NT-proBNP and the anti-inflammatory cytokines are correlated with endothelial progenitor cells’ response to cardiac surgery

Cesari, Francesca; Caporale, Roberto; Marcucci, Rossella; Caciolli, Sabina; Stefàno, Pier Luigi; Capalbo, Andrea; Macchi, Claudio; Vannucci, Mauro; Gensini, Gian Franco; Abbate, Rosanna; Gori, Anna Maria

doi:10.1016/j.atherosclerosis.2007.09.045

Cited by 26 publications

(26 citation statements)

References 23 publications

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“…Mieno et al [36] reported increase in CD34+CXCR4+ cell population in a sample collected at 4 h after surgery with return to baseline on the 4th postoperative day. In a study of Cesari et al [38] CD34+CD133+ cells increased 72 h after surgery and maintained this rise when measured again on the 10th postoperative day. Notably, in the same study, triple-positive cells (CD34+CD133+VEGF2+), referred by the authors as EPCs, have decreased at 72 h after surgery and returned to preoperative level by 10th postoperative day [38].…”

Section: Quantitative Changes Of Stem Cells After Cardiac Surgerymentioning

confidence: 80%

“…However, observational clinical data are increasing. So far, seven clinical studies, describing the effects of cardiac surgery on stem/progenitor cells and/or on stem cell regulative cyto-/chemokines and growth factors, have been reported [18,[34][35][36][37][38][39] (Table 1).…”

Section: Stem/progenitor Cells In Patients Undergoing Cardiac Surgerymentioning

confidence: 98%

“…Several observational studies in patients undergoing cardiac surgery have reported increase in the level of circulating stem cells after surgery [18,[34][35][36][37][38][39]. Currently, the mechanisms of this phenomenon and possibility of its clinical application are not defined.…”

Section: Introductionmentioning

confidence: 94%

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Endogenous stem cells in patients undergoing coronary artery bypass graft surgery

Dotsenko

Jahangiri

2009

European Journal of Cardio-Thoracic Surgery

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Considerable research efforts have recently been made towards the application of autologous stem cell therapy for cardiovascular regeneration. Patients with coronary artery disease undergoing surgery represent a potential target. As yet, this approach has failed to obtain satisfactory evidence in clinical studies. However, several observational studies have described mobilising effect of cardiac surgery on endogenous stem cells, although the mechanisms of this phenomenon and its clinical relevance are not defined. This article reviews available clinical data on the effect of cardiac surgery on endogenous stem cells and outlines some of the controversies in this area.

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Section: Quantitative Changes Of Stem Cells After Cardiac Surgerymentioning

confidence: 80%

Section: Stem/progenitor Cells In Patients Undergoing Cardiac Surgerymentioning

confidence: 98%

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Endogenous stem cells in patients undergoing coronary artery bypass graft surgery

Dotsenko

Jahangiri

2009

European Journal of Cardio-Thoracic Surgery

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“…Because inflammatory events are known to influence EPC number, 32 blood was withdrawn after excluding the occurrence of infectious events (defined according to previously published criteria 33 ) in the previous 15 days.…”

Section: Blood Collectionmentioning

confidence: 99%

“…32,34 Briefly, 200 L of peripheral venous blood was incubated for 20 minutes in the dark with the appropriated monoclonal antibodies and 300 000 cells within the leukocyte gate were acquired using a FACSCanto analyzer (Becton Dickinson, San Jose, Calif). Data were processed using BD FacsDiva software.…”

Section: Flow Cytometric Analysis Of Epcs and Cpcsmentioning

confidence: 99%

Bone Marrow-Derived Progenitor Cells in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Pescini

Cesari

Giusti

et al. 2010

Stroke

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Background and Purpose— Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited disease due to cerebral microangiopathy presenting with variable pictures, including stroke, progressive cognitive impairment, and disability. Mechanisms leading from vessel structural changes to parenchymal damage and eventually to clinical expression are not fully understood. Among pathogenic processes, endothelial dysfunction has been hypothesized. Endothelial progenitor cells and circulating progenitor cells (CPCs) derived from bone marrow participate in endothelium structure and function maintenance and contribute to ischemic area revascularization. No data are available about these cells in CADASIL. Our objective in this study was to evaluate endothelial progenitor cells and CPCs role in CADASIL. Methods— Twenty-nine patients with CADASIL and 29 sex- and age-matched control subjects were enrolled. Cells were measured in peripheral blood using flow cytometry. Endothelial progenitor cells were defined as positive for CD34/KDR, CD133/KDR, and CD34/CD133/KDR; and CPCs as positive for CD34, CD133, and CD34/CD133. Results— Endothelial progenitor cells were significantly lower in patients with CADASIL than in control subjects (CD34/KDR: 0.05 versus 0.1 cells/μL, P =0.005; CD133/KDR: 0.07 versus 0.1 cells/μL, P =0.006; CD34/CD133/KDR: 0.05 versus 0.1 cells/μL, P =0.001). The difference remained significant after adjusting for age, sex, and statin use. CPCs were not significantly lower in CADASIL, but patients with stroke or dementia had significantly reduced CPC levels than patients without (CD34: 1.68 versus 2.95 cells/μL, P =0.007; CD133: 1.40 versus 2.82 cells/μL, P =0.004; CD34/CD133: 1.44 versus 2.75 cells/μL, P =0.004). CPC levels significantly correlated with cognitive and motor performance measures. Conclusions— We have documented an association between endothelial progenitor cells and CPCs and CADASIL, extending previous data about the presence of endothelial dysfunction in this disease and its potential role in modulating phenotype.

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Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction

et al. 2011

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Endothelial colony-forming cells (ECFCs) are known to increase after acute myocardial infarction (AMI). We examined whether the presence of ECFCs is associated with preserved microvascular integrity in the myocardium at risk by reducing microvascular obstruction (MVO). We enrolled 88 patients with a first ST elevation AMI. ECFC colonies and circulating progenitor cells were characterized at admission. MVO was evaluated at 5 days and infarct size at 5 days and at 6-month follow-up by magnetic resonance imaging. ECFC colonies were detected in 40 patients (ECFC(pos) patients). At 5 days, MVO was of greater magnitude in ECFC(neg) versus ECFC(pos) patients (7.7 ± 5.3 vs. 3.2 ± 5%, p = 0.0002). At 6 months, in ECFC(pos) patients, there was a greater reduction in infarct size (-32.4 ± 33 vs. -12.8 ± 24%; p = 0.003) and a significant improvement in left ventricular (LV) volumes and ejection fraction. Level of circulating CD34+/VEGF-R2+ cells was correlated with the number of ECFC colonies (r = 0.54, p < 0.001) and relative change in infarct size (r = 0.71, p < 0.0001). The results showed that the presence of ECFC colonies is associated with reduced MVO after AMI, leading to reduced infarct size and less LV remodelling and can be considered a marker of preserved microvascular integrity in AMI patients.

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NT-proBNP and the anti-inflammatory cytokines are correlated with endothelial progenitor cells’ response to cardiac surgery

Cited by 26 publications

References 23 publications

Endogenous stem cells in patients undergoing coronary artery bypass graft surgery

Endogenous stem cells in patients undergoing coronary artery bypass graft surgery

Bone Marrow-Derived Progenitor Cells in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction

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