NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps

McKee, Richard H.; Butala, John H.; David, Raymond M.; Gans, Gerhard

doi:10.1016/j.reprotox.2003.09.002

Cited by 128 publications

(54 citation statements)

References 85 publications

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“…Furthermore, their metabolites are suspected endocrine disrupting chemicals exhibiting carcinogenic action (McKee et al, 2004). Human Leydig cell development and function may be vulnerable and incomplete virilization in infant boys due to perinatal exposure to some phthalates (Main et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Soil contamination by phthalate esters in Chinese intensive vegetable production systems with different modes of use of plastic film

Wang

Luo

Teng

et al. 2013

Environmental Pollution

293

125

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a b s t r a c tThe concentrations of six priority phthalic acid esters (PAEs) in intensively managed suburban vegetable soils in Nanjing, east China, were analyzed using gas chromatographyemass spectrometry (GCeMS). The total PAE concentrations in the soils ranged widely from 0.15 to 9.68 mg kg À1 with a median value of 1.70 mg kg À1 , and di-n-butyl phthalate (DnBP), bis-(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP) were the most abundant phthalate esters. Soil PAE concentrations depended on the mode of use of plastic film in which PAEs were incorporated as plasticizing agents and both the plastic film and poultry manure appeared to be important sources of soil PAEs. Vegetables in rotation with flooded rice led to lower concentrations of PAEs in soil. The results indicate that agricultural plastic film can be an important source of soil PAE contamination and further research is required to fully elucidate the mechanisms of PAE contamination of intensive agricultural soils with different use modes of use of plastic film.Crown

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Section: Introductionmentioning

confidence: 99%

Soil contamination by phthalate esters in Chinese intensive vegetable production systems with different modes of use of plastic film

Wang

Luo

Teng

et al. 2013

Environmental Pollution

293

125

View full text Add to dashboard Cite

show abstract

“…Di(2-ethylhexyl)phthalate (DEHP), a phthalate derivative and a well-known peroxisome proliferator (PP), is widely used as a plasticizer in the manufacture of PVC plastics. Its widespread use leads to significant human exposures through contaminated foods, food packaging, or medical products (Koo and Lee, 2004;McKee et al, 2004;Silva et al, 2006). DEHP is rapidly metabolized to its major metabolite mono(2-ethylhexyl)phthalate (MEHP) in liver, and MEHP is even more toxic than the parent compound.…”

Section: Introductionmentioning

confidence: 99%

Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds

Erkekoğlu

Rachidi

Yuzugullu

et al. 2011

Food and Chemical Toxicology

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Keywords: DEHP MEHP p53 p21 ROS Selenium a b s t r a c t This study was designed to investigate the hypothesis that the toxic effects of di(2-ethylhexyl)phthalate (DEHP), the most abundantly used plasticizer and ubiquitous environmental contaminant that cause alterations in endocrine and spermatogenic functions in animals is mediated through the induction of reactive oxygen species (ROS) and activation of nuclear p53 and p21 proteins in LNCaP human prostate adenocarcinoma cell line. Protective effects of two selenocompounds, sodium selenite (SS) and selenomethionine (SM) were also examined. It was demonstrated that 24 h exposure of the cells to 3 mM DEHP or its main metabolite, mono(2-ethylhexyl)phthalate (MEHP, 3 lM) caused strongly amplified production of ROS. Both SS (30 nM) and SM (10 lM) supplementations reduced ROS production, and p53 and p21 activation that induced significantly only by MEHP-exposure. The overall results of this study indicated that the induction of oxidative stress is one of the important mechanisms underlying the toxicity of DEHP and this is mainly through the effects of the metabolite, MEHP. Generated data also emphasized the critical role of Se in modulation of intracellular redox status, implicating the importance of the appropriate Se status in cellular response against testicular toxicity of phthalates.

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“…Therefore, the concentration in surface and ground water are usually less than 10 ppb and rarely exceed 10 ppm (Hites, 1973;Lopez Roldan et al, 2004;Mihovec Grdic et al, 2002).…”

Section: Surface Watermentioning

confidence: 99%

“…Empirical data, although limited, have demonstrated a positive associations between the magnitude of exposure and the use of PVC containing tubing, catheters, and gloves (Green et al, 2005;Tsumura et al, 2001b). FDA has judged a tolerable intake (TI) value of 0.6 mg/kg/day for DEHP (McKee et al, 2004). Many medical procedures in current practice could lead to exposure levels approaching or exceeding the TI.…”

Section: Q Should I Be Concerned About Exposure From Medical Devices?mentioning

confidence: 99%

Phthalates in food and medical devices

Chou

Wright

2006

J. Med. Toxicol.

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NTP center for the evaluation of risks to human reproduction reports on phthalates: addressing the data gaps

Cited by 128 publications

References 85 publications

Soil contamination by phthalate esters in Chinese intensive vegetable production systems with different modes of use of plastic film

Soil contamination by phthalate esters in Chinese intensive vegetable production systems with different modes of use of plastic film

Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds

Phthalates in food and medical devices

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