Nuclear emission microscopies

Doyle, B.L.; Walsh, D.S.; Renfrow, S. N.; Vizkelethy, György; Schenkel, T.; Hamza, A. V.

doi:10.1016/s0168-583x(01)00535-3

Cited by 19 publications

(8 citation statements)

References 17 publications

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“…An unfocused ion beam (several hundred lm diameter) is used, and secondary particles (electrons or photons) produced by the ion hit are projected at high magnification and detected by a position sensitive detector. The resulting data gives an x-position, y-position, and analysis signal, nearly identical to the information obtained by traditional nuclear microscopy [1][2][3]. The technique to be discussed in this paper is ion photon emission microscopy (IPEM), and more detailed information about the IPEM can be found in references [3][4][5].…”

Section: Introductionmentioning

confidence: 55%

“…linear energy transfer), which, together with the LET spectrum in space, provides the probability of failure for space-based ICs when combined with the space LET spectrum. However, the whole device is irradiated, thus researchers are unable to pinpoint specific radiation-sensitive regions, especially when the SEE cross section is low [1,2].…”

Section: Introductionmentioning

confidence: 99%

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The ion photon emission microscope on SNL’s nuclear microprobe and in LBNL’s cyclotron facility

Branson

Doyle

Vizkelethy

et al. 2009

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Introductionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

The ion photon emission microscope on SNL’s nuclear microprobe and in LBNL’s cyclotron facility

Branson

Doyle

Vizkelethy

et al. 2009

Nuclear Instruments and Methods in Physics Research Section B:

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“…This new approach will provide high statistics, is inexpensive, and offers reliable operation. This new approach is an extension of an idea of Doyle et al at Sandia National Laboratories, who proposed that nuclear microscopy can be performed without microbeams [3,4]. An early suggestion to apply this microscopy to radiobiology can be found in ref.…”

Section: Random Irradiationmentioning

confidence: 94%

Single Cell Irradiation Nuclear Microscopy Using a Radioactive Source

Rossi¹,

Doyle²,

Banks³

et al. 2003

AIP Conference Proceedings

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Efficient negative-ion sources for radioactive ion beam applications (abstract) Rev. Sci. Instrum. 73, 796 (2002); Abstract. Irradiation of a single biological cell, instead of a whole tissue, with ions in a known number and position, is a powerful means to study very low dose biological effectiveness. Present methods employ accelerated ion beams which are 1) either collimated with micro-apertures and affected by a halo of 3-5 m at best, or 2) focused to a sub-micron spot, whose resolution is degraded when extracted into air. We have studied the efficacy of a new micro-radiobiological method, originally developed for materials research. This new approach uses an IPEM, Ion Photon Emission Microscope, which employs a specially shaped Po-210 alpha particle source for in-air irradiation. Alpha particles strike the cells, which are previously grown directly on a 10-20 m thick scintillating plastic blade and placed in the focal plane of a conventional optical microscope. Photons produced at the single ion impact point are projected at high magnification onto a single-photon position sensitive detector, which provides the position of each ion that hits the cells. Adequacy of this setup for Single Cell Radio-Biology will be discussed.

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“…A different way to perform mapping has been proposed by SNL and known as the Ion Photon Emission Microscopy (IPEM) [5][6][7]. To observe the map, it is not necessary to focus the beam at all.…”

Section: Introduction 11 Ion Photon Emission Microscopymentioning

confidence: 99%

Diamonds Utilized in the Development of Single Ion Detector with High Spatial Resolution

Onoda

Yamamoto

Ohshima

et al. 2012

Trans. Mat. Res. Soc. Japan

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We are developing the Ion Photon Emission Microscopy (IPEM) system at JAEA. To observe a map by IPEM, the position where an ion strikes a scintillator placed over a microelectronics circuit is recorded together with the ion induced event. Since the spatial resolution is determined by the spot size of the Ion Beam Induced Luminescence (IBIL), the scintillator is one of the most important parts of IPEM. In this study we propose that a diamond containing a high concentration of Nitrogen Vacancy (NV) centers can be used as a scintillator with high spatial resolution. For both Y 3 Al 5 O 12 :Ce (YAG:Ce) and the diamond containing NV centers, the minimum spot size is a few micrometers. The IBIL intensity from the diamond containing NV centers is higher than that from YAG:Ce. According to these results, we suggest that a diamond containing NV centers is a rival candidate of a YAG:Ce from the point of view of single ion detection with high spatial resolution.

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Nuclear emission microscopies

Cited by 19 publications

References 17 publications

The ion photon emission microscope on SNL’s nuclear microprobe and in LBNL’s cyclotron facility

The ion photon emission microscope on SNL’s nuclear microprobe and in LBNL’s cyclotron facility

Single Cell Irradiation Nuclear Microscopy Using a Radioactive Source

Diamonds Utilized in the Development of Single Ion Detector with High Spatial Resolution

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