Nuclear magnetic resonance at millitesla fields using a zero-field spectrometer

Tayler, Michael C. D.; Sjolander, Tobias F.; Pines, Alexander; Budker, Dmitry

doi:10.1016/j.jmr.2016.05.010

Cited by 29 publications

(17 citation statements)

References 43 publications

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“…Although HP NMR spectroscopy has been reported in the ZULF regime [37, 66, 67] including frequency-selective RF excitation [67], the use of conventional MRI frequency encoding in ZULF potentially is challenging due to the very low resonance frequency, and new MRI encoding techniques likely need to be developed. However, 13 C (as well as 1 H, 3 He and 129 Xe) MRI imaging can be performed at B 0 > 6 mT (including ~48.7 mT, the field studied here) as has been demonstrated by us [15, 52, 68–70] and others [8, 19, 20, 71–75] previously using conventional MRI approaches.…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, lowering the field strength confers the benefit of reducing SAR to potentially negligible levels [11], which not only alleviates patient safety concerns, but can also lead to design and implementation of faster pulse sequences by permitting use of RF pulses for echoes instead of gradient echoes [11]. Third, through utilizing long-lived spin states (LLSS) [25–36] or taking advantage of reduced contributions from chemical shift anisotropy particularly below 0.1 T [37], hyperpolarized state lifetimes can significantly extend for protons and/or heteronuclei at low magnetic fields. Fourth, experimental validation of the theoretical equations for low-field NMR and MRI [12, 13] sensitivity for hyperpolarized states has favorably corroborated the weak frequency dependence of hyperpolarized state detection, where these theories indicate the potential for approaching or even exceeding the sensitivity of high-field NMR/MRI [12, 13].…”

Section: Introductionmentioning

confidence: 99%

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High-resolution hyperpolarized in vivo metabolic 13C spectroscopy at low magnetic field (48.7 mT) following murine tail-vein injection

Coffey

Feldman

Shchepin

et al. 2017

Journal of Magnetic Resonance

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High-resolution 13C NMR spectroscopy of hyperpolarized succinate-1-13C is reported in vitro and in vivo using a clinical-scale, biplanar (80 cm-gap) 48.7 mT permanent magnet with a high homogeneity magnetic field. Non-localized 13C NMR spectra were recorded at 0.52 MHz resonance frequency over the torso of a tumor-bearing mouse every 2 seconds. Hyperpolarized 13C NMR signals with linewidths of ~3 Hz (corresponding to ~6 ppm) were recorded in vitro (2 mL in a syringe) and in vivo (over a mouse torso). Comparison of the full width at half maximum (FWHM) for 13C NMR spectra acquired at 48.7 mT and at 4.7 T in a small-animal MRI scanner demonstrates a factor of ~12 improvement for the 13C resonance linewidth attainable at 48.7 mT compared to that at 4.7 T in vitro. 13C hyperpolarized succinate-1-13C resonance linewidths in vivo are at least one order of magnitude narrower at 48.7 mT compared to those observed in high-field (≥ 3 T) studies employing HP contrast agents. The demonstrated high-resolution 13C in vivo spectroscopy could be useful for high-sensitivity spectroscopic studies involving monitoring HP agent uptake or detecting metabolism using HP contrast agents with sufficiently large 13C chemical shift differences.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High-resolution hyperpolarized in vivo metabolic 13C spectroscopy at low magnetic field (48.7 mT) following murine tail-vein injection

Coffey

Feldman

Shchepin

et al. 2017

Journal of Magnetic Resonance

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“…Also imaging in the vicinity of metals is possible without distortion artefacts 35 . The sensitivity of different magnetic field detectors used for ULF MRI 36 , 37 , such as for example atomic magnetometers, is comparable to the already widely used SQUIDs. A SQUID-based system has not only a higher signal to noise ratio (SNR) compared to a system using a Faraday coil at ULF 38 , but also can detect the NMR signal of multiple nuclei simultaneously.…”

