Nucleic acid functionalized fiber optic probes for sensing in evanescent wave: optimization and application

Zhu, Xiaobiao; Wang, Ruoyu; Xia, Kaidong; Zhou, Xiaoguang; Shi, Hanchang

doi:10.1039/c8ra10125f

Cited by 10 publications

(8 citation statements)

References 56 publications

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“…widely range of biomolecules such as adenosine [64], dopamine [65], nicotine [66], cancer biomarkers [67], other enzymes [68], RNA sequences [69], [70]; other compounds as heavy metal ions [71], [72]; or even physical magnitudes, such as temperature [73].…”

Section: Ssdna Receptors For Non-dna Targetsmentioning

confidence: 99%

“…All these sensors can be also classified into different types depending on their sensing methods as in previous section. Within the intensity based sensors, most of the studies recently presented are chemiluminescent or fluorescence based sensors by means of the functionalization of the end facet of optical fibers [46], [74]- [76] or evanescent wave sensors [64], [77]. Among the wavelength based sensors, some interferometers [66], [78], lossy mode resonance based devices [79], [80] and SPR based devices [81]- [85] can be found in literature.…”

Section: Ssdna Receptors For Non-dna Targetsmentioning

confidence: 99%

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Advances in Fiber Optic DNA-Based Sensors: A Review

et al. 2021

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DNA is becoming increasingly important in the domain of optical fiber sensors, either as a tool for biosensing, or as a target to detect. In this review the main contributions of the last years are presented both in the domain of wavelength and intensity based configurations. This review comprises the use of natural single strand DNA (ssDNA) sequences as receptors for the detection of ssDNA sequences through hybridization, synthetic nucleic acids receptors for detection of complementary ssDNA sequences, and sensors based on natural and synthetic ssDNA receptors used for the detection of non-DNA targets. Parameters such as sensitivity, detection range and limit of detection are analyzed and discussed in detail to the purpose of comparing the different technologies and knowing the future lines to follow in the domain of fiber optic DNA-based sensors.

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Section: Ssdna Receptors For Non-dna Targetsmentioning

confidence: 99%

Section: Ssdna Receptors For Non-dna Targetsmentioning

confidence: 99%

Advances in Fiber Optic DNA-Based Sensors: A Review

et al. 2021

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“…Optical fibres have been the substrate of choice to develop these sensors as they are compatible with several different classes of receptors. Split-aptamers have been investigated as receptors for the micromolar detection of adenosine using optical fibre substrates [159]. In comparison to conventional EW-based aptasensors [160], platforms using split aptamers [161] showed a 100-fold higher sensitivity and 2.6 times shorter assay time for small molecule detection.…”

Section: Evanescent Wave-based Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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“…Evanescent waves based sensing has always attracted the attention of the research fraternity due to its unique in-depth sensing capabilities . In particular, fiber-based evanescent wave sensors are being widely used in different types of applications. − Applications of graphene-based evanescent wave sensors in chemistry have also been proposed . On the other hand, fiber-based Raman spectroscopy allows for remote, in situ, and real-time monitoring of chemical processes .…”

Section: Introductionmentioning

confidence: 99%

Graphene Nanocomposite as Optical-Fiber Interface for the Spectroscopy of Aqueous Media: Study of the C-H Stretch

Ulin-Avila

Mishra

2021

J. Phys. Chem. C

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Spectroscopic investigation of different modes of interatomic bonds has fascinated the research fraternity for a very long time. Study of the C-H stretch has been of particular importance. Here, we present a versatile spectroscopic technique using a graphene-based interface and utilize it to investigate the different Raman modes of the C-H stretch between water molecules and reduced graphene oxide (rGO). We infer such changes by studying the Raman fingerprint and the background of the spectrum using a highly multimode optical fiber evanescent wave setup. With this, we are able to interrogate the different C-H peaks using visible excitation with good resolution. The technique we demonstrate is noninvasive and can sustain very high power to probe dormant or weak Raman oscillators. We believe our system provides the complete information on the evolution of the interface as it changes with temperature, allowing for the study of thermodynamic changes at the molecular level. This unprecedented selective excitation of different Raman active oscillators paves the way to the further exploration of the molecular dynamics happening at such an interface.

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Nucleic acid functionalized fiber optic probes for sensing in evanescent wave: optimization and application

Abstract: Reliable DNA-functionalized optic probes for sensing in evanescent wave have been developed based a series of optimizations on the etching solution and immobilization chemistry.

Cited by 10 publications

References 56 publications

Advances in Fiber Optic DNA-Based Sensors: A Review

Advances in Fiber Optic DNA-Based Sensors: A Review

Recent Progress in Optical Sensors for Biomedical Diagnostics

Graphene Nanocomposite as Optical-Fiber Interface for the Spectroscopy of Aqueous Media: Study of the C-H Stretch

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