Nucleotide and DNA coordinated lanthanides: From fundamentals to applications

He, Yanping; Lopez, Anand; Zhang, Zijie; Chen, Da; Yang, Ronghua; Liu, Juewen

doi:10.1016/j.ccr.2019.02.020

Cited by 54 publications

(34 citation statements)

References 113 publications

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“…28,29 CPs have attracted attention in recent years and are competitive candidates for enzyme entrapment because metal coordination and enzyme encapsulation take place under mild conditions without using toxic radicals or organic solvents. 30 Various biomolecules, including nucleotides, amino acids, peptides and proteins, have multiple metal binding sites and can be used as ligands to construct CPs. 31 Because they have both nucleobases and phosphate groups, nucleotides are among the most robust ligands with excellent metal coordination properties.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of lipases by nucleotide/metal ion coordination polymers: enzymatic properties and their applications in glycerolysis and esterification studies

Chen

Song

et al. 2022

J Sci Food Agric

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BACKGROUND In the present study, lipases of TLL (lipase from Thermomyces lanuginosus), AOL (lipase from Aspergillus oryzae), RML (lipase from Rhizomucor miehei), BCL (lipase from Burkholderia cepacia), CALA (Candida antarctica lipase A) and LU (Lecitase® Ultra) were encapsulated into nucleotide‐hybrid metal coordination polymers (CPs). Enzyme concentration was optimized for encapsulation and the enzymatic properties of the obtained lipases were investigated. In addition, their performance in glycerolysis and esterification was evaluated, and glycerolysis conditions (water content, temperature and time) were optimized. RESULTS Hydrolysis activity over 10 000 U g−1 and activity recovery over 90% were observed from AOL@GMP/Tb, TLL@GMP/Tb and RML@GMP/Tb. GMP/Tb encapsulation (of AOL, TLL, RML and LU) improved their thermostability when incubated in air. The encapsulated lipases exhibited moderate [triacylglycerols (TAG) conversion 30–50%] and considerable glycerolysis activity (TAG conversion over 60%). TAG conversions from 69.37% to 82.35% and diacylglycerols (DAG) contents from 58.62% to 64.88% were obtained from CALA@GMP/metal samples (except for CALA@GMP/Cu). Interestingly, none of the encapsulated lipases initiated the esterification reaction. AOL@GMP/Tb, TLL@GMP/Tb, RML@GMP/Tb and CALA@GMP/Tb showed good reusability in glycerolysis, with 88.80%, 94.67%, 89.85% and 78.16% of their initial glycerolysis activity, respectively, remaining after five cycles of reuse. The relationships between temperature and TAG conversion were LnV0 = 6.5364–3.7943/T and LnV0 = 13.8820–6.4684/T for AOL@GMP/Tb and CALA@GMP/Tb, respectively; in addition, their activation energies were 31.55 and 53.78 kJ mol−1, respectively. CONCLUSION Most of the present encapsulated lipases exhibited moderate and considerable glycerolysis activity. In addition, AOL@GMP/Tb, TLL@GMP/Tb, RML@GMP/Tb and CALA@GMP/Tb exhibited good reusability in glycerolysis reactions and potential in practical applications. © 2022 Society of Chemical Industry.

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Section: Introductionmentioning

confidence: 99%

Encapsulation of lipases by nucleotide/metal ion coordination polymers: enzymatic properties and their applications in glycerolysis and esterification studies

Chen

Song

et al. 2022

J Sci Food Agric

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“…Nucleotide‐hybrid metal CPs are porous and they can encapsulate guest molecules. In addition, metal coordination and encapsulation take place in mild conditions, without using toxic radicals and organic solvents, rendering it attractive for enzyme entrapment 26 . Enzymes encapsulation and immobilization into and onto the CPs were studied and improvements in enzymatic features were reported in some recent literatures.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of CALB by nucleotide/metal ions coordination nanoparticles: highly selective catalysis of esterification while poor performance in glycerolysis reaction

Chen

Zhong

2021

J Sci Food Agric

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BACKGROUND Enzymatic esterification is attracting for particular high‐acid oil deacidification. In this study, Candida antarctica lipase B (CALB) was encapsulated into a series of nucleotide‐hybrid metal coordination polymers (CPs), which were constructed by guanosine 5′‐monophosphate (GMP) and various metals. RESULTS We here found that, most of the present CPs encapsulated CALB (CALB@CPs) samples were highly selective for esterification while poor in glycerolysis reaction. They exhibited quite poor performance in glycerolysis, with triacylglycerols (TAGs) conversion lower than 5%, despite this considerable enzymatic hydrolysis activities were observed. However, they (most of them) showed good performance in esterification of fatty acids and glycerol for TAG synthesis. In addition, the GMP/Tb (CPs constructed by GMP and Tb3+) encapsulated CALB (CALB@GMP/Tb) transformed over 98% of oleic acid into glycerides in the high‐acid oil deacidification process, and TAG content from 87 to 89% was obtained. Moreover, the CALB@GMP/Tb showed good reusability in the esterification system. CONCLUSION The present CALB@CPs samples are selective for esterification and suitable for high‐acid oils deacidification. This work provides a new system for enzymatic selectivity improvement study. © 2021 Society of Chemical Industry.

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“…Several lanthanide cations, such as Sm 3+ , Eu 3+ and Tb 3+ have luminescence properties which have been exploited 59 for DNA recognition, though no structural studies are currently available, and the binding modes are beyond the scope of this review. The ruthenium polypyridyl complexes typified by the 'light-switch' complex [Ru(bpy)2(dppz)] 2+ are better understood (dppz=dipyridophenazine).…”

Section: Figure 12 Perpendicular Intercalation A) the Intercalation mentioning

confidence: 99%

Interactions Between Metal Ions and DNA

Cardin

2019

The Periodic Table II

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84 years elapsed between the announcements of the Periodic Table and that of the DNA double helix in 1953, and the two have been combined in many ways since then. In this chapter an outline of the fundamentals of DNA structure leads into a range of examples showing how the natural magnesium and potassium ions found in nature can be substituted in a diversity of applications. The dynamic structures found in nature have been studied in the more controlled, but artificial environment of the DNA crystal using examples from sodium to platinum, and also in a range of DNA-binding metal complexes. While nmr is an essential technique for studying nucleic acid structure and conformation, most of our knowledge of metal ion binding has come from X-ray crystallography. These days the structures studied, and therefore also the diversity of metal binding, go beyond the double helix to triplexes, hairpin loops, junctions and quadruplexes, and the chapter describes briefly how these pieces fit into the DNA jigsaw. In a final section, the roles of metal cations in the crystallisation of new DNA structures are discussed, along with an introduction to the versatility of the Periodic Table of absorption edges for nucleic acid structure determination.

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Nucleotide and DNA coordinated lanthanides: From fundamentals to applications

Cited by 54 publications

References 113 publications

Encapsulation of lipases by nucleotide/metal ion coordination polymers: enzymatic properties and their applications in glycerolysis and esterification studies

Encapsulation of lipases by nucleotide/metal ion coordination polymers: enzymatic properties and their applications in glycerolysis and esterification studies

Encapsulation of CALB by nucleotide/metal ions coordination nanoparticles: highly selective catalysis of esterification while poor performance in glycerolysis reaction

Interactions Between Metal Ions and DNA

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