Abstract:Surgical treament and/or amphotericin B have been the treatment of choice for cerebral infections caused by the fungus Paracoccidioides brasiliensis 1,3,6,7,8,9,11,12,13,15,17 . We are reporting a new drug treatment for the encephalic form of paracoccidioidomycosis. P. brasiliensis, the agent of a deep fungal infection highly endemic in Central and South America, has been associated with two types of CNS lesions: granuloma reaction in the meninges, frequently causing a ba silar leptomeningitis similar to tube… Show more
Cerebral and cerebellar masses occurred in patients with paracoccidioidomycosis. Correct diagnosis was delayed due to overlooking the abnormal lung roentgenograms and the history of previous disease in a different localization. The fungus was identified through biopsy and direct examination of the samples. In two patients necropsy confirmed the diagnosis. None of the patients responded to amphotericin B or cotrimoxazole. A 10 year English and Latin American literature review on neuroparacoccidioidomycosis was performed through a MEDLINE and LILACS (Latin American Literature Search System) data base systems.
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