From nonspecific to specific immunosuppression facts and speculation

Borel, Yves

doi:10.1007/bf01891776

Cited by 2 publications

(1 citation statement)

References 38 publications

(15 reference statements)

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“…NO. 4,1992 IMMUNOSUPPRESSIVE THERAPY AND IMMUNE-MEDIATED DISEASE 209 roids in combination with anti-metabolite^.^ Diseases in which immunoglobulin M is the primary antibody involved respond better to alkylating agents. This effect is potentiated by glucocorticoids, however.…”

Section: Role Ofantibodies In Imdmentioning

confidence: 99%

Immunosuppressive Therapy in the Treatment of Immune‐mediated Disease

Miller

1992

Veterinary Internal Medicne

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Immune-mediated diseases represent some of the most frustrating types of disorders that are diagnosed and treated in veterinary medicine. Drug-induced immunosuppression is an attempt to control the aberrant immune response against self antigens but the immunosuppression can result in sepsis or other unacceptable adverse effects. If the pathophysiology of immune-mediated and autoimmune disease is considered, the immune response can be divided into several components and attempts can be made to selectively deal with each component separately. The components of the immune response that can be manipulated by therapy include antibodies, effector cells, the mononuclear phagocytic system, and the peripheral manifestations of disease. This article reviews the therapy of immune-mediated and autoimmune diseases based on a pathophysiologic approach and discusses conventional as well as current therapies in the treatment of these devastating diseases. (Journal of Veterinary Internal Medicine 1992; 6~206-213)

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Section: Role Ofantibodies In Imdmentioning

confidence: 99%

Immunosuppressive Therapy in the Treatment of Immune‐mediated Disease

Miller

1992

Veterinary Internal Medicne

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Isolation and Characterization of Three Inhibitors of Thymidine Incorporation into Bovine Fetal Liver Cells^a

Congote²

1991

Annals of the New York Academy of Sciences

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During the isolation and purification of erythroid cell-stimulating factors from fetal tissues and blood, we found that they were almost invariably contaminated with substances that inhibited thymidine incorporation into erythroid cells of fetal bovine liver. We have isolated and partially sequenced three of these inhibitory factors. The first one was a 46-kDa heparin-binding protein from fetal bovine serum with 80% sequence identity with human apolipoprotein H (apo H). Although human apo H had no inhibitory activity on thymidine incorporation, the bovine apo H-like protein inhibited thymidine incorporation with an ID50 of 36 nM. It probably belongs to a group of heparin-binding apolipoproteins such as apo B and E, which have been reported to inhibit hematopoietic cells. The second inhibitor isolated from fetal bovine serum was clearly cytotoxic at a concentration of 1 nM. This 11-kDa peptide seems to be structurally related to the anaphylatoxins. The third inhibitor was isolated from human fetal intestine. The amino-terminal sequence of this protein was nearly identical to the amino-terminal sequence of human phospholipase A2 isolated from pancreas or lung. Bovine liver erythroid cell membranes are particularly sensitive to phospholipases. Since the synthesis and secretion of phospholipase A2 has been reported to be under the control of interleukin-1 or tumor necrosis factor in different cells, it is possible that this enzyme may be secreted locally and play an important role in tissue remodeling during injury or fetal development.

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From nonspecific to specific immunosuppression facts and speculation

Cited by 2 publications

References 38 publications

Immunosuppressive Therapy in the Treatment of Immune‐mediated Disease

Immunosuppressive Therapy in the Treatment of Immune‐mediated Disease

Isolation and Characterization of Three Inhibitors of Thymidine Incorporation into Bovine Fetal Liver Cells^a

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From nonspecific to specific immunosuppression facts and speculation

Cited by 2 publications

References 38 publications

Immunosuppressive Therapy in the Treatment of Immune‐mediated Disease

Immunosuppressive Therapy in the Treatment of Immune‐mediated Disease

Isolation and Characterization of Three Inhibitors of Thymidine Incorporation into Bovine Fetal Liver Cellsa

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Isolation and Characterization of Three Inhibitors of Thymidine Incorporation into Bovine Fetal Liver Cells^a