NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer

Marzioni, Daniela; Mazzucchelli, Roberta; Fantone, Sonia; Tossetta, Giovanni

doi:10.1007/s11033-022-08052-2

Cited by 27 publications

(35 citation statements)

References 57 publications

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“…Curcumin is an important anti-inflammatory and antioxidant compound playing a key role in many cellular processes, including inhibition of STAT3 activation in nonimmune cells, such as adipocytes and trophoblast cells; inhibition of NF-kB activation in pregnancy complications; and activation of the NRF2/KEAP1 pathway [ 145 , 146 , 147 , 148 ]. Campbell et al demonstrated that polyphenols, such as carnosol and curcumin, can decrease glycolysis and spare respiratory capacity in LPS-induced DC stimulation, via AMPK activation and mTOR signaling inhibition.…”

Section: Resultsmentioning

confidence: 99%

“…Vitamin E (tocopherol) plays an important role as a potent lipid-soluble antioxidant agent in immune cells, which is found in higher concentrations, being one of the most effective nutraceuticals to modulate immunometabolism [ 163 ]. Moreover, this nutraceutical vitamin E plays an important anticancer activity, modulating the NRF2/KEAP1 pathway [ 148 ]. Vitamin E presents a protective role, acting against oxidation of membrane PUFAs, due to their high metabolic activity and their defensive function [ 163 ].…”

Section: Resultsmentioning

confidence: 99%

“…This nutraceutical shows a powerful anti-inflammatory effect [ 168 ]. Furthermore, this molecule is an important antioxidant and anticancer agent, preventing cancer occurrence and improving the chemotherapy response [ 148 , 169 ]. Regarding immunometabolism, SFN may inhibit the release of NO, COX-2, iNOS, TNF-α, IL-6, and IL-1β in LPS-stimulated macrophages [ 170 ].…”

Section: Resultsmentioning

confidence: 99%

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Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

et al. 2023

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Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of physiological processes. In an inflammatory microenvironment, these functional foods can interact with the immune system by modulating or balancing the exacerbated proinflammatory response. In this process, immune cells, such as antigen-presenting cells (APCs), identify danger signals and, after interacting with T lymphocytes, induce a specific effector response. Moreover, this conditions their change of state with phenotypical and functional modifications from the resting state to the activated and effector state, supposing an increase in their energy requirements that affect their intracellular metabolism, with each immune cell showing a unique metabolic signature. Thus, nutraceuticals, such as polyphenols, vitamins, fatty acids, and sulforaphane, represent an active option to use therapeutically for health or the prevention of different pathologies, including obesity, metabolic syndrome, and diabetes. To regulate the inflammation associated with these pathologies, intervention in metabolic pathways through the modulation of metabolic energy with nutraceuticals is an attractive strategy that allows inducing important changes in cellular properties. Thus, we provide an overview of the link between metabolism, immune function, and nutraceuticals in chronic inflammatory processes associated with obesity and diabetes, paying particular attention to nutritional effects on APC and T cell immunometabolism, as well as the mechanisms required in the change in energetic pathways involved after their activation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

et al. 2023

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“…In addition to tumorigenesis, the upregulation of p62 was also associated with cancer progression and therapeutic resistance [ 114 ]. It should be mentioned that a variety of natural and synthetic compounds, such as γ-tocopherol (γ-TmT) and sulforaphane (SFN), could elevate the expression of Nrf2 to protect cells from oxidative stress, thereby significantly reducing the incidence of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice [ 115 ]. Taken together, drugs targeting the p62/Keap1/Nrf2 signaling pathway, such as p62 inhibitors and Nrf2 modulators have potential to become new strategies for tumor treatment.…”

