NSAIDs and Hormone Replacement Therapy in Geriatric Crohnʼs Disease

Systematic review with meta‐analysis: association between acetaminophen and nonsteroidal anti‐inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation

“…conducted a case–control study in 33 IBD patients with symptom flares and 23 IBD patients in clinical remission as controls, no statistically significant difference in the frequency of NSAIDs use was observed between cases and controls. Similarly, Riley et al and Jejuna et al in their respective cohort studies on UC and CD did not find significant difference in NSAIDs use among patients with active disease and those in remission.…”

“…Nine studies evaluated IBD complications in quiescent disease ranging from symptomatic relapses confirmed on sigmoidoscopy and disease flares requiring steroids to emergency admissions . Nine studies examined worsening disease activity level using physician global assessment of disease activity or objective indices like Harvey‐Bradshaw, Manitoba or Mayo scores . The number of participants per study ranged from 60 to 1940 for a total of 6276 participants across studies pooled for the meta‐analysis.…”

“…All analyses were performed using STATA Mayo scores. 8,9,[28][29][30][31][32][33][34] The number of participants per study ranged from 60 to 1940 for a total of 6276 participants across studies pooled for the meta-analysis. Thirteen studies were included in the meta-analysis, five cohort 9,23,25,27,29 and 8 case-control studies.…”