Advances in Fiber Optic DNA-Based Sensors: A Review

Abstract

DNA is becoming increasingly important in the domain of optical fiber sensors, either as a tool for biosensing, or as a target to detect. In this review the main contributions of the last years are presented both in the domain of wavelength and intensity based configurations. This review comprises the use of natural single strand DNA (ssDNA) sequences as receptors for the detection of ssDNA sequences through hybridization, synthetic nucleic acids receptors for detection of complementary ssDNA sequences, and sensors based on natural and synthetic ssDNA receptors used for the detection of non-DNA targets. Parameters such as sensitivity, detection range and limit of detection are analyzed and discussed in detail to the purpose of comparing the different technologies and knowing the future lines to follow in the domain of fiber optic DNA-based sensors.

Multichannel Fiber Optic SPR Sensors: Realization Methods, Application Status, and Future Prospects

“…As we all know, the four different nucleotides that make up a single strand of DNA are combined with another complementary single strand through complementary pairing of respective nucleobase to form a double helix structure through hydrogen bonding. Then, by using this property of DNA, we can specifically detect certain biomarkers such as viruses or pathogenic genes [270] . In recent years, fiber optic sensors based on DNA or RNA aptamers to detect a wider range of measurement parameters have been reported many times.…”

“…Then, by using this property of DNA, we can specifically detect certain biomarkers such as viruses or pathogenic genes. [270] In recent years, fiber optic sensors based on DNA or RNA aptamers to detect a wider range of measurement parameters have been reported many times. And this technology is expected to expand the application range of DNA technology and increase the selectivity of sensors.…”

Tapered Fiber Bioprobe Based on U-Shaped Fiber Transmission for Immunoassay

“…Optical fiber biosensors have received wide attention and in-depth research because of their advantages such as fast response, high selectivity, high sensitivity, easy operation, anti-electromagnetic interference, good biocompatibility, miniaturization, and low cost [6]. Through surface functionalization with different biometric components, optical fiber biosensors can detect targets such as antigens [7], nucleic acids [8], cancer markers [9], viruses [10], bacteria [11], etc., which has important applications in the clinical, environmental, and medical fields.…”