Nuestra Experiencia de la Blastomicosis sudamericana en la Argentina

Negroni, P.; Negroni, Ricardo

doi:10.1007/bf02049780

Cited by 13 publications

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“…Results of extensive trials have indicated that adequate responses are obtained in approximately 70.0% of the patients subjected to continuous and prolonged therapy (3,(10)(11)(12). Clinical observations have also revealed that relapses occur in approximately 10% of the cases, presumably because of fungal resistance acquired during the course of inadequate treatment.…”

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confidence: 99%

In vitro susceptibility testing of Paracoccidioides brasiliensis to sulfonamides

Restrepo¹,

Arango²

1980

Antimicrob Agents Chemother

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A total of 60 clinical isolates of Paracoccidioides brasiliensis were tested for susceptibility to sulfadiazine and sulfadimethoxyne by the agar dilution technique. A modification of the Mueller-Hinton medium was devised which gave good growth of the yeast form. The minimum inhibitory concentrations for only 51.6% of the isolates were in the range of the recommended blood serum concentration (50 ,ug/ml (7,14).In spite of these observations, there has been no survey of the in vitro susceptibility of the causative agent, Paracoccidioides brasiliensis, to sulfonamides. Earlier studies either employed complex culture media, which could have antagonized the effect of the drug, or made use of the fungus mycelial phase, which is different from the phase found in tissues, that is, the yeast phase of this dimorphic fungus (5,8,15 This report describes the procedure developed for sulfonamide susceptibility testing and presents data on the susceptibility pattern of 60 different isolates of P. brasiliensis to sulfadiazine and sulfadimethoxyne. MATERIALS AND METHODSFungi. Sixty-five isolates of P. brasiliensis were used in this study. All were from clinical sources (Colombian patients) and represented the original isolate at time of diagnosis, with the exception of three which were obtained during relapses. The stock cultures were kept in Sabouraud glucose agar at approximately 25°C. When needed, they were converted to the yeast phase by subculturing in the special media described below and incubated at 36°C. Identity confirmation was obtained by demonstration of dimorphism and by the characteristic microscopical appearance, multiple budding yeast cells, in cultures incubated at 360C. Culture media. It was necessary to find a medium which would not antagonize sulfonamides and which, at the same time, could promote abundant growth of P. brasiliensis. Earlier attempts to culture the fungus in the conventional Mueller-Hinton medium (BBL Microbiology Systems, Cockeysville, Md.) used for sulfonamide susceptibility testing of bacteria, proved unsuccessful (4, 22). A series of experiments was performed by enriching such a medium with various chemicals known to promote growth in the fungus (1,17

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confidence: 99%

In vitro susceptibility testing of Paracoccidioides brasiliensis to sulfonamides

Restrepo¹,

Arango²

1980

Antimicrob Agents Chemother

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“…A partir das décadas de 1960 e 1970, verificou-se que a infecção se inicia pela inalação dos esporos fúngicos, o que pode ocorrer precocemente, até os 20 anos 23 , produzindo uma lesão inicial nos pulmões [24][25][26] , que geralmente involui ou se converte em um foco latente 27 . A transmissão de Paracoccidioides sp.…”

