Novel wet electrospinning system for fabrication of spongiform nanofiber 3-dimensional fabric

Yokoyama, Yoshiro; Hattori, Satoshi; Yoshikawa, Chiaki; Yasuda, Yuji; Koyama, Hiroyuki; Takato, Tsuyoshi; Kobayashi, Haruo

doi:10.1016/j.matlet.2008.12.042

Cited by 146 publications

(80 citation statements)

References 17 publications

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“…It was also considered that the wet electrospinning process might lead to less inter-fiber bonding, which would also ease cell migration and contribute to scaffold softening. Quite recently there has been a brief report in the literature [38] where another “wet” electrospinning technique was used. In that method, electrospun fibers were directly deposited onto fluid surfaces of varying surface tension to form scaffolds of increased porosity, and as in our method, apparently increased fiber tortuosity.…”

Section: Discussionmentioning

confidence: 99%

Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold

et al. 2010

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Although a variety of materials are currently used for abdominal wall repair, general complications encountered include herniation, infection, and mechanical mismatch with native tissue. An approach wherein a degradable synthetic material is ultimately replaced by tissue mechanically approximating the native state could obviate these complications. We report here on the generation of biodegradable scaffolds for abdominal wall replacement using a wet electrospinning technique in which fibers of a biodegradable elastomer, poly(ester urethane)urea (PEUU), were concurrently deposited with electrosprayed serum-based culture medium. Wet electrospun PEUU (wet ePEUU) was found to exhibit markedly different mechanical behavior and to possess an altered microstructure relative to dry processed ePEUU. In a rat model for abdominal wall replacement, wet ePEUU scaffolds (1 × 2.5 cm) provided a healing result that developed toward approximating physiologic mechanical behavior at 8 wks. An extensive cellular infiltrate possessing contractile smooth muscle markers was observed together with extensive extracellular matrix (collagens, elastin) elaboration. Control implants of dry ePEUU and expanded polytetrafluoroethylene did not experience substantial cellular infiltration and did not take on the native mechanical anisotropy of the rat abdominal wall. These results illustrate the markedly different in vivo behavior observed with this newly reported wet electrospinning process, offering a potentially useful refinement of an increasingly common biomaterial processing technique.

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Section: Discussionmentioning

confidence: 99%

Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold

et al. 2010

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“…For bone tissue engineering, a large 3D scaffold may be required. While new processing techniques have shown promise to increase the size and porosity of electrospun scaffolds[34], more work needs to be done to further the architectural control. Having pores large enough for not only cell penetration, but vascular ingrowth is imperative for a vascularized tissue such as bone.…”

Section: Scaffold Fabricationmentioning

confidence: 99%

Biomimetic nanofibrous scaffolds for bone tissue engineering

2011

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Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most challenging bone-related clinical issues. The major components of bone tissue engineering are the scaffold, cells, and growth factors. This review will focus on the scaffold and recent advancements in developing scaffolds that can mimic the natural extracellular matrix of bone. Specifically, these novel scaffolds mirror the nanofibrous collagen network that comprises the majority of the non-mineral portion of bone matrix. Using two main fabrication techniques, electrospinning and thermally-induced phase separation, and incorporating bone-like minerals, such as hydroxyapatite, composite nanofibrous scaffolds can improve cell adhesion, stem cell differentiation, and tissue formation. This review will cover the two main processing techniques and how they are being applied to fabricate scaffolds for bone tissue engineering. It will then cover how these scaffolds can enhance the osteogenic capabilities of a variety of cell types and survey the ability of the constructs to support the growth of clinically relevant bone tissue.

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“…The modification is based on the usage of a liquid collector instead of a solid, mostly metallic one. Wet electrospinning was first introduced in [1,2] as a method for the lab-scale production of nanofibrous scaffolds for tissue engineering. To produce bulky and fluffy material using the common electrospinning method is a tricky matter.…”

Section: Introductionmentioning

confidence: 99%

Study of polycaprolactone wet electrospinning process

Košťáková¹,

Seps²,

Pokorný³

et al. 2014

Express Polym. Lett.

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Abstract. Wet electrospinning is a useful method for 3-dimensional structure control of nanofibrous materials. This innovative technology uses a liquid collector instead of the metal one commonly used for standard electrospinning. The article compares the internal structural features of polycaprolactone (PCL) nanofibrous materials prepared by both technologies. We analyze the influence of different water/ethanol compositions used as a liquid collector on the morphology of the resultant polycaprolactone nanofibrous materials. Scanning electron micro-photographs have revealed a bimodal structure in the wet electrospun materials composed of micro and nanofibers uniformly distributed across the sample bulk. We have shown that the full-faced, twofold fiber distribution is due to the solvent composition and is induced and enhanced by increasing the ethanol weight ratio. Moreover, the comparison of fibrous layers morphology obtained by wet and dry spinning have revealed that beads that frequently appeared in dry spun materials are created by Plateau-Rayleigh instability of the fraction of thicker fibers. Theoretical conditions for spontaneous and complete immersion of cylindrical fibers into a liquid collector are also derived here.

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Novel wet electrospinning system for fabrication of spongiform nanofiber 3-dimensional fabric

Cited by 146 publications

References 17 publications

Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold

Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold

Biomimetic nanofibrous scaffolds for bone tissue engineering

Study of polycaprolactone wet electrospinning process

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