“…There is a rich and diverse pattern of connectivity between AcbSh and VTA (Xia et al, 2011;Brown et al, 2012;Watabe-Uchida et al, 2012;Bocklisch et al, 2013;Lammel et al, 2013;Beier et al, 2015;Nieh et al, 2015;Faget et al, 2016). AcbSh projections to VTA emerge predominantly from D1 expressing SPNs and provide direct inhibitory GABAergic inputs to both VTA dopamine and GABAergic neurons (Bocklisch et al, 2013;O'Connor et al, 2015;Yang et al, 2018). This targeting of different VTA cell types yields diverse effects, including direct and indirect effects of AcbSh inputs on VTA dopamine vs. GABA neurons achieved via different GABA receptors (Edwards et al, 2017) and effects on VTA GABAergic neurons that vary across the medial to lateral VTA (Edwards et al, 2017;Yang et al, 2018).…”