Section: Introductionmentioning

confidence: 99%

SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange

Buckenmaier

Rudolph

Back

et al. 2017

Sci Rep

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Ultra-low-field (ULF) nuclear magnetic resonance (NMR) is a promising spectroscopy method allowing for, e.g., the simultaneous detection of multiple nuclei. To overcome the low signal-to-noise ratio that usually hampers a wider application, we present here an alternative approach to ULF NMR, which makes use of the hyperpolarizing technique signal amplification by reversible exchange (SABRE). In contrast to standard parahydrogen hyperpolarization, SABRE can continuously hyperpolarize 1 H as well as other MR-active nuclei. For simultaneous measurements of 1 H and 19 F under SABRE conditions a superconducting quantum interference device (SQUID)-based NMR detection unit was adapted. We successfully hyperpolarized fluorinated pyridine derivatives with an up to 2000-fold signal enhancement in 19 F. The detected signals may be explained by two alternative reaction mechanisms. SABRE combined with simultaneous SQUID-based broadband multinuclear detection may enable the quantitative analysis of multinuclear processes.

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“…34,35 Given the fact that achieving homogeneity is easier at zero field than at high field, ZULF NMR is a suitable technique for distinguishing molecules in liquid state and detecting and characterizing weak physical interactions. While ZULF NMR measurements can be performed on samples initially prepolarized by placing them in a permanent magnet before the measurement, 36 the downside of this approach is that the sample has to be shuttled. This hinders measurements during and shortly after prepolarization and limits polarization values to only ∼ 10 −6 , insufficient for many problems at hand.…”

Section: In Situ Detectionmentioning

confidence: 99%

Towards Large-Scale Steady-State Enhanced Nuclear Magnetization with In Situ Detection

Blanchard¹,

Ripka²,

Suslick³

et al. 2021

Preprint

Self Cite

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<div>Signal Amplification By Reversible Exchange (SABRE) boosts NMR signals of various nuclei enabling new applications spanning from magnetic resonance imaging to analytical chemistry and fundamental physics. SABRE is especially well positioned for continuous generation of enhanced magnetization on a large scale, however, several challenges need to be addressed for accomplishing this goal. Specifically, SABRE requires (i) a specialized catalyst capable of reversible H<sub>2</sub> activation and (ii) physical transfer of the sample from the point of magnetization generation to the point of detection (e.g., a high-field or a benchtop NMR spectrometer). Moreover, (iii) continuous parahydrogen bubbling accelerates solvent (e.g., methanol) evaporation, thereby limiting the experimental window to tens of minutes per sample.</div><div>In this work, we demonstrate a strategy to rapidly generate the best-to-date precatalyst (a compound that is chemically modified in the course of the reaction to yield the catalyst) for SABRE, [Ir(IMes)(COD)Cl] (IMes = 1,3-bis-(2,4,6-trimethylphenyl)-imidazol-2-ylidene, COD = cyclooctadiene) via a highly accessible synthesis. Second, we measure hyperpolarized samples using a home-built zero-field NMR spectrometer and study the field dependence of hyperpolarization directly in the detection apparatus, eliminating the need to physically move the sample during the experiment. Finally, we prolong the measurement time and reduce evaporation by presaturating parahydrogen with the solvent vapor before bubbling into the sample. These advancements extend opportunities for exploring SABRE hyperpolarization by researchers from various fields and pave the way to producing large quantities of hyperpolarized material for long-lasting detection of SABRE-derived nuclear magnetization.</div>

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Nuclear magnetic resonance at millitesla fields using a zero-field spectrometer

Cited by 29 publications

References 43 publications

High-resolution hyperpolarized in vivo metabolic 13C spectroscopy at low magnetic field (48.7 mT) following murine tail-vein injection

High-resolution hyperpolarized in vivo metabolic 13C spectroscopy at low magnetic field (48.7 mT) following murine tail-vein injection

SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange

Towards Large-Scale Steady-State Enhanced Nuclear Magnetization with In Situ Detection

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