Nuchal Nevus flammeus and Alopecia areata

Orecchia, G.; Perfetti, L.

doi:10.1159/000248323

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…The association between AA and NNF was statistically significant in the studies by Hatzis et al [10], Orecchia and Perfetti [11] and Camacho and Navas [12]. All the above studies [10,11,12] showed that NNF was more prevalent in severer forms of AA. NNF was less prevalent in patients with AA than controls in the study of Van Baar et al [13].…”

Section: Discussionmentioning

confidence: 89%

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The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

et al. 2005

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Background: The association of alopecia areata (AA) with nuchal nevus flammeus (NNF) has been demonstrated by previous studies. Objectives: The aim of this study was to investigate whether AA is associated with NNF. Methods: 199 AA patients and 215 controls without AA were examined for the presence of NNF. Results: 35 patients (17.6%) in the AA group had NNF. In the control group, 20 patients (9.3%) had NNF (odds ratio = 2.08, 95% confidence interval 1.43–2.73; p = 0.013). A statistically significant association was found between the presence of NNF and duration of the AA (p < 0.001). The presence of NNF was associated with severity of AA (p < 0.001). Conclusions: The results of our study suggest a link between NNF and AA especially in severer and more chronic forms.

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Section: Discussionmentioning

confidence: 89%

“…Studies showed that the prevalence of nuchal nevus flammeus (NNF) was significantly increased in patients with AA, especially severer forms [10,11,12]. We also conducted a study to investigate whether AA is associated with NNF.…”

Section: Introductionmentioning

confidence: 99%

The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

et al. 2005

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“…Nevertheless Roller [27] reported more umbilical hernias and hyperextensions of the joints in infants with MTVN. Orecchia and Perfetti [28] observed a relationship between a persistent nuchal MTVN, alopecia areata and onycho pathy.…”

Section: Family Historymentioning

confidence: 98%

Sacral Medial Telangiectatic Vascular Nevus: A Study of 43 Children

Patrizi¹,

Neri²,

Orlandi³

et al. 1996

Dermatology

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Background: Medial telangiectatic vascular nevi are capillary vascular malformations frequently observed at birth occurring mostly on the face or on the nape as a single lesion or as multiple macules affecting more than one site simultaneously. In 1990, Metzker and Shamir reported a medial telangiectatic vascular nevus (MTVN) in the sacral region along the midline and called this particular variety of MTVN ‘butterfly-shaped mark’. Objective: Our study was performed to investigate the morphology and localization of an MTVN in the sacral region (sMTVN) in a group of Caucasian children. Methods: We observed 43 children with sMTVN, ranging in age from 1 month to 12 years (mean 8 years), for a period of 6 years. Results: sMTVN was found as a red-violet macular lesion of rhomboid or triangular shape in 16 patients and as a group of little red-violet macules in 10 patients. In 16 patients moreover the whole back was involved with many small red-violet spots on and around the spinal column, and in 1 patient with classic sMTVN satellite macules were also present over both buttocks. Four patients suffered from epilepsy with mental deficiency. In 6 patients, the family history showed sMTVN in one or more members of the family. No case presented an association with spina bifida. Conclusion: In our study, sMTVN shows a morphological polymorphism while Metzker and Shamir reported the same clinical aspect in all 25 of their patients. In accordance with these authors, we noted that sMTVN persist into childhood and adult life in the same way as occipital MTVN.

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“…Since persistent NNF varies in size and color, we have observed a direct correlation over the years, not only between the presence of the NNF and the severity of AA but also between the size of the NNF and the severity of AA, which could be a useful marker of widespread and chronic disease. Orecchia and Perfetti[9] classified NNF into the faint, medium and marked, and failed to correlate it with the severity of the disease; however, to our knowledge, there are no publications associating the size of the NNF and the severity of AA.…”

Section: Introductionmentioning

confidence: 94%

“…in 1988,[2] who demonstrated that the relation was statistically evident and not due to a simple observer bias[8] (owing to the much more noticeable NNF in the naked occipital region, and the high prevalence of both NNF and AA), a theory that has been supported by further publications. [12349]…”

Section: Introductionmentioning

confidence: 99%

Nuchal nevus flammeus and alopecia areata: When size matters

et al. 2018

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Introduction:Alopecia areata (AA) is a high-prevalence immuno-mediated hair loss disorder. Extra follicular affections, including nail and ocular abnormalities, are classically related to a worse prognosis of the disease, and previous studies have suggested that the presence of a persistent nuchal nevus flammeus (NNF) also indicates a greater severity and duration of the disease. The association between AA and persistent NNF was first described by Hatzis et al in 1988, who demonstrated that the relation was statistically evident and not due to a simple observer bias.Objectives:To determine and compare the presence/absence and size of the NNF in 80 individuals (40 patients diagnosed with AA and 40 controls).Results:We found a statistically significant association not only between AA and the presence of NNF, but also with its size. Moreover, we found that the size of the NNF was also associated with the severity of AA.Conclusion:The size of the NNF in AA patients might be a useful marker of widespread and chronic disease.

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Nuchal Nevus flammeus and Alopecia areata

Cited by 9 publications

References 6 publications

The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

The Association between Nuchal Nevus Flammeus and Alopecia Areata: A Case-Control Study

Sacral Medial Telangiectatic Vascular Nevus: A Study of 43 Children

Nuchal nevus flammeus and alopecia areata: When size matters

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