Nuclease sensitivity and methylation of liver chromatin DNA in rats in initial period of effect of glucocorticoids

Romanov, G. A.; Zhavoronkova, E. N.; Savel’ev, S. V.; Vanyushin, B. F.

doi:10.1007/bf01148168

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2008

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“…This epigenetic modification, which is a conserved change to DNA,5 influences chromatin structure6–8 and mediates gene expression 9. Many tumors exhibit altered methylation patterns, leading to activation of proto-oncogenes and silencing of tumor suppressor genes 10.…”

Section: Introductionmentioning

confidence: 99%

Density functional study of the influence of C5 cytosine substitution in base pairs with guanine

et al. 2008

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The present study employs density-functional electronic structure methods to investigate the effect of chemical modification at the C5 position of cytosine. A series of experimentally motivated chemical modifications are considered, including alkyl, halogen, aromatic, fused ring, and strong σ and π withdrawing functional groups. The effect of these modifications on cytosine geometry, electronic structure, proton affinities, gas phase basicities, cytosine-guanine base-pair hydrogen bond network and corresponding nucleophilicity at guanine are examined. Ultimately, these results play a part in dissecting the effect of endogenous cytosine methylation on the reactivity of neighboring guanine toward carcinogens and DNA alkylating agents.

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