Section: Indirect Redox Regulation Of Autophagy In Cancermentioning

confidence: 99%

Redox Regulation of Autophagy in Cancer: Mechanism, Prevention and Therapy

Dong

Luo

et al. 2022

Life

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Reactive oxygen species (ROS), products of normal cellular metabolism, play an important role in signal transduction. Autophagy is an intracellular degradation process in response to various stress conditions, such as nutritional deprivation, organelle damage and accumulation of abnormal proteins. ROS and autophagy both exhibit double-edged sword roles in the occurrence and development of cancer. Studies have shown that oxidative stress, as the converging point of these stimuli, is involved in the mechanical regulation of autophagy process. The regulation of ROS on autophagy can be roughly divided into indirect and direct methods. The indirect regulation of autophagy by ROS includes post-transcriptional and transcriptional modulation. ROS-mediated post-transcriptional regulation of autophagy includes the post-translational modifications and protein interactions of AMPK, Beclin 1, PI3K and other molecules, while transcriptional regulation mainly focuses on p62/Keap1/Nrf2 pathway. Notably, ROS can directly oxidize key autophagy proteins, such as ATG4 and p62, leading to the inhibition of autophagy pathway. In this review, we will elaborate the molecular mechanisms of redox regulation of autophagy in cancer, and discuss ROS- and autophagy-based therapeutic strategies for cancer treatment.

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“…The pathological processes resulting in ALI can be divided into inflammatory exudative, lung tissue proliferation, and lung fibrosis phases, although the pathogenesis is generally more complex than this. The Keap1/Nrf2 signaling pathway has been found to be associated with cancers such as breast, lung, and colon cancers, among others [10][11][12][13]. The Keap1/Nrf2/ARE pathway regulates the transcription of many antioxidants to maintain cellular homeostasis and prevent the organism from harm.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo

Shi

Xiao

Dong

et al. 2022

IJMS

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Acute lung injury (ALI) is a syndrome caused by an excessive inflammatory response characterized by intractable hypoxemia both inside and outside the lung, for which effective therapeutic drugs are lacking. Atractylodis rhizoma, a traditional Chinese medicine, has excellent anti-inflammatory and antiviral properties in addition to protecting the integrity of the cellular barrier. However, few studies of Atractylodis rhizoma for the treatment of ALI have been published, and its mechanism of action remains unclear. In the present study, the chemical composition of the ethanolic extract of Atractylodis rhizoma (EEAR) was initially clarified by high performance liquid chromatography (HPLC), after which it was studied in vivo using a lipopolysaccharide (LPS)-induced ALI rat model. Treatment with EEAR significantly reduced the lung wet/dry (W/D) ratio, neutrophil infiltration, and malondialdehyde (MDA) and myeloperoxidase (MPO) formation, and enhanced superoxide dismutase (SOD) and glutathione (GSH) depletion in rats with ALI, thereby improving lung barrier function and effectively reducing lung injury. In addition, EEAR significantly reduced histopathological changes, decreased the expression of inflammatory factors (such as tumor necrosis factor-α (TNF-α), interleukin-1 beta (IL-1β), inducible nitric oxide synthase (INOS), and cyclooxygenase-2 (COX-2)), and inhibited the activation of the NF-κB signaling pathway, thus reducing inflammation. In addition, EEAR was found to also reduce oxidative stress in ALI by upregulating the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream proteins heme oxygenase-1 (HO-1) and NADPH quinone acceptor oxidoreductase 1 (NQO-1). EEAR also reduced LPS-induced inflammatory factor expression in THP-1 cells in vitro by inhibition of the NF-κB signaling pathway, and reduced damage from lipopolysaccharide (LPS)-induced oxidative stress in THP-1 cells by promoting the expression of Nrf2 and its downstream targets HO-1 and NQO-1, the molecular mechanism of which was consistent with in vivo observations. Therefore, we conclude that EEAR attenuates oxidative stress and inflammatory responses via TLR4/NF-κB and Keap1/Nrf2 signaling pathways to alleviate LPS-induced ALI, suggesting that Atractylodis Rhizoma is a potential drug candidate for the treatment of ALI.

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NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer

Cited by 27 publications

References 57 publications

Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

Redox Regulation of Autophagy in Cancer: Mechanism, Prevention and Therapy

Protective Effects of Atractylodis lancea Rhizoma on Lipopolysaccharide-Induced Acute Lung Injury via TLR4/NF-κB and Keap1/Nrf2 Signaling Pathways In Vitro and In Vivo

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