Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Ma, Qiang; He, Xiaoqing

doi:10.1124/pr.110.004333

Cited by 282 publications

(265 citation statements)

References 231 publications

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“…A growing body of evidence has indicated that Nrf2 protects animals from cancer, chronic inflammation, neurodegeneration, and chemical toxicity, which are marked with prominent oxidative stress (Kensler et al, 2007;Ma, 2010;Taguchi et al, 2011;Ma and He, 2012). Given the protective role of Nrf2 in diseases associated with oxidative damage, we postulate that Nrf2 directly controls the ROS metabolism and redox state of cells in addition to drug metabolism and cytoprotective functions.…”

Section: Discussionmentioning

confidence: 99%

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Redox Regulation by Nuclear Factor Erythroid 2-Related Factor 2: Gatekeeping for the Basal and Diabetes-Induced Expression of Thioredoxin-Interacting Protein

2012

Mol Pharmacol

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Section: Discussionmentioning

confidence: 99%

“…The nuclear factor erythroid 2-related factor 2 (Nrf2) has recently emerged as a critical regulator of resistance to ROS and electrophiles (Kensler et al, 2007;Ma, 2008;Taguchi et al, 2011;Ma and He, 2012). Nrf2 protects against glucose toxicity in cardiomyocytes by inhibiting ROS production ).…”

Section: Introductionmentioning

confidence: 99%

Redox Regulation by Nuclear Factor Erythroid 2-Related Factor 2: Gatekeeping for the Basal and Diabetes-Induced Expression of Thioredoxin-Interacting Protein

2012

Mol Pharmacol

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“…93 ), Maf-lacking 81 , selective bZip domain complex inhibitors (impede interaction between Nrf2 -ARE interaction) (ref. 90 ) and RNA interference (Nrf2 translation blocking) (ref. 93 ).…”

Section: Nrf2 Inhibitorsmentioning

confidence: 99%

“…These inducers can be endogenous (NO, H 2 O 2 , 4-maleylacetoacetate, 4-hydroxynonenal, nitro-oleic acid, 15-deoxy-delta-12,14-prostaglandin J2) or exogenous, including phytochemicals (quercetin, oleanolic acid, genistein 90 , resveratrol, sulphoraphan 89 , curcumin 91 , Au(I), silica, nanotubes) (ref. 90 ). The gene encoding Nrf2 is regulated by KGF (cytoprotective factor for epithelial cells) (ref.…”

Section: Nrf2 Inductorsmentioning

confidence: 99%

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

Ambrožová¹,

Ulrichová²,

Galandáková³

2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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a,bNrf2 and NF-κB transcription factors act in wound healing via their anti-inflammatory and anti-oxidant effects or through the immune response. Studying this process is a matter of some importance given the high cost of wound treatment. A major contribution in this regard is being made by models that enable investigation of the involvement of multiple factors in wound healing and testing new curative substances. This literature review was carried out via searches in the PubMed and Web of Science databases up to 2016. It covers skin wound healing, available models for its study (part I), the role of Nrf2 and NF-κB, substances that influence them and whether they can be used as markers (part II). Was found that in vitro assays are used for their availability but a holistic view must be established in vivo. In silico approaches are facilitating assessment of a vast amount of research data. Nfr2 and NF-κB play a crucial and reciprocal role in wound healing. Nrf2 controls repair-associated inflammation and protects against excessive accumulation of ROS while Nf-κB activates the innate immune reaction, proliferation and migration of cells, modulates expression of matrix metalloproteinases, secretion and stability of cytokines and growth factors for wound healing.

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“…NRF2 is a Cap'N'Collar (CNC) transcription factor that contains a basic leucine-zipper (bZIP) domain [9]. Under a basal condition, NRF2 is sequestered in the cytoplasm and constantly poly-ubiquitinated by an E3 ubiquitin ligase adaptor, Kelch-like ECH-associated protein-1 (KEAP1).…”

Section: Introductionmentioning

confidence: 99%

Ethanol Extracts of Rheum undulatum and Inula japonica Protect Against Oxidative Damages on Human Keratinocyte HaCaT cells through the Induction of ARE/NRF2-dependent Phase II Cytoprotective Enzymes

Yoo¹,

이용걸²,

도기환³

et al. 2017

Journal of Life Science

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Mammalian cells control cellular homeostasis using a variety of defensive enzymes in order to combat against environmental oxidants and electrophiles. NF-E2-related factor-2 (NRF2) is a transcription factor that, in response to an exposure to oxidative stress, translocates into the nucleus and modulates the inducible expression of various phase II cytoprotective enzymes by binding to the antioxidant response element (ARE). In the present study, we have acquired 400 ethanol extracts of traditional medicinal plants and attempted to find out possible extract(s) that can increase the NRF2/ARE-dependent gene expression in human keratinocytes. As a result, we have identified that ethanol extracts of Rheum undulatum and Inula japonica strongly activated the ARE-dependent luciferase activity in HaCaT-ARE-luciferase cells. Exposure of ethanol extracts of Rheum undulatum and Inula japonica increased the viability and activated transcription and translation of NRF2-dependent phase II cytoprotective enzymes in HaCaT cells, such as heme oxygenase-1 (HO-1) and NAD[P]H:quinone oxidorecutase-1 (NQO1). In addition, ethanol extracts of Rheum undulatum and Inula japonica suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced generation of intracellular reactive oxygen species (ROS), thereby inhibiting the formation of 8-hydroxyguanosine (8-OHG) and 4-hydroxynonenal (4-HNE) in HaCaT cells. Together, our results demonstrate that ethanol extracts of Rheum undulatum and Inula japonica exert anti-oxidant effects via the induction of NRF2/ARE-dependent gene expression in human keratinocytes.

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Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Cited by 282 publications

References 231 publications

Redox Regulation by Nuclear Factor Erythroid 2-Related Factor 2: Gatekeeping for the Basal and Diabetes-Induced Expression of Thioredoxin-Interacting Protein

Redox Regulation by Nuclear Factor Erythroid 2-Related Factor 2: Gatekeeping for the Basal and Diabetes-Induced Expression of Thioredoxin-Interacting Protein

Models for the study of skin wound healing. The role of Nrf2 and NF-κB

Ethanol Extracts of Rheum undulatum and Inula japonica Protect Against Oxidative Damages on Human Keratinocyte HaCaT cells through the Induction of ARE/NRF2-dependent Phase II Cytoprotective Enzymes

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