NSAID chronotherapy after impacted third molar extraction: a randomized controlled trial

Tamimi, Zaid; Abusamak, Mohammad; Al-Waeli, Haider; Al-Tamimi, Mohammad; Habashneh, Rola Al; Ghanim, Mohammad; Al-Nusair, Mohammed; Gao, Qiman; Nicolau, Belinda; Tamimi, Faleh

doi:10.1007/s10006-021-01029-8

Cited by 6 publications

(7 citation statements)

References 61 publications

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“…Furthermore, NSAIDs chronotherapy (i.e. morning and afternoon administration only) was reported to be of potential therapeutic benefit for post-operative recovery after wisdom tooth extraction (Tamimi et al 2022). This finding was also in accordance with a recent study, published after our search was conducted, investigating the same outcomes but in a cross-over design (Pérez-González et al 2022).…”

Section: Discussionsupporting

confidence: 87%

“…In the included case report treating oral pemphigus vulgaris, Waghmare and Puthenveetil (2021) showed that a single dose of prednisolone at 06:00 h achieved complete remission of the oral lesion as opposed to conventional regimen (twice daily), which 50% reduction only. Tamimi et al (2022) conducted an RCT evaluating the effect of chronotherapy of NSAIDs on post-operative recovery in a third molar extraction model. They concluded that restricting ibuprofen administration to daytime (morning and afternoon) might be as sufficient as conventional administration regimens (morning, afternoon and evening) in controlling postoperative pain after third molar extraction (Tamimi et al 2022).…”

Section: Prosthodontics and Oral Medicinementioning

confidence: 99%

“…Tamimi et al (2022) conducted an RCT evaluating the effect of chronotherapy of NSAIDs on post-operative recovery in a third molar extraction model. They concluded that restricting ibuprofen administration to daytime (morning and afternoon) might be as sufficient as conventional administration regimens (morning, afternoon and evening) in controlling postoperative pain after third molar extraction (Tamimi et al 2022).…”

Section: Prosthodontics and Oral Medicinementioning

confidence: 99%

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Chronotherapy in dentistry: A scoping review

Abusamak

Al-Tamimi

Al-Waeli

et al. 2023

Chronobiology International

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The circadian clock modulates almost all vital aspects of our physiology and metabolism, including processes relevant to dentistry, such as healing, inflammation and nociception. Chronotherapy is an emerging field aiming to improve therapeutic efficacy and decrease adverse effects on health outcomes. This scoping review aimed to systematically map the evidence underpinning chronotherapy in dentistry and to identify gaps in knowledge. We conducted a systematic scoping search using four databases (Medline, Scopus, CINAHL and Embase). We identified 3908 target articles screened by two blinded reviewers, and only original animal and human studies investigating the chronotherapeutic use of drugs or interventions in dentistry were included. Of the 24 studies included, 19 were human studies and five were animal studies. Chrono-radiotherapy and chrono-chemotherapy reduced treatment side effects and improved therapeutic response, leading to higher survival rates in cancer patients. Animal studies reported that tooth movement and periodontal tissue response to orthodontic forces follow a diurnal rhythm that might influence bone metabolism. Profound and prolonged local anesthesia could be achieved when injected in the evening. Although the overall quality of the included studies was low, chronotherapy applications in dentistry seem to have favourable outcomes, especially in head and neck cancer treatments.

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Section: Discussionsupporting

confidence: 87%

Section: Prosthodontics and Oral Medicinementioning

confidence: 99%

Section: Prosthodontics and Oral Medicinementioning

confidence: 99%

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Chronotherapy in dentistry: A scoping review

Abusamak

Al-Tamimi

Al-Waeli

et al. 2023

Chronobiology International

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“…Recently a similar study was performed comparing the effect of chronotherapy of the NSAIDs, finding no differences in terms of trismus or swelling indicator and pain scores between the experimental and the control group. They also considered that the night intake of NSAID do not provide any potential benefit in the post-surgical lower third molar treatment [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Pérez-González

Abusamak

Sáez-Alcaide

et al. 2022

Oral Maxillofac Surg

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Purpose To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model. Methods Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively. Results Postoperative swelling and pain perception did not show significative difference between the control and experimental groups at 24, 48, and 72 h. Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0.008). Rescue medication consumption seemed to be comparable between groups. Conclusion Eliminating night time ibuprofen might be insignificant for pain control after third molar extraction.

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“…Ñëåäîâàòåëüíî, âàaeíåéøèì ðåñóðñîì ïîâûøåíèÿ áåçîïàñíîñòè ÍÏÂÑ ÿâëÿåòñÿ ñòðîãîå ñîáëþäåíèå èíñòðóêöèé ê èõ ïðèìåíåíèþ. Ðàöèîíàëüíûì ÿâëÿåòñÿ ñíèaeåíèå äîçû ËÑ ëèáî çà ñ÷åò èñïîëüçîâàíèÿ ýôôåêòà ïîòåíöèðîâàíèÿ (íàïðèìåð, êîìáèíàöèÿ ñî ñïàçìîëèòèêàìè), ëèáî çà ñ÷åò ó÷åòà áèî-ëîãè÷åñêèõ ðèòìîâ áîëè [83]. Äðóãîé ïðèíöèïèàëüíûé ïîäõîä ê îïòèìèçàöèè ñâîéñòâ ÍÏÂÑ -ìîäèôèêàöèÿ èçâåñòíûõ ìîëåêóë ñ ïîëó÷åíèåì äîïîëíèòåëüíûõ, ïàòîãå-íåòè÷åñêè îáîñíîâàííûõ ñâîéñòâ.…”

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Побочные Эффекты Нестероидных Противовоспалительных Средств И Пути Их Профилактики

Олейникова¹,

Сереброва²,

Кононова³

et al. 2022

Эксп. и клин. фармакол.

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Нестероидные противовоспалительные средства входят в число наиболее часто назначаемых лекарственных средств. Существует тенденция к еще более широкому их применению в клинической практике в связи с увеличением средней продолжительности жизни и обременением населения возраст-ассоциированными заболеваниями, в первую очередь, с болевым синдромом. При этом альтернативных обезболивающих средств, не вызывающих зависимость и имеющих доказанную эффективность, пока нет. Однако данные многочисленных исследований и мета-анализов свидетельствуют о побочных эффектах нестероидных противовоспалительных средств, включающих желудочно-кишечные, сердечно-сосудистые, печеночные, почечные, церебральные и легочные осложнения. В обзоре представлены современные представления о механизмах основных и побочных эффектов нестероидных противовоспалительных средств и последних разработках в отношении снижения их органотоксичности (химическая модификация фармакофоров). Приведенные сведения будут полезны при оценке соотношения риска и пользы в рациональном использовании нестероидных противовоспалительных средств в более безопасной дозе и продолжительности.

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NSAID chronotherapy after impacted third molar extraction: a randomized controlled trial

Cited by 6 publications

References 61 publications

Chronotherapy in dentistry: A scoping review

Chronotherapy in dentistry: A scoping review

Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial

Побочные Эффекты Нестероидных Противовоспалительных Средств И Пути Их Профилактики

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