asians (OR=1.27, 95% CI=0.87-1.85) and Caucasians (OR=1.09, 95% CI= 0.66-1.79), but not in Latinos (OR=4.58, 95% CI= 2.04-10.28). For the GSTM1/GSTT1 interaction analysis, the dual null genotypes of GSTM1/GSTT1 were significantly associated with increased CC risk in total population (OR=1.77, 95% CI= 1.14-2.75), and all the six studies were from Asia. For subgroup analyses by histological type of CC, the three aspects of the analyses above were all not significantly associated with CC risk in squamous cell carcinoma and adenocarcinoma, respectively.The null genotype of GSTM1 and the dual null genotypes of GSTM1/GSTT1 were risk factors in CC, and the null genotype of GSTT1 was not associated with CC risk.

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“…It is not surprising that TP53 mutations and GSTM1 polymorphisms are the most frequently studied genetic variations. TP53 mutations were found to occur frequently in human cancer about two decades ago (Hussain et al, 2007;Levine and Oren, 2009), and the association between GSTM1 polymorphism and HCC began to attract attention more than 15 years ago (London et al, 1995;White et al, 2008;Wang et al, 2010).…”

Section: Database Contentsmentioning

confidence: 99%

dbHCCvar: A comprehensive database of human genetic variations in hepatocellular carcinoma

Fang

Tang

et al. 2011

Hum. Mutat.

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Hepatocellular carcinoma is a common cancer with a high mortality rate. The complete pathogenesis of hepatocellular carcinoma is not completely understood, and highly efficient therapy is still unavailable. In the past several decades, various genetic variations such as mutations and polymorphisms have been reported to be associated with hepatocellular carcinoma risk, progression, survival, and recurrence. However, to our knowledge, these genetic variations have not been comprehensively and systematically compiled. In this study we constructed dbHCCvar, a free online database of human genetic variations in hepatocellular carcinoma. Eligible publications were collected from PubMed, and detailed information and major research data from each eligible study were then extracted and recorded in our database. As a result, dbHCCvar contains almost all human genetic variations reported to be associated or not associated with hepatocellular carcinoma risk, clinical pathology, drug reaction, survival, or recurrence to date. It is expected that dbHCCvar will function as a useful tool for researchers to facilitate the search and identification of new genetic markers for hepatocellular carcinoma. dbHCCvar is free for all visitors at

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Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: Evidence from an updated meta-analysis

Cited by 108 publications

References 48 publications

Association Between MDM2 Promoter SNP309 T/G Polymorphism and Liver Cancer Risk - a Meta-analysis

Association Between MDM2 Promoter SNP309 T/G Polymorphism and Liver Cancer Risk - a Meta-analysis

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

dbHCCvar: A comprehensive database of human genetic variations in hepatocellular carcinoma

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