Nucleotide sequence of the complementary DNA for turkey growth hormone

Foster, Douglas N.; Kim, Sung U.; Enyeart, John J.; Foster, Linda K.

doi:10.1016/s0006-291x(05)80880-0

Cited by 15 publications

(5 citation statements)

References 34 publications

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“…1). Use of the sequences of avian (Lamb et al 1988;Chen et al 1988;Foster et al 1991) or turtle (Yasuda et al 1989) GHs as outgroups provides confirmation for most sites in this ancestral sequence. Comparison of the eutherian GH sequences confrms and extends the previous conclusion that GH sequences from representatives of a number of mammalian orders are very similar.…”

Section: Protein Sequencesmentioning

confidence: 82%

Variable evolutionary rates in the molecular evolution of mammalian growth hormones

Wallis

1994

J Mol Evol

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In mammals pituitary growth hormone (GH) shows a slow basal rate of evolution (0.22 +/- 0.03 x 10(-9) substitutions/amino acid site/year) which appears to have increased by at least 25-50-fold on two occasions, during the evolution of primates (to at least 10.8 +/- 1.3 x 10(-9) substitutions/amino acid site/year) and artiodactyl ruminants (to at least 5.6 +/- 1.3 x 10(-9) substitutions/amino acid site/year). That these rate increases are real, and not due to inadvertent comparison of nonorthologous genes, was established by showing that features of the GH gene sequences that are not expressed as mature hormone do not show corresponding changes in evolutionary rate. Thus, analysis of non-synonymous substitutions in the coding sequence for the mature protein confirmed the rate increases seen in the primate and ruminant GHs, but analysis of nonsynonymous substitutions in the signal peptide sequence, synonymous substitutions in the coding sequence for signal peptide or mature protein, and 5' and 3' untranslated sequences showed no statistically significant changes in evolutionary rate. Evidence that the increases in evolutionary rate are probably due to positive selection is provided by the observation that in the cases of both ruminant and primate GHs the periods of rapid evolution were followed by a return to a slow rate similar to the basal rate seen in other mammalian GHs.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Protein Sequencesmentioning

confidence: 82%

Variable evolutionary rates in the molecular evolution of mammalian growth hormones

Wallis

1994

J Mol Evol

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“…The following avian GH coding sequences were included in the analyses: chicken, Gallus gallus (Genbank accession number M35609; Zhvirblis et al. , 1987); turkey, Meleagris gallapavo (M33697; Foster et al , 1991); duck, Anas platyrhynchos (X07079; Chen et al. , 1988); goose, Anser anser (; unpublished data); ostrich, Struthio camelus (; unpublished data); pied flycatcher, Ficedula hypoleuca (Genbank accession DQ218278; Buggiotti & Primmer, unpublished).…”

Section: Methodsmentioning

confidence: 99%

Molecular evolution of the avian growth hormone gene and comparison with its mammalian counterpart

Buggiotti

Primmer

2006

Journal of Evolutionary Biology

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The molecular evolution of all available avian growth hormone (GH) gene sequences was investigated using both maximum‐likelihood and parsimony methods, and the patterns compared to those found in mammals. In contrast to the rapid bursts of evolution observed for mammalian GH, the evolutionary rate of the avian GH mature peptide appears to have been more constant. However several positively selected sites were identified at functionally important positions in the avian signal peptide by the site‐specific likelihood method. This implies that sequence variation in the avian GH signal peptide may be adaptive, although more conservative parsimony methods failed to confirm this. Nevertheless, the differing patterns of avian and mammalian GH signal peptide molecular evolution are consistent with the apparently differing roles of GH in controlling growth in these taxonomic groups and support the hypothesis that signal peptide sequence variation may in fact be the basis for increased functional complexity.

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“…For a review of the genes that had been cloned and sequenced for poultry through about 1988, see Bui field, 1990. Numerous other structural genes, including those controlling the pituitary hormones, have been sequenced and cloned since that time (Souza et al, 1984;Chen, et al, 1988;Foster and Foster, 1991;Foster et al 1990. These accomplishments have given scientists encouragement that the understanding of the structure and location of such genes can in some way be directly or indirectly used in animal improvement schemes.…”

Section: Discussionmentioning

confidence: 99%