Nucleic acid-specific suppressor T cells.

Borel, Yves; Young, Michael C.

doi:10.1073/pnas.77.3.1593

Cited by 13 publications

(9 citation statements)

References 18 publications

(8 reference statements)

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“…More recently, suppressor T cells specific for nucleosides have been elicited in vivo [8,40]. The latter finding might be of importance not only for therapy, but also for exploring the role of suppressor T cells specific to nucleic acid in the pathogenesis of systemic lupus erythematosus.…”

Section: Tolerance To Nucleic Acid Antigens To Treat Murine Lupusmentioning

confidence: 99%

“…The dichotomy between these two phenomena is illustrated by several observations dealing with both the cellular mechanism and the specificity of unresponsiveness [6]. For example, whereas guanosine linked to IgG induces guanosine specific tolerance only, guanosine linked to cells suppresses antibodies not only to guanosine, but also to cytosine and adenosine [8,27]. Suppression affects both the expression of cellular (T) and humoral (B) immunity and is mediated by specific suppressor T cells [15,33].…”

Section: Tolerance To Nucleic Acid Antigens To Treat Murine Lupusmentioning

confidence: 99%

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From nonspecific to specific immunosuppression facts and speculation

Borel

1984

Springer Semin Immunopathol

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Section: Tolerance To Nucleic Acid Antigens To Treat Murine Lupusmentioning

confidence: 99%

Section: Tolerance To Nucleic Acid Antigens To Treat Murine Lupusmentioning

confidence: 99%

From nonspecific to specific immunosuppression facts and speculation

Borel

1984

Springer Semin Immunopathol

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“…It is well known that immunological unresponsive ness is induced by the transfer of syngeneic lymphoid cells modified chemically with haptens [1], nucleic ac ids [2], and proteins [3]. With these antigens, suppres sor T cells [4], as well as killer cells [5], are generated in mice.…”

Section: Introductionmentioning

confidence: 99%

Suppression of IgE Antibody Response by Preadministration of Antigen-Pulsed Spleen Cells

Kojima¹,

Mabuchi²,

Yokomuro³

et al. 1984

Int Arch Allergy Immunol

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Intravenous administration of syngeneic spleen cells (SPC), briefly pulsed with antigen in vitro, resulted in a profound state of IgE antibody unresponsiveness. One of the mechanisms of this unresponsiveness is responsible for an immediate tolerance which is induced without any suppressor cells. Characteristics of this immediate tolerance were investigated. Administration of antigen-pulsed spleen cells 4 h before the immunization, suppressed the production of IgE antibody triggered by the subsequent immunization. Pretreatment with cyclophosphamide had no effect on this rapid suppression, and this suppressive state could not be transferred to normal syngeneic recipients by the injection of spleen cells from the tolerant mice used in our experiment. These observations suggest that suppressor cells do not play an important role in immediate tolerance. The extent of this immediate tolerance induced by the injection of antigen-pulsed SPC depends on the number of antigen-pulsed SPC and the dose of antigen to which SPC had been exposed. Injection route of antigen-pulsed SPC has a great influence on the induction of immediate tolerance. The order of suppressive extent is intravenous, > intraperitoneal > subcutaneous. This suppression is specific to the antigen pulsed to SPC. Carrier-specific T cells are the major target of suppression in immediate tolerance. Antigen-pulsed T cells induce immediate tolerance most effectively in the subpopulations of SPC.

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“…It is well known that the immunologic unrespon siveness is induced by the transfer of syngeneic lym phoid cells modified chemically with haptens [1][2][3], nucleic acids [4] and proteins [5], With these antigens, suppressor T cells [1][2][3][4][5], as well as killer cells [6], are produced in mice. However, the chemical modifica tion of lymphoid cells by these substances would not normally occur in vivo except in special circum stances when animals are exposed to chemicals such as DNFB ( I-fiuoro-2,4 dinitrobenzene) or TNBS (2,4,6-trinitrobenzene sulfonic acid), and so on.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Immune Response by Preadministration of Cells Briefly Pulsed with Antigen in vitro

Yokomuro

Mabuchi

Saizawa

et al. 1982

Int Arch Allergy Immunol

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The intravenous administration of syngeneic spleen cells (SPCs) briefly pulsed with antigen in vitro, results in a profound state of IgE antibody unresponsiveness. In Balb/c mice, the primary response of anti-DNP, anti-beef insulin and anti-ovalbumin IgE antibody is completely suppressed by the administration of antigen-pulsed spleen cells, 1 × 10⁷, 5 × 10⁷ and 1 × 10⁸, respectively. This suppression is antigen specific and effects both primary and secondary immune responses. Furthermore, the immune response to dinitrophenylated Keyhole limpet hemocyanin (DNP-KLH) is most extensively suppressed by DNP-KLH pulsed SPCs, intermediately suppressed by KLH-pulsed SPCs and minimally suppressed by dinitrophenylated mouse gamma globulin or dinitrophenylated mouse serum albumin pulsed SPCs. Suppressing directly cells specific for hapten and carrier, hapten carrier protein pulsed SPCs would caused the additive suppressive effect. The suppression is induced strongly by the intravenous administration of antigen pulsed spleen cells, slightly by the subcutaneous administration and is not induced by the intravenous administration of antigen solution in phosphate buffer saline. This suppression may be mediated by either of two different mechanisms: one of them is responsible for the immediate tolerance which is induced without any suppressor cells 1 day after the administration of antigen pulsed SPCs, and the other is responsible for the suppression transferred by suppressor cells or factors to normal mice 7 days after the administration of antigen pulsed SPCs. This method in which IgE antibody response is suppressed by the administration of cells briefly pulsed in vitro with antigen, provides a powerful tool to analyze the first step of antigen specific suppression developed in vivo by conventional antigens.

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Nucleic acid-specific suppressor T cells.

Cited by 13 publications

References 18 publications

From nonspecific to specific immunosuppression facts and speculation

From nonspecific to specific immunosuppression facts and speculation

Suppression of IgE Antibody Response by Preadministration of Antigen-Pulsed Spleen Cells

Regulation of Immune Response by Preadministration of Cells Briefly Pulsed with Antigen in vitro

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