Nucleotide coordination with 14 lanthanides studied by isothermal titration calorimetry

Zhang, Zijie; Morishita, Kiyoshi; Lin, Wei Ting David; Huang, Po‐Jung Jimmy; Liu, Juewen

doi:10.1016/j.cclet.2017.06.014

Cited by 29 publications

(37 citation statements)

References 57 publications

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“…All samples spontaneously formed particles as judged from increased turbidity (Figure 1B), and the Tb 3+ /GMP sample also showed strong green luminescence, also indicating the coordination reaction. 28 Previous work showed that both the nucleobase and the phosphate of these nucleotides are required for forming such CPs, 28,40,41 and a proposed structure of Ln 3+ /GMP is also shown in Figure 1A.…”

Section: Resultsmentioning

confidence: 90%

“…28,39 We have recently performed a systematic titration of lanthanides to nucleotides and found a continuous thermodynamic trend. 40 We hypothesize that it might be possible to continuously tune the interaction strength between DNA and lanthanide containing CPs by varying the lanthanide and/or nucleotides. In this work, we wanted to achieve two goals: (1) a careful study of DNA adsorption by such CPs in terms of material composition and interaction forces; and (2) tuning DNA adsorption affinity.…”

Section: Introductionmentioning

confidence: 99%

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Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

Zhang

Liu

et al. 2018

ACS Omega

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Metal–organic coordination polymers (CPs) have attracted great research interest because they are easy to prepare, porous, flexible in composition, and designable in structure. Their applications in biosensor development, drug delivery, and catalysis have been explored. Lanthanides and nucleotides can form interesting CPs, although most previous works have focused on a single type of metal ligand. In this work, we explored mixed nucleotides and studied their DNA adsorption properties using fluorescently labeled oligonucleotides. Adenosine monophosphate (AMP) and guanosine monophosphate (GMP) formed negatively charged CP nanoparticles with most lanthanides, and thus a salt was required to adsorb negatively charged DNA. DNA adsorption was faster and reached a higher capacity with lighter lanthanides. Desorption of pre-adsorbed DNA by inorganic phosphates, urea, proteins, surfactants, and competing DNA was successively carried out. The results suggested the importance of the DNA phosphate backbone, although hydrogen bonding and DNA bases also contributed to adsorption. The AMP CPs adsorbed DNA more strongly than the GMP ones, and using mixtures of AMP and GMP, continuous tuning of DNA adsorption affinity was achieved. Such CPs were also used as a sensor for DNA detection based on the different affinities of single- and double-stranded DNA, and a detection limit of 0.9 nM target DNA was achieved. Instead of tuning DNA adsorption by varying the length and sequence of DNA, the composition of CPs can also be controlled to achieve this goal.

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Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

Zhang

Liu

et al. 2018

ACS Omega

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“…We did as ystematic isothermal titration calorimetry (ITC) study to follow the heatp rofile from adding trivalentl anthanide ions to GMP ( Figure 6) and other nucleotides. [34] All the ions have as imilarb inding affinity,b ut the heat profile gradually changed from releasing heat to absorbing heat, suggesting the contribution of entropyi ncreased with increasing atomic number of lanthanide. Another interesting observation was the difference between pyrimidine and purinem onophosphates with respect to lanthanide binding.…”

Section: Lanthanidesmentioning

confidence: 99%

“…Actually,b inding to phosphate is even more important since none of the nucleobases alone can form CPs with lanthanides. [34] An early study by Nishiyabua nd co-workers explored the binding betweenl anthanidesa nd nucleotide monophosphates. [27] The general reaction scheme is shown in Figure 5A.T hey observed CP nanoparticles between 30-200 nm in diameter from SEM ( Figure 5B)a nd TEM ( Figure 5C).…”

Section: Lanthanidesmentioning

confidence: 99%

“…Arepresentativeexample is the binding of lanthanides by AMP or GMP,w here the N7 and phosphate are both involved. [34,35] The binding of ATPb yM g 2 + is also believed to be via both phosphate and the adenine base ( Figure 2D,E ). [36] Detailed review of metal coordination by nucleotidesi sa vailable elsewhere, [13,14,16,17,[36][37][38] and we only give ab rief summary here as ab asis for subsequentd iscussion.…”

Section: Introductionmentioning

confidence: 99%

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Self‐Assembly of Nucleobase, Nucleoside and Nucleotide Coordination Polymers: From Synthesis to Applications

Lopez

Liu

2017

ChemNanoMat

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With multiple metal binding sites, nucleobases, nucleosides, and nucleotides form various coordination polymers (CPs) with metal ions. These self-assembled materials are very interesting for their simplicity to prepare, highly tunable structure and properties, and excellent biocompatibility.P olymerization is achieved under ambient conditions without the need of free radical initiators or UV light. Different nucleobases have different metal-binding preferences, but in general most of their coordinations ites prefer borderline or soft metals, while the phosphate groups in the nucleotides prefer hard Lewis acids. In this Focus Review,r ecent developments in this fielda re summarized startingf rom the synthesis and characterization of these CPs. Various metal ions includingg old, silver,l anthanides, zinc, copper, and iron are individually reviewed, and each metal brings its own property into the CP materials.While mostoft hese materials are non-crystalline nanoparticles, under certainc onditions crystalline metal-organic frameworks (MOFs) andh ydrogels can also be prepared. The applicationso fs uch CPs are then described including enzyme entrapment,d rug loading and delivery, biosensor development, catalysis, coating of nanoparticles, and luminescence. Finally,f uture research opportunities of this field are discussed.

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Tuning the Electronic Configuration of Oxygen Atom in Engineering Non‐Self‐Limited Nanozyme for Portable Immunosensor

Qileng,

Liu,

Liang

et al. 2023

Adv Funct Materials

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Nanozymes are conceived to replace natural enzymes to avoid expensive processing techniques and fragile reservation conditions. Unfortunately, the self‐limited reaction has run counter to the desire for sustainable catalysis as natural enzymes. Herein, the universal mechanism to overcome the self‐limitation of nanozymes caused by the absorption of ions on the active sites is explored. Therefore, the dual noble metals (Au/Pt) are introduced as the center to synthesize two kinds of nanozymes with different types of central metal elements (Cu and Ce) and also compounds (metal‐organic framework and metallic oxide), showing a similar bond between a central metal and oxygen atom. The morphology characterization and density functional theory calculations demonstrate that the improvement in the electronic environment of neighboring oxygen atoms by inducing the charge redistribution via the bond between noble metals and compounds is crucial for enhancing catalytic activity and avoiding the adsorption of the nontarget substrate. This work not only experimentally proves that the adjustment on the electronic environment of adjacent atoms in the catalytic center is a feasible and universal approach to overcome the self‐limited reaction, but also achieves the application of self‐powered and portable immunosensor to broaden nanozymes in sensitive detection of illegal addition in food.

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Nucleotide coordination with 14 lanthanides studied by isothermal titration calorimetry

Abstract: ITC reveals the increasingly importance of entropy for heavier lanthanides binding to nucleotides. The phosphate group forming chelating effect with purine bases but not with pyrimidines.

Cited by 29 publications

References 57 publications

Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

Continuously Tunable Nucleotide/Lanthanide Coordination Nanoparticles for DNA Adsorption and Sensing

Self‐Assembly of Nucleobase, Nucleoside and Nucleotide Coordination Polymers: From Synthesis to Applications

Tuning the Electronic Configuration of Oxygen Atom in Engineering Non‐Self‐Limited Nanozyme for Portable Immunosensor

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