Section: Apresentação Clínico-radiográfica E Patogêneseunclassified

Etiologia, epidemiologia e manifestações clínicas da paracoccidioidomicose

Júnior¹,

Monti²,

Gaetti-Jardim³

2016

Arch Health Invest

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ResumoAs últimas décadas presenciaram uma modificação significativa na epidemiologia da paracoccidioidomicose. O presente estudo discute retrospectivamente o perfil dos pacientes com essa enfermidade, destacando o papel do cirurgião-dentista no seu diagnóstico, bem como as modificações na distribuição dos casos dessa doença. Observou-se um aumento na notificação de casos dessa micose profunda nas regiões Norte e Centro-Oeste do Brasil, em particular nas frentes agrícolas. Estudos mostraram que outras espécies animais podem atuar como reservatórios dos patógenos do gênero Paracoccidioides, desenvolvendo, em alguns casos, a própria enfermidade. Estudos genéticos também evidenciaram que P. brasiliensis mostrava heterogeneidade significativa e alguns genogrupos passaram a compor nova espécie, P. lutzii, mais frequente na região amazônica. Os autores também discutem o papel da ocupação profissional e fatores hormonais no desenvolvimento de infecções e da enfermidade clinicamente caracterizada devido a Paracoccidioides sp. Além das transformações no conhecimento da doença propriamente dita, o estudo reforçou a importância do cirurgião-dentista no diagnóstico dessa enfermidade. Descritores: Paracoccidioidomicose; Mucosa bucal; Manifestações Bucais; Epidemiologia. AbstractThe last decades have seen profound modifications in the epidemiology of paracoccidioidomycosis. This study aimed to retrospectively discuss the profile of patients presenting this disease, highlighting the role of the dentist in the diagnosis as well the changes in the distribution of cases of this disease. There was an increase in notification of such mycosis in the North and Midwest regions in Brazil, particularly in the agricultural frontiers. Studies have shown that other animal species can act as a pathogen reservoir of genus Paracoccidioides and develop the clinical disease in some circumstances. Genetic studies also showed that P. brasiliensis evidenced significant heterogeneity and some genogroups were reunited into a new species, P. lutzii, more frequent in the Amazon region. The authors also discuss the role of occupation and hormonal factors in the development of these infections and clinically characterized disease due to Paracoccidioides sp. In addition to the changes in the knowledge about this condition, the study reinforced the importance of the dentist in the diagnosis of this disease. Descriptors: Paracoccidioidomycosis; Mouth Mucosa; Oral Manifestations; Epidemiology. ResumenLas últimas décadas han visto un cambio importante en la epidemiología de la paracoccidioidomicosis y este estudio tuvo como objetivo discutir retrospectivamente el perfil de los pacientes con esta dolencia, destacando el papel del odontólogo en el diagnóstico y así como los cambios en la distribución de casos de esta enfermedad. Se observó un aumento en los casos de notificación de esta micosis en las regiones Norte y Centro-Oeste de Brasil, sobre todo en las frentes agrícolas. Los estudios han demostrado que otras especies animales pueden actuar como reservori...

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“…If the patient has good general health, slow progression of localized lesions on the lung, mucous membranes or skin is observed. 15–17 Histopathological characteristics consist of compact epithelioid granulomas with giant cells and few parasites. 15,18 In the anergic pole of chronic paracoccidioidomycosis, pulmonary and mucocutaneous lesions are common and visceral metastatic foci often appear.…”

Section: Introductionmentioning

confidence: 99%

“… 15–17 Histopathological characteristics consist of compact epithelioid granulomas with giant cells and few parasites. 15,18 In the anergic pole of chronic paracoccidioidomycosis, pulmonary and mucocutaneous lesions are common and visceral metastatic foci often appear. Secondary lesions in mucous membranes, ganglia or skin are found in only 10% of cases.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous primary paracoccidioidomycosis

Bustinduy¹,

Guimerá²,

Arevalo³

et al. 2000

Acad Dermatol Venereol

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Paracoccidioidomycosis is a common fungal infection in Latin America. Few cases have been described in non-endemic countries and their diagnosis without the correct suspicion, bearing in mind that the latency period might be up to 60 years, may not be easy. We report the case of a 59-year-old man who worked as a taxi driver for 25 years in Venezuela. Cutaneous paracoccidioidomycosis was diagnosed one year after he returned to Spain. No internal signs or symptoms of the disease were found and cell-mediated immunity showed no depression. Our case suggested us to consider direct cutaneous infection, although respiratory tract is believed to be the most frequent portal of entry for this infection.

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Nuestra Experiencia de la Blastomicosis sudamericana en la Argentina

Cited by 13 publications

References 0 publications

In vitro susceptibility testing of Paracoccidioides brasiliensis to sulfonamides

In vitro susceptibility testing of Paracoccidioides brasiliensis to sulfonamides

Etiologia, epidemiologia e manifestações clínicas da paracoccidioidomicose

Cutaneous primary paracoccidioidomycosis

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