Nucleoside‐Based Phospholipids and Their Liposomes Formed in Water

Abstract

Phospholipids and liposomes have been the subjects of considerable attention because of their importance in biological systems. We have efficiently synthesized novel nucleoside-based phospholipids in six-step sequences starting from their corresponding nucleosides. These nucleoside-based phospholipids self-assemble into liposome-like structures in aqueous solutions. We have analyzed the structures of these liposomes by dynamic light scattering, transmission electron microscopy, and confocal microscopy.

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery

“…Before being analyzed by TEM, the particles were disposed by the negative-staining technique (2% potassium phosphotungstate at pH 6.8–7.4). 45 The resulting micrographs are displayed in Fig. 3b .…”

Nucleosides with 5′‐Fixed Lipid Groups – Synthesis and Anchoring in Lipid Membranes

“…The residue was treated with toluene and evaporated, and the cycle was repeated three times. The crude material was purified by silica gel chromatography (MeOH/DCM, 1:14 + Et 3 …”