Nucleic acid therapy for lifespan prolongation: Present and future

Lai, Wing‐Fu

doi:10.1007/s12038-011-9096-z

Cited by 22 publications

(7 citation statements)

References 52 publications

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“…To enhance the efficiency in loading nucleic acids, graphene-based carriers are often functionalized with polycations. One of the widely used polycations is PEI [90] , which on one hand can interact with negatively charged nucleic acids [91] , [92] , [93] , [94] , [95] and on the other hand can provide active groups for further functionalization to enhance the transfection efficiency and the tissue targeting capacity. This is demonstrated by an earlier study [96] , which has functionalized GO with PEI as a gene carrier and has found that the PEI moieties enable the carrier to complex with nucleic acids and to promote the adhesion of the complex to the plasma membrane for enhanced cellular uptake [96] .…”

Section: Design Of Graphene-based Materials For Bioactive Agent Deliverymentioning

confidence: 99%

Use of graphene-based materials as carriers of bioactive agents

Lai

Wong

2021

Asian Journal of Pharmaceutical Sciences

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Graphene possesses a large specific surface area, a high Young's modulus, high fracture strength, high electrical conductivity, and excellent optical performance. It has been widely studied for biomedical use since its first appearance in the literature. This article offers an overview of the latest advances in the design of graphene-based materials for delivery of bioactive agents. To enhance the translation of these carriers into practical use, the toxicity involved is needed to be examined in future research in more detail. In addition, guidelines for standardizing experimental conditions during the evaluation of the performance of graphene-based materials are required to be established so that candidates showing higher practical potential can be more effectively identified for further development. This can streamline the optimization and use of graphene-based materials in delivery applications.

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Section: Design Of Graphene-based Materials For Bioactive Agent Deliverymentioning

confidence: 99%

Use of graphene-based materials as carriers of bioactive agents

Lai

Wong

2021

Asian Journal of Pharmaceutical Sciences

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“…DNA nanotechnology involves the development of programmable nanoscale building materials 63–67 . These materials are easy to assemble to readily attain the desired shapes 68–71 .…”

Section: Summary and Outlooksmentioning

confidence: 99%

Development and functionalization of DNA nanostructures for biomedical applications

Zou

Neelakantan

Zhang

2021

J Chinese Chemical Soc

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Nanomaterials are excellent drug delivery systems, yet, they must be functionalized in a manner compatible with the biological environment. Regarding delivery of the payloads, it is critical to monitor the nanocarrier's biocompatibility and the ability to control its drug encapsulation and release, as well as targeting. The current challenges include avoiding negative host immune responses, optimizing stability in biological environments, and achieving precise interactions with the targets. Contemporary advances in structural DNA nanotechnology, DNA origami, and supramolecular DNA assembly make it possible to produce complex multi‐functional DNA nanostructures, wherein precise control of the size, geometry, and appearance of the ligands is feasible. DNA nanostructures offer ease of synthesis and conjugation of functional moieties to target the release of cargo or to analyze important biomarkers for diagnostics. Furthermore, the biocompatibility, programmability, responsiveness to biomolecules, cell‐surfaces, and organisms make such DNA nanomaterials highly suitable for potential translational applications. This overview summarizes the recent developments in functionalizing, stabilizing, and applying DNA nanostructures for potential biomedical applications.

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“…Contrary to the delivery of chemical drugs, in which the intervention will still be therapeutic even if the carrier fails to be internalized into cells but simply releases the payload outside, gene therapy is possible only when cellular internalization of the delivered gene is successful. 58 – 60 As far as cellular uptake is concerned, the size and zeta potential of the nanoparticles are two important determining factors. A small size can be achieved by surface passivation or functionalization to enhance the colloidal stability of UCNPs.…”

Section: Molecular Design Of Ucnps As Gene Carriersmentioning

confidence: 99%