Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies

Abstract

BackgroundGlutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis. Numerous studies have evaluated the association between GSTM1 null/present polymorphism and risk of prostate cancer (PCa). However, the results remain inconsistent. To derive a more precise estimation, we performed a meta-analysis.Methodology/Principal FindingsA comprehensive search was conducted to identify all eligible case-control studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. The overall association was significant (OR = 1.28, 95% CI: 1.11–1.48, P = 0.001). Moreover, subgroup analyses showed GSTM1 null genotype significantly associated with PCa risk among Asians (OR = 1.35, 95% CI: 1.03–1.78, P = 0.03) but not among Caucasians (OR = 1.12, 95% CI: 0.96–1.31, P = 0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa.Conclusions/SignificanceThe present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians.

Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis

“…Thus, the results of mutation are GSTP1 genotypes Ile/Ile, Ile/Val and Val/Val. The exchange of isoleucine and valine in the amino acid chain results in decreased enzymatic activity of protein [58,59].…”

GSTM1 gene polymorphism and the risk of colorectal cancer in a Saudi Arabian population

“…The polymorphism of the GSTM1 gene observed in the human population comprises a hereditary homozygous deletion (null/null), a deletion of a gene fragment, resulting in a deficiency in the protein product, which is related to the total loss of enzymatic activity (Gong et al, 2012). The GSTM1 null genotype seems to be related to a low capacity for detoxification of selected xenobiotics and a reduced capability for controlling oxidative stress, which is equivalent to the damage to the cell caused by free radical activity (Wei et al, 2012). Null genotypes of this mu class gene have been associated with larger numbers of malignant tumors, probably due to an augmented susceptibility to carcinogens and environmental toxins (Procopciuc and Osian, 2014).…”

Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies

“…Thus, these findings support the concept of GSTM1 null genotype as a genetic susceptibility factor of PCa in people who live in Asian countries. Wei et al (2012) evaluated the association between GSTM1 null polymorphism and PCa risk from 36 CaseControl studies,and draw a conclusion that GSTM1 null allele was a low-penetrant risk factor for Pca among East Asians (Chinese,Japanese and Korean). Their article mainly discussed the possible role of ethnic differences in genetic backgrounds,while we want to investigate the situation in the region of Asia, so to explore the assosiation between the gene polymorphism and PCa risk in this region is also significant.…”