Nucleic Acid Components and Their Analogues: A Novel and Efficient Method for the Synthesis of a New Class of Bipyridyl and Biheterocyclic‐Nitrogen Thioglycosides from Pyridine‐2(1H)‐thiones.

Abstract

1H)-thiones. -The synthesis of nonclassical bipyridyl and biheterocyclic nitrogen thioglycosides by reaction of substituted pyridinethiones with α-halosugars is described. These glycosides can be used as excellent starting compounds for the synthesis of other carbohydrate derivatives and for biological evaluation studies. -(ELGEMEIE*, G. H.; EL-ENANY, M. M.; ISMAIL, M. M.; AHMED, E.

Design, Synthesis and Cytotoxic Evaluation of Novel Heterocyclic Thioglycosides

“…Recently, a number of S-glycosides, a new non classical class of nucleosides, have been proved to be potential anticancer agents against many cell lines [17][18][19][20][21][22]. Elgemeie et al described the synthesis of series of heterocyclic thioglycosides, pyridine [33], benzisoquinoline [16] and pyrimidinthione [34] thioglycosides and revealed their potential antitumor activities. A novel dihydropyridine -S-glycoside B was identified as strong P-glycoprotein antagonist with significant cytotoxic activity against human colon carcinoma cells [20].…”