Nuclear Imaging in Pediatric Kidney Diseases

Dhull, Rachita Singh; Joshi, Aparna; Saha, Abhijeet

doi:10.1007/s13312-018-1303-7

Cited by 14 publications

(13 citation statements)

References 26 publications

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“…U/S is an application of Doppler Effect and does not involve administration of nephrotoxic contrast agents or radiation used to diagnose like polycystic kidney disease, pyelonephritis, crystal renal lesions, renal artery stenosis and hydronephrosis. On the other hand, U/S is highly operator expertise oriented and results might be affected by extra-renal features such as arterial stiffness, atherosclerosis age, and BMI (Body Mass Index) [8,9,10,11].…”

Section: Evaluation Of Renal Abnormalities Through Noninvasive Procedmentioning

confidence: 99%

A correlation study of the effectiveness of renal scintigraphy and sonography in the detection and evaluation of renal disorders

Alsubhi

Alghanmi

Alzabidi

et al. 2020

Preprint

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Background: This retrospective study was undertaken to assess correlation between renal scintigraphy employing technetium Tc-99m chelated with radiopharmaceutical drug Diethylenetriamine Penta Acetic Acid (DTPA) and renal ultrasonography morphological findings. Methods: For this purpose, ninety six patients imaging data was statistically analyzed including 43 females and 53 males. All the patients were subjected to renal scintigraphy while 68 patients underwent renal ultrasonography. Renal U/S reported anatomical renal anomaly in 94.1% patients versus 85.4% detected by scintigraphy. There were 41 patients out of 68 diagnosed with hydronephrosis and 21 of them were suffering with mild hydronephrosis as suggested by U/S imaging. Results: Renal scintigraphy of 41 hydronephrotic patients validated that 19 patients having non-obstructive bilateral pelvic dilation while remaining 22 with mild to severe obstruction. Ultrasonography diagnosed 4 patients with renal obstruction. Conversely, renal scintigraphy validated 2 of them with renal obstruction on the basis of renal function. In total, 19 out 96 patients were reported with renal obstruction through scintigraphy and validated obstruction in 1 of the 3 patients who were diagnosed with abnormal postvoid residual volume through U/S. Conclusion: Renal scintigraphy is not significant in diagnosing kidney disease; rather this is a vibrant imaging tool providing supplementary data on the basis of renal function. Effectively targeted intervention regime can be achieved by correlating renal scintigraphy and renal ultrasonography results to minimize renal disease incidence.

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Section: Evaluation Of Renal Abnormalities Through Noninvasive Procedmentioning

confidence: 99%

A correlation study of the effectiveness of renal scintigraphy and sonography in the detection and evaluation of renal disorders

Alsubhi

Alghanmi

Alzabidi

et al. 2020

Preprint

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“…Molecular nuclear medicine of the urinary tract focuses on conventional imaging techniques of the kidney [ 8 ]. In past years, bladder imaging has mainly been limited to the identification of vesicoureteral reflux as a cause of recurrent urinary tract infections [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment

et al. 2021

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Diagnostic imaging in bladder cancer plays an important role since it is needed from pretreatment staging to follow-up, but a morphological evaluation performed with both CT and MRI showed low sensitivities and specificities in detecting pathologic lymph nodes, due to the occurrence of false positive results. Implementation of functional information provided by PET/CT could be a determinant in the management of patients with muscle-invasive bladder cancer. A focus on the role of 18F-FDG PET/CT and alternative tracers in patients with muscle-invasive bladder cancer is provided in this analysis in order to outline its potential applications in staging settings and response evaluation after neoadjuvant chemotherapy.

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“…The diagnostic nuclear medicine procedures that are widely used in the pediatric population are Technetium-99m-dimercapto succinic acid (Tc-99m DMSA), Technetium-99-m-diethylenetriamine pentaacetic acid (Tc-99m DTPA) and, Technetium-99m-mercaptoacetyltriglycine (Tc-99m MAG-3) (7). DMSA plays an essential role in the assessment of renal scars in febrile urinary tract infections and differential function of kidneys.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Tc-99m Dmsa Scintigraphy on Dna Damage and Oxidative Stress in Children

varol¹,

Öktem

Koçyiğit

et al. 2021

Preprint

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Background: Tc-99m DMSA scintigraphy is a commonly used imaging modality in the pediatric population. The radiopharmaceuticals which have the effects of ionizing are used in this method. This study aimed to investigate the impact of the Tc-99m DMSA scan on renal oxidative stress and mononuclear leukocyte DNA damage. Methods: Twenty-seven patients who performed Tc-99m DMSA scintigraphy were included in this study. Three ml heparinized blood samples were taken just before, during, and after a week from the scintigraphy. Mononuclear leukocyte(MNL) DNA damage, total antioxidant status (TAS), and total oxidant status(TOS) were measured in blood samples. The oxidative stress index (OSI) was calculated. The spot urine samples were taken from each patient before and within three days after performing the scintigraphy. TAS/Creatinine(TAS/Cr), TOS/Creatinin(TOS/Cr), and N-acetyl-glucosaminidase/creatinine(NAG/Cr) levels were measured in urine samples. OSI was calculated. Results: There was no statistically significant difference in the values of TAS, TOS and OSI studied in serum samples between controls and study group(p=0.105, p=0.913, and p=0.721, respectively). There was no statistically significant difference in the levels of TAS/Cr, TOS/Cr, NAG/Cr, and OSI which were studied in urine samples before and after scintigraphy scan(p=0.381, p=0.543, p=0.129 and p=0.08 respectively). The levels of DNA damage were increased only after the performance of the scintigraphy scan and decreased a week later(p<0.05). Conclusions: The effect of Tc-99m DMSA scintigraphy is insufficient to create oxidative damage, but it can cause DNA damage via the direct impact of ionizing radiation which can be repaired again in a short time. Keywords: Tc-99m DMSA, DNA damage; reactive oxygen species; renal tubular injury; children

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Nuclear Imaging in Pediatric Kidney Diseases

Cited by 14 publications

References 26 publications

A correlation study of the effectiveness of renal scintigraphy and sonography in the detection and evaluation of renal disorders

A correlation study of the effectiveness of renal scintigraphy and sonography in the detection and evaluation of renal disorders

The Role of Molecular Imaging in a Muscle-Invasive Bladder Cancer Patient: A Narrative Review in the Era of Multimodality Treatment

The Impact of Tc-99m Dmsa Scintigraphy on Dna Damage and Oxidative Stress in Children

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