NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice

Mena, María A.; Casarejos, Marı́a José; Solano, Rosa M.; Rodríguez-Navarro, José Antonio; Gómez, Ana; Rodal, Izaskun; Medina, Miguel; Yébenes, Justo Garcı́a de

doi:10.1016/j.febslet.2008.11.051

Cited by 12 publications

(10 citation statements)

References 42 publications

(86 reference statements)

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“…In addition, NP7 could inhibit microglial activation, and prevented the increased phosphorylation of ERK induced by H 2 O 2 . Therefore, NP7 may be developed as a neuroprotective agent against oxidative stress in PD [13,14].…”

Section: Potential Candidates From Marine-derived Compounds For Thmentioning

confidence: 99%

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

2019

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Parkinson’s disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons, leading to the motor dysfunctions of patients. Although the etiology of PD is still unclear, the death of dopaminergic neurons during PD progress was revealed to be associated with the abnormal aggregation of α-synuclein, the elevation of oxidative stress, the dysfunction of mitochondrial functions, and the increase of neuroinflammation. However, current anti-PD therapies could only produce symptom-relieving effects, because they could not provide neuroprotective effects, stop or delay the degeneration of dopaminergic neurons. Marine-derived natural compounds, with their novel chemical structures and unique biological activities, may provide anti-PD neuroprotective effects. In this study, we have summarized anti-PD marine-derived natural products which have shown pharmacological activities by acting on various PD targets, such as α-synuclein, monoamine oxidase B, and reactive oxygen species. Moreover, marine-derived natural compounds currently evaluated in the clinical trials for the treatment of PD are also discussed.

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Section: Potential Candidates From Marine-derived Compounds For Thmentioning

confidence: 99%

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

2019

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“…Antioxidative properties are easily assayed in HTS formats measuring the reactive oxygen species (ROS) formed in cell-based assays [164] or in chemical assays such as the α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method [165] and oxygen radical absorbance capacity (ORAC) method [166]. One marine-derived antioxidant, NP7, has been reported to be a potent free radical scavenging agent and to protect neuronal and glial cultures from H 2 O 2 -induced cell death [167]. …”

Section: Methodologies Of Screeningmentioning

confidence: 99%

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

et al. 2018

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The increase of many deadly diseases like infections by multidrug-resistant bacteria implies re-inventing the wheel on drug discovery. A better comprehension of the metabolisms and regulation of diseases, the increase in knowledge based on the study of disease-born microorganisms’ genomes, the development of more representative disease models and improvement of techniques, technologies, and computation applied to biology are advances that will foster drug discovery in upcoming years. In this paper, several aspects of current methodologies for drug discovery of antibacterial and antifungals, anti-tropical diseases, antibiofilm and antiquorum sensing, anticancer and neuroprotectors are considered. For drug discovery, two different complementary approaches can be applied: classical pharmacology, also known as phenotypic drug discovery, which is the historical basis of drug discovery, and reverse pharmacology, also designated target-based drug discovery. Screening methods based on phenotypic drug discovery have been used to discover new natural products mainly from terrestrial origin. Examples of the discovery of marine natural products are provided. A section on future trends provides a comprehensive overview on recent advances that will foster the pharmaceutical industry.

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“…NP7 suppressed microglial activation and the H 2 O 2 -induced dropout of DA neurons. The authors indicated that NP7 might be a promising neuroprotecting agent against oxidative stress in PD [123]. …”

Section: Antioxidant Compounds In Experimental Models Of Pdmentioning

confidence: 99%

Recent Advances on the Neuroprotective Potential of Antioxidants in Experimental Models of Parkinson’s Disease

Koppula

Kumar

et al. 2012

IJMS

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Parkinson’s disease (PD), a neurodegenerative movement disorder of the central nervous system (CNS) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain. Although the etiology of PD is not completely understood and is believed to be multifactorial, oxidative stress and mitochondrial dysfunction are widely considered major consequences, which provide important clues to the disease mechanisms. Studies have explored the role of free radicals and oxidative stress that contributes to the cascade of events leading to dopamine cell degeneration in PD. In general, in-built protective mechanisms consisting of enzymatic and non-enzymatic antioxidants in the CNS play decisive roles in preventing neuronal cell loss due to free radicals. But the ability to produce these antioxidants decreases with aging. Therefore, antioxidant therapy alone or in combination with current treatment methods may represent an attractive strategy for treating or preventing the neurodegeneration seen in PD. Here we summarize the recent discoveries of potential antioxidant compounds for modulating free radical mediated oxidative stress leading to neurotoxicity in PD.

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NP7 protects from cell death induced by oxidative stress in neuronal and glial midbrain cultures from parkin null mice

Cited by 12 publications

References 42 publications

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

Current Screening Methodologies in Drug Discovery for Selected Human Diseases

Recent Advances on the Neuroprotective Potential of Antioxidants in Experimental Models of Parkinson’s Disease

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