NOX4 promotes mucosal barrier injury in inflammatory bowel disease by mediating macrophages M1 polarization through ROS

Han, Chenyang; Sheng, Yongjia; Wang, Jin; Zhou, Xin; Li, Wenyan; Zhang, Caiqun; Li, Guo; Yang, Yi

doi:10.1016/j.intimp.2021.108361

“…NADPH oxidase 4 (NOX4) is one of the primary sources of reactive oxygen species (ROS) and increases nitric oxide synthases (NOS) expressions in IBD, which can promote the polarization of intestinal macrophages toward the M1 phenotype. In vitro experiments, the inhibition of NOX4 expression into co-cultured Caco2 cells and M1 macrophages resulted in decreased IECs barrier permeability and increased TEER values, which not only reduced epithelial cell death but also increased the expression of ligand proteins [63]. These results indicate that NOX4 can promote M1 polarization of intestinal macrophages via ROS to further aggravate intestinal inflammation and mucosal barrier damage in IBD [63].…”

Section: Interaction Between Macrophage Polarization and The Intestin...mentioning

confidence: 86%

Macrophage polarization in inflammatory bowel disease

Zhang,

Guo,

Yan

et al. 2023

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The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding of IBD diagnosis and therapeutic approaches. The pathogenesis of IBD has not been fully elucidated; however, the combined actions of environmental, genetic, immune factors, and microbial organisms are believed to cause IBD. In the innate immune system, macrophages play important roles in maintaining intestinal health and in the development of IBD. Macrophages can be polarized from M0 into several phenotypes, among which M1 and M2 play critical roles in IBD development and the repair of intestinal homeostasis and damage. Certain macrophage-related IBD studies already exist; however, the functions of each phenotype have not been fully elucidated. As technology develops, understanding the link between macrophages and IBD has increased, including the growing knowledge of the developmental origins of intestinal macrophages and their performance of comprehensive functions. This review describes macrophage polarization in IBD from the perspectives of macrophage development and polarization, macrophage changes in homeostasis and IBD, metabolic changes, and the mechanisms of macrophage polarization in IBD. The discussion of these topics provides new insights into immunotherapy strategies for IBD.

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“…On the contrary, other studies focused on murine intestinal macrophages abundantly found in inflammatory bowel diseases and expressing various phenotypes. They revealed that NOX4 inhibitor suppressed the M1 polarization of intestinal macrophages, reducing the proportion of F4/80 + CD11c + macrophages and inflammatory cytokines levels [ 58 ]. We can assume that these divergent results of NOX4 inhibition relate with the macrophages lineage and that NOX4 may act on distinct differentiation and polarization stages.…”

Section: Macrophages Polarization: Role Of Ros and Noxsmentioning

confidence: 99%

Wound Healing versus Metastasis: Role of Oxidative Stress

López

¹

,

Wendremaire

²

,

Lagarde

³

et al. 2022

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Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophages-released ROS arise as major regulators of these processes. But, whatever the pathology concerned, oxidative stress is a complicated phenomenon to control and requires a finely tuned balance over the different stages and responding cells. This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages. Indeed, macrophages are major ROS producers but also appear as their targets since ROS interfere with their differentiation and function. Elucidating ROS functions in wound healing and metastatic spread may allow the development of innovative therapeutic strategies involving redox modulators.

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“…On the contrary, other studies focused on murine intestinal macrophages abundantly found in inflammatory bowel diseases and expressing various phenotypes. They revealed that NOX4 inhibitor suppressed the M1 polarization of intestinal macrophages, reducing the proportion of F4/80 + CD11c + macrophages and inflammatory cytokines levels [28]. We can assume that these divergent results of NOX4 inhibition relate with the macrophages lineage and that NOX4 may act on distinct differentiation and polarization stages.…”

Section: Noxs In Macrophages Polarizationmentioning

confidence: 99%

Wound Healing Versus Metastasis: Role of Oxidative Stress

López¹,

Wendremaire²,

Lagarde³

et al. 2022

Preprint

4

0

View full text Add to dashboard Cite

Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophages-released ROS arise as major regulators of these processes. But, whatever the pathology concerned, oxidative stress is a complicated phenomenon to control and requires a finely tuned balance over the different stages and responding cells. This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages. Indeed, macrophages are major ROS producers but also appear as their targets since ROS interfere with their differentiation and function. Elucidating ROS functions in wound healing and metastatic spread may allow the development of innovative therapeutic strategies involving redox modulators.

show abstract

NOX4 promotes mucosal barrier injury in inflammatory bowel disease by mediating macrophages M1 polarization through ROS

Cited by 23 publications

References 15 publications

Macrophage polarization in inflammatory bowel disease

Macrophage polarization in inflammatory bowel disease

Wound Healing versus Metastasis: Role of Oxidative Stress

Wound Healing Versus Metastasis: Role of Oxidative Stress

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