Endogenous stem cells in patients undergoing coronary artery bypass graft surgery

Abstract

Considerable research efforts have recently been made towards the application of autologous stem cell therapy for cardiovascular regeneration. Patients with coronary artery disease undergoing surgery represent a potential target. As yet, this approach has failed to obtain satisfactory evidence in clinical studies. However, several observational studies have described mobilising effect of cardiac surgery on endogenous stem cells, although the mechanisms of this phenomenon and its clinical relevance are not defined. This article reviews available clinical data on the effect of cardiac surgery on endogenous stem cells and outlines some of the controversies in this area.

Tissue engineering and biotechnology in general thoracic surgery

“…SC therapy of lymphoproliferative diseases is an established method of challenging a permanent interaction between the graft and the host [46]. Theoretically, in case of more complex organs, an implanted micro-size tissue can be followed by a controlled growth to full size under the supervision of the surrounding tissue microenvironment and additionally administered growth and differentiation factors.…”

Stem/Progenitor Cells, Atherosclerosis and Cardiovascular Regeneration

“…Recent reports have shown involvement of Notch and sphingosine-1 phosphate system signaling in the activation of CXCR4 under conditions of tissue ischemia [68]. Clinical studies have demonstrated, that cardiovascular surgical intervention had mobilizing effect on CD34+, CD34+CXCR4+ cells and increased number of circulating CFU progenitor cells [69].…”

Editorial: Inflammation, Thrombosis and Vascular Biology: Translating Ideas into Cardiovascular Research and Therapy

“…It was shown that chronic inflammation interferes with the process of endothelial regeneration and, thereby, contributes to endothelial dysfunction [26]. Attempts were made to use bone marrow derived stem cells for therapeutic purposes in several cardiovascular disorders [27]. Whether this approach will be also useful in chronic inflammatory disorders is not clear.…”