Noxiousness Valuation of Two Pharmaceutical Plants on White Garden Snail and Their Side Influences on Biochemical Parameters and Histopathological Changes in Brown Rat

Abstract

The current study aimed to evaluated the toxicity of Abrus precatorius (AP) and Ricinus communis (RC) plants on land snail (Theba pisana) and their effects on biochemical and histological changes in brown rat (Rattus norvegicus). Different concentration (1%, 1.5%, 2% and 2.5%) of AP and RC were used in this study to evluate their effects. The findings of this study pertained that the seeds of AP and RC had potential impact to control T. pisana and the LC50 of AP and RC had negative effects on many life cycle stages of T. pisana. The oviposition and new generation of T. pisana decreased by 81.2% and 62.5% and by 100% and 96.7%, while the infertility rate declined by 96.4% and 82.4% after treating T. pisana by AP and RC, respectively. Results also showed that AP and RC had weak influences on the liver, spleen, intestine, kidney and testis tissues of R. norvegicus. Furthermore, the effect was relatively higher for A. precatorius than R. communis on R. norvegicus males.