Nucleolar and AgNOR-analysis of Prostatic Intraepithelial Neoplasia (PIN), Atypical Adenomatous Hyperplasia (AAH) and Prostatic Carcinoma

Helpap, B.; Riede, C.

doi:10.1016/s0344-0338(11)80723-5

Cited by 30 publications

(26 citation statements)

References 50 publications

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“…Prostate carcinoma cases showed a significant increase in AgNOR counts compared with benign diseases (p ! 0.001), matching the results of other studies [12][13][14] . The difference between HGPIN and localized prostate carcinoma was not significant in our study (p !…”

Section: Discussionsupporting

confidence: 90%

Role of AgNOR Count and Its Correlation with Serum PSA Levels in Prostatic Lesions

Goel

Garg²

2007

Urol Int

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Section: Discussionsupporting

confidence: 90%

Role of AgNOR Count and Its Correlation with Serum PSA Levels in Prostatic Lesions

Goel

Garg²

2007

Urol Int

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“…Significant increases in N O R counts of PIN as com pared to BPH with or without prostatitis or AAH were quite similar to those observed in previous reports [7,8,17], whereas Chevillc et al [18] failed to observe any dif ference between NORs counted in BPH and PIN.…”

Section: Discussionsupporting

confidence: 89%

“…The mean N O R count of AAH was slightly higher than in BPH with prostatitis, but the difference was statistical ly not significant, being consistent with earlier reports [7,17] where a mild increase in the N O R count was observed in A AH .…”

Section: Discussionsupporting

confidence: 89%

Argyrophilic Nucleolar Organizer Regions in Atypical Adenomatous Hyperplasias, Prostatic Intraepithelial Neoplasias and Prostatic Neoplasms

Mukherjee¹,

Misra²,

Gupta³

et al. 1997

Urol Int

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Sections from 104 cases of benign, preneoplastic and neoplastic lesions of the prostate were studied for argyrophilic nucleolar organizer regions (AgNORs). The mean NOR counts in normal controls (2.87) and benign prostatic hyperplasia with or without chronic prostatitis (4.90 and 3.84 NORs/nucleus, respectively) were found to be significantly less (p < 0.001) than that in prostatic intraepithelial neoplasia (PIN) and adenocarcinoma of the prostate (5.65 and 5.78 NORs/nucleus, respectively). The mean AgNOR count of a section with atypical adenomatous hyperplasia was significantly lower than that in PIN. No statistically significant difference was observed between AgNOR counts of high-grade PIN and well-differentiated adenocarcinoma (WDAC; 5.67 vs. 5.78 NORs/nucleus, respectively), however the difference between low-grade PIN and WDAC was statistically significant (5.46 vs. 5.78 NORs/ nucleus, p < 0.005). The increase in NOR counts occurred concomitantly with the decrease in the degree of differentiation of adenocarcinoma. Thus, NOR was found to be a good adjuvant to the existing diagnostic parameters to pick up more cases at the stage of PIN when prognosis is better.

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“…The aetiology and pathogenesis of the disease remain uncertain. The interaction between steroids (8,10,17), peptide hormones (e.g. prolactin), the effect of some growth factors (4,16,18), and changed sensitivity of prostatic tissue play important roles (13,19).…”

Section: Introductionmentioning

confidence: 99%

“…Hyperplasia is thought to be related to acinar basal cells, while neoplasia is held to be related to ductal basal cells (12). Their sensitivity to factors influencing hyperplastic or neoplastic growth is unequal (8,9).…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric study of the canine prostate during ageing and in cases of benign prostate hyperplasia

Juodžiukynienė

Aniulienė

2016

Journal of Veterinary Research

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Introduction: The aim of the study was to examine the percentage volume of epithelium, acini, and interstitial collagen in the nonhyperplastic canine prostate and in cases of epithelial and epithelial cystic hyperplasia. Material and Methods: A histomorphometric study of 39 prostates was performed using computer image analysis. Results: The highest percentage volume of epithelium was found in cases of epithelial hyperplasia (47.8 %) and epithelial cystic hyperplasia was the correlate for acini (48.97 %). Epithelium decreased with dogs' age (P < 0.01), whereas acini increased (P < 0.01). Interstitial collagen varied only insignificantly across age groups, but collagen was higher (12.1 %) in the nonhyperplastic prostates. With age cystic formation progressed in the canine prostate, the percentage volume of epithelium decreased and that of acini increased, but this same parameter in prostatic collagen did not change distinctly. The epithelium percentage volume increased in cases of epithelial hyperplasia but the cystic variant caused an increase in acinar volume. Conclusion: As dogs age, cystic formation progresses in the prostate, therefore the volume of epithelium decreases and that of acini increases. The volume of prostatic collagen did not change distinctly with age, and was higher in normal prostates than in both epithelial and epithelial cystic hyperplastic glands.

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Nucleolar and AgNOR-analysis of Prostatic Intraepithelial Neoplasia (PIN), Atypical Adenomatous Hyperplasia (AAH) and Prostatic Carcinoma

Cited by 30 publications

References 50 publications

Role of AgNOR Count and Its Correlation with Serum PSA Levels in Prostatic Lesions

Role of AgNOR Count and Its Correlation with Serum PSA Levels in Prostatic Lesions

Argyrophilic Nucleolar Organizer Regions in Atypical Adenomatous Hyperplasias, Prostatic Intraepithelial Neoplasias and Prostatic Neoplasms

Histomorphometric study of the canine prostate during ageing and in cases of benign prostate hyperplasia

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