Nrf2 gene promoter polymorphism was associated with ulcerative colitis in female subjects

Arisawa, Tomiyasu; Wang, F; Tahara, T; Shibata, Takeshi; Nakamura, Masaki; Nagasaka, Mitsuo; Takahama, Kazuya; Watanabe, M. A. E.; Hirata, Ichiro; Nakano, Hirofumi

doi:10.1097/00054725-200705001-00023

Cited by 13 publications

(12 citation statements)

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“…The inflammation scores in the carriers were significantly lower than those in the non-A/G carriers, suggesting that the Ϫ686/Ϫ684 haplotype is associated with the development of gastric inflammation and gastric carcinogenesis (Arisawa et al, 2008a). In a separate study with 89 Japanese patients with ulcerative colitis and 141 healthy volunteers, the Ϫ686*-684 genotype of Nrf2 was suggested to be associated with the development of ulcerative colitis (Arisawa et al, 2008b).…”

Section: Human Polymorphismmentioning

confidence: 97%

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

2012

Pharmacol Rev

282

252

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Section: Human Polymorphismmentioning

confidence: 97%

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

2012

Pharmacol Rev

282

252

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“…In observational studies, a polymorphism in NFE2L2 was associated with reduced transcriptional activity correlating with increased risk of inflammatory bowel disease (Arisawa et al, 2008b) and chronic gastritis (Arisawa et al, 2007). One example of the immune modulatory action of NRF2 is provided in the central nervous system.…”

Section: A Key Role Of Nuclear Factor (Erythroid-derived 2)-like 2 Imentioning

confidence: 99%

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

et al. 2018

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“…Thus, the NRF2-ARE pathway plays a crucial role in protection against oxidative stress at an early stage. In humans, single-nucleotide polymorphisms (SNPs) in the promoter region of NRF2 are thought to be associated with the risk of acute lung injury, ulcerative colitis and gastritis, as shown in epidemiological studies [12][13][14]. Considering the possible contribution of oxidative stress to colorectal cancer in humans, as mentioned above, clarification of the effects of inactivation of NRF2 on lesions is important for assessment of the risk of colorectal cancer in individuals with SNPs in NRF2.…”

Section: Introductionmentioning

confidence: 99%

Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice

et al. 2016

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To assess the risk of colorectal cancer in humans with inactivation of NRF2, Nrf2‐proficient (Nrf2 +/+) and ‐deficient (Nrf2 −/−) mice were exposed to potassium bromate (KBrO3) at concentrations of 750 or 1500 ppm for 52 weeks. Neoplastic proliferative lesions were observed in the small intestine and exhibited accumulations of β‐catenin and cyclin D1. The lesions had characteristics similar to those in experimental models of human hereditary colorectal cancer. An additional 13‐week study was performed to examine the role of Nrf2 in the effects of oxidative stress. Significant increase in combined incidences of preneoplastic and neoplastic lesions in Nrf2 −/− mice administered high‐dose KBrO3. In the short‐term study, although 8‐hydroxydeoxyguanosine (8‐OHdG) levels in the epithelial DNA of Nrf2 −/− mice at the high dose were significantly lower than those of the corresponding Nrf2 +/+ mice, the difference was very small. mRNA levels of Nrf2‐regulated genes were increased in Nrf2 +/+ mice. Overexpression of cyclooxygenase 2 (COX2) and increased numbers of proliferating cell nuclear antigen (PCNA)‐positive cells in the jejunal crypts were observed in Nrf2 −/− mice administered high‐dose KBrO3. Overall, these data suggested that individuals having single‐nucleotide polymorphisms in NRF2 may have a risk of colorectal cancer to some extent.

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Nrf2 gene promoter polymorphism was associated with ulcerative colitis in female subjects

Cited by 13 publications

References 0 publications

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice

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