Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Wang, D; Wang, B; Jx, Zhai; Dw, Liu; Gg, Sun

doi:10.4149/neo_2011_04_352

Cited by 17 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zhuo et al [63] found that GSTM1 null genotype significantly increased susceptibility to oral cancer among Asians, but not Caucasians. Wang et al [64] reported that the null genotype of GSTM1 was a risk factor in cervical cancer among Asians, but not Caucasians. A recent study by Wang et al [65] showed that an increased hepatocellular carcinoma risk was significantly affected by the null genotype of GSTM1 among Asians.…”

Section: Discussionmentioning

confidence: 99%

Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies

Wei

Zhou

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

BackgroundGlutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis.Methodology/Principal FindingsA comprehensive search was conducted to identify all eligible case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall association was significant (OR = 1.28, 95% CI: 1.11–1.48, P = 0.001). Moreover, subgroup analyses showed GSTM1 null genotype significantly associated with PCa risk among Asians (OR = 1.35, 95% CI: 1.03–1.78, P = 0.03) but not among Caucasians (OR = 1.12, 95% CI: 0.96–1.31, P = 0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa.Conclusions/SignificanceThe present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies

Wei

Zhou

et al. 2012

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In previous studies, GSTM1 deletions have been linked to osteosarcoma incidence [71] and recurrence [72], with a non-statistically significant positive association with soft tissue sarcoma mortality [73]. Other studies of GSTM1 deletions have identified positive associations between the null genotype and a variety of cancers, included oral [45], colorectal [74], cervical [75], and bladder [76].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Stromal Tumors, Somatic Mutations and Candidate Genetic Risk Variants

et al. 2013

View full text Add to dashboard Cite

Gastrointestinal stromal tumors (GISTs) are rare but treatable soft tissue sarcomas. Nearly all GISTs have somatic mutations in either the KIT or PDGFRA gene, but there are no known inherited genetic risk factors. We assessed the relationship between KIT/PDGFRA mutations and select deletions or single nucleotide polymorphisms (SNPs) in 279 participants from a clinical trial of adjuvant imatinib mesylate. Given previous evidence that certain susceptibility loci and carcinogens are associated with characteristic mutations, or “signatures” in other cancers, we hypothesized that the characteristic somatic mutations in the KIT and PDGFRA genes in GIST tumors may similarly be mutational signatures that are causally linked to specific mutagens or susceptibility loci. As previous epidemiologic studies suggest environmental risk factors such as dioxin and radiation exposure may be linked to sarcomas, we chose 208 variants in 39 candidate genes related to DNA repair and dioxin metabolism or response. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between each variant and 7 categories of tumor mutation using logistic regression. We also evaluated gene-level effects using the sequence kernel association test (SKAT). Although none of the association p-values were statistically significant after adjustment for multiple comparisons, SNPs in CYP1B1 were strongly associated with KIT exon 11 codon 557-8 deletions (OR = 1.9, 95% CI: 1.3-2.9 for rs2855658 and OR = 1.8, 95% CI: 1.2-2.7 for rs1056836) and wild type GISTs (OR = 2.7, 95% CI: 1.5-4.8 for rs1800440 and OR = 0.5, 95% CI: 0.3-0.9 for rs1056836). CYP1B1 was also associated with these mutations categories in the SKAT analysis (p = 0.002 and p = 0.003, respectively). Other potential risk variants included GSTM1, RAD23B and ERCC2. This preliminary analysis of inherited genetic risk factors for GIST offers some clues about the disease's genetic origins and provides a starting point for future candidate gene or gene-environment research.

show abstract

“…This may be a result of modified enzymatic activity that predisposes susceptibility to several cancers including carcinoma of skin [5], pancreas [7], liver [13], ovary [14], bladder [15], lung [16], breast [17], head and neck [18], cervix [19], and prostrate [20].This study was designed to investigate the association of GSTM1 and GSTT1 polymorphisms with cervical cancer and to estimate the clinical impact of these polymorphisms in the progression of SCCA.…”

Section: Introductionmentioning

confidence: 99%

The association of GSTM1 and GSTT1 polymorphisms with squamous cell carcinoma of cervix in Pakistan

et al. 2015

View full text Add to dashboard Cite

Gene deletions in GSTM1 and GSTT1 may result in tempering the activation and detoxification of several carcinogens and thereby may increase the risk of cancer pre-disposition. This study aims to investigate the clinical impact of glutathione-S-transferase GSTM1 and GSTT1 polymorphisms on squamous cell carcinoma of cervix (SCCA).The GSTM1 and GSTT1 polymorphisms were analyzed in cervical cancer patients and healthy controls. Touch down multiplex polymerase chain reaction (PCR) strategy was adopted for genotyping of GSTM1 and GSTT1 polymorphisms. The null genotype of GSTM1 exhibited a significantly higher percentage in patients with SCCA (74 %) than in the control group (34.0 %). However, no significant difference was observed in the null genotype of GSTT1 among SCC patients and healthy subjects, respectively. GSTM1 exhibited a significant association with increased risk of squamous cell carcinoma (p < 0.001). The odds ratio for the GSTM1 null genotype was also calculated (odds ratio 3.7484; 95 % confidence interval 1.6562-84834). This suggests that GSTM1 null genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix.

show abstract

Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: A meta-analysis

Cited by 17 publications

References 27 publications

Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies

Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies

Gastrointestinal Stromal Tumors, Somatic Mutations and Candidate Genetic Risk Variants

The association of GSTM1 and GSTT1 polymorphisms with squamous cell carcinoma of cervix in Pakistan

Contact Info

Product

Resources

About