Nucleic acid interaction and antibacterial behaviours of a ternary palladium(II) complexes

Patel, Mohan N.; Dosi, Promise A.; Bhatt, Bhupesh S.

doi:10.1016/j.saa.2011.10.077

Cited by 25 publications

(16 citation statements)

References 41 publications

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“…Minimum inhibitory concentration (MIC) values are presented in Supplementary material 9. MIC values of all synthesized complexes are in the range 45–400 μM (Figure ), which is comparable with higher‐than‐reported Pd(II) complexes (MIC = 4–81 μM) . Most synthetic compounds exhibited significant antibacterial activity.…”

Section: Resultssupporting

confidence: 72%

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

et al. 2019

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Novel palladium(II) complexes (7a–7e) of substituted quinoline derivatives were synthesized. The complexes were characterized using various techniques such as thermogravimetric analysis (TGA), elemental analysis, conductance measurement, mass, absorption, infra‐red (IR), 1H NMR, 13C NMR and energy‐dispersive X‐ray spectroscopy (EDX). Complexes for herring sperm DNA (HS DNA) binding were explored and absorption titration and the binding constant (Kb) as well as Gibb's free energy were evaluated. Complex 7d exhibited the highest binding constant, therefore the thermodynamic parameters of 7d at different temperatures were evaluated. To support the results of the absorption titration, fluorescence titration, viscosity measurement and molecular docking studies were performed. The fluorescence quenching data as evaluated from Stern–Volmer equation were used to calculate KSV, Kf and the number of binding sites. The results of all these studies were in good agreement with the absorption study. DNA electrophoretic mobility was performed to explore the possible application of metal complexes as artificial metallonucleases. The antibacterial activity of the complexes was accessed against different pathogenic bacteria and cytotoxicity was measured using brine shrimp and S. pombe.

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Section: Resultssupporting

confidence: 72%

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

et al. 2019

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“…亚甲基桥连的双吡唑配体与二价钯盐酸盐形成的络合物超分子 128 具有广谱抗菌活性, 对金黄色葡萄球菌、枯草芽孢杆菌、粘质沙雷菌(Serratia marcescens)、绿脓杆菌和大肠杆菌均有较好的抑制活性, 最小抑制浓度均在 40 μg/mL 左右 [257,294] . [295] .…”

Section: -羧基-5-苯基吡唑以及二联吡啶与金属离子形成unclassified

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Cheng¹,

Wang²,

Addla³

et al. 2016

Chin. J. Org. Chem.

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Noncovalent bond forces-based supramolecular chemistry grows quite rapidly and has been revealed to have extensively potential applications and huge development values in chemistry, physics, materials and information science, medicine and so on. Azole compounds such as imidazoles, thiazoles, oxazoles, pyrazoles, triazoles, tetrazoles and carbazoles containing special nitrogen aromatic heterocyclic structure, can exert non-covalent forces to form supramolecular complexes with inorganic and/or organic compounds and exhibit broad biological activity. In recent years, heterocyclic azole-based supramolecular complexes have been expeditiously expanding in the field of medicine, and have become a quite hot topic. Combined with our work and referring to other literature in recent 5 years, this paper systematically reviews the researches and applications of azole-based supermolecules as medicinal agents including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, anti-inflammatory drugs and other ones. Finally, the perspectives of the future development of azole-based supermolecules as medicinal agents are also presented.

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“…The FT-IR spectrum of free tptz displays three bands at 1617, 1524 and 1468 cm À1 due to the m(C@N) stretching mode of the triazine ring, and the m(C@C) and m(C@N) modes of the pyridyl rings, respectively [20]. The intense band at 1367 cm À1 is assigned to the stretching vibrations of both (1) 90.00(9) N(1)ACo(1)ACl (2) 88.69(10) N(4)ACo(1)ACl (2) 93.05(9) N(5)ACo(1)ACl (2) 89.14(10) O(1)ACo(1)ACl (2) 172.90(9) Cl(1)ACo(1)ACl (2) 96.82 (4) the triazine and pyridine rings of tptz. The FT-IR spectrum of the complex [Co(tptz)(CH 3 OH)Cl 2 ]ÁCH 3 OHÁ0.5H 2 O is very similar to that of the free tptz ligand.…”

Section: Uv-vis and Irmentioning

confidence: 99%

“…Synthesis and Evaluation of the biological activity of metal complexes incorporating biologically active ligands is subject of much current interest [1][2][3]. The use of transition metal complexes as therapeutic compounds has become more and more pronounced.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, crystal structure, antibacterial activity and theoretical studies on a novel mononuclear cobalt(II) complex based on 2,4,6-tris(2-pyridyl)-1,3,5-triazine ligand

Maghami

Farzaneh

Ghiasi

et al. 2015

Journal of Molecular Structure

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Synthesis, crystal structure, antibacterial activity and theoretical studies on a novel mononuclear cobalt(II) complex based on 2,4,6-tris(2-pyridyl)-1,3,5-triazine ligand h i g h l i g h t s A new Co(II) complex with formula [Co(tptz)(CH 3 OH)Cl 2 ]ÁCH 3 OHÁ0.5H 2 O has been prepared. Using tptz = 2,4,6-tris(2-pyridyl)-1,3,5-triazine as ligand. The antibacterial activity of Co(II), Ni(II), Cu(II), Mn(II) and Rh(III) with tptz have been evaluated. The DFT studies consistent with experimental results. g r a p h i c a l a b s t r a c tThe crystal structure of Co(II) with formula [Co(tptz)(CH 3 OH)Cl 2 ]ÁCH 3 OHÁ0.5H 2 O, (tptz = 2,4,6-tris(2-pyridyl)-1,3,5-triazine) was determined by single-crystal X-ray diffraction. The DFT studies consistent with experimental results. Then, the in vitro antibacterial activity of ligand and tptz complexes of Co(II), Ni(II), Cu(II), Mn(II) and Rh(III) have been evaluated. a b s t r a c t A cobalt complex was prepared from CoCl 2 Á6H 2 O and 2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz) in methanol and designated as [Co(tptz)(CH 3 OH)Cl 2 ]ÁCH 3 OHÁ0.5H 2 O (1). It was characterized by several techniques including TGA analysis and FT-IR, UV-Vis and 1 H NMR spectral studies. The crystal structure of 1 was determined by single-crystal X-ray diffraction. The Co(II) metal center in 1 is six coordinated with a distorted octahedral geometry. The tptz ligand is tridentate and coordinates to the cobalt through coplanar nitrogen atoms from the triazine and two pyridyl rings. Two chloride anions and a methanol molecule complete the inner coordination sphere of the metal ion. The optimized geometrical parameters obtained by DFT calculation are in good agreement with single XRD data. The in vitro antibacterial activity of various tptz complexes of Co(II), Ni(II), Cu(II), Mn(II) and Rh(III) were evaluated against Gram-positive (Bacillus subtilis, Staphylococcus aureus and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. Whereas all complexes exhibited good activity in comparison to standard antibacterial drugs, the inhibitory effects of complexes were found to be more than that of the parent ligand. Overall, the obtained results strongly suggest that the cobalt(II) complex is a suitable candidate for counteracting antibiotic resistant microorganisms.

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Nucleic acid interaction and antibacterial behaviours of a ternary palladium(II) complexes

Cited by 25 publications

References 41 publications

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Current Researches and Applications of Azole-BasedSupermolecules as Medicinal Agents

Synthesis, crystal structure, antibacterial activity and theoretical studies on a novel mononuclear cobalt(II) complex based on 2,4,6-tris(2-pyridyl)-1,3,5-triazine ligand

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