Novel volatiles of skin-borne bacteria inhibit the growth of Gram-positive bacteria and affect quorum-sensing controlled phenotypes of Gram-negative bacteria

Lemfack, Marie Chantal; Ravella, Srinivasa Rao; Lorenz, Nicola; Kai, Marco; Jung, Kirsten; Schulz, Stefan; Piechulla, Birgit

doi:10.1016/j.syapm.2016.08.008

Cited by 34 publications

(32 citation statements)

References 72 publications

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“…Derivatives of phenylpyruvate metabolism are methyl benzoate and acetophenone. Schleiferons are released from Staphylococcus schleiferi and biosynthesized by 2-phenylethylamine and acetoin (Lemfack et al, 2016;Kai et al, 2018).…”

Section: Biosynthesis Of Mvocsmentioning

confidence: 99%

Volatilomes of Bacterial Infections in Humans

Elmassry

Piechulla

2020

Front. Neurosci.

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Sense of smell in humans has the capacity to detect certain volatiles from bacterial infections. Our olfactory senses were used in ancient medicine to diagnose diseases in patients. As humans are considered holobionts, each person's unique odor consists of volatile organic compounds (VOCs, volatilome) produced not only by the humans themselves but also by their beneficial and pathogenic micro-habitants. In the past decade it has been well documented that microorganisms (fungi and bacteria) are able to emit a broad range of olfactory active VOCs [summarized in the mVOC database (http://bioinformatics.charite.de/mvoc/)]. During microbial infection, the equilibrium between the human and its microbiome is altered, followed by a change in the volatilome. For several decades, physicians have been trying to utilize these changes in smell composition to develop fast and efficient diagnostic tools, particularly because volatiles detection is non-invasive and non-destructive, which would be a breakthrough in many therapies. Within this review, we discuss bacterial infections including gastrointestinal, respiratory or lung, and blood infections, focusing on the pathogens and their known corresponding volatile biomarkers. Furthermore, we cover the potential role of the human microbiota and their volatilome in certain diseases such as neurodegenerative diseases. We also report on discrete mVOCs that affect humans.

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Section: Biosynthesis Of Mvocsmentioning

confidence: 99%

Volatilomes of Bacterial Infections in Humans

Elmassry

Piechulla

2020

Front. Neurosci.

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“…Consideration must be given to the potential network of VOC-mediated interspecies communication that can influence and modulate the local microbiota, and in turn, affect cutaneous health. In this regard, Lemfack and co-workers investigated the volatile profiles of the 2 dominant families of skin microbiota, namely Staphylococcaceae and Corynebacteriaceae [78]. VOCs were collected in cell cultures using an adsorbent trap with subsequent solvent extraction and analysis by GC-MS.…”

Section: Investigating Volatile Profiles In Different Skin Commensal mentioning

confidence: 99%

Endogenous and microbial volatile organic compounds in cutaneous health and disease

Duffy

Morrin

2019

TrAC Trends in Analytical Chemistry

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Human skin is a region of high metabolic activity where a rich variety of biomarkers are secreted from the stratum corneum. The skin is a constant source of volatile organic compounds (VOCs) derived from skin glands and resident microbiota. Skin VOCs contain the footprints of cellular activities and thus offer unique insights into the intricate processes of cutaneous physiology. This review examines the growing body of research on skin VOC markers as they relate to skin physiology, whereby variations in skin-intrinsic and microbial metabolic processes give rise to unique volatile profiles. Emerging evidence for volatile biomarkers linked to skin perturbations and skin cancer are examined. Microbial-derived VOCs are also investigated as prospective diagnostic markers, and their potential to shape the composition of the local skin microbiota, and consequently cutaneous health, is considered. Finally, a brief outlook on emerging analytical challenges and opportunities for skin VOC-based research and diagnostics is presented.

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“…toxins), antibiotic resistance and spore germination in competing microorganisms (i.e. bacteria, fungi) [22][23][24][25][26][27]. For example, some Streptomyces species surpass obstacles by so-called 'explorer cells', whereby they colonize new areas in the face of competition induced by the biogenic volatile trimethylamine [28].…”

Section: Chemical Diversity and Natural Functions Of Microbial Volatimentioning

confidence: 99%

“…For example, some Streptomyces species surpass obstacles by so-called 'explorer cells', whereby they colonize new areas in the face of competition induced by the biogenic volatile trimethylamine [28]. The skin-borne Staphyloccoccus schleiferi produces schleiferons A and B that modulate the skin microbiome possibly by inhibiting the growth of Gram-positive bacteria and by interfering with prodiginines production [26]. Plants also respond to and utilize MVCs leading to growth promotion or inhibition, induced systemic resistance or alteration of the plant metabolome [11,29,30].…”

Section: Chemical Diversity and Natural Functions Of Microbial Volatimentioning

confidence: 99%

“…For example, VCs from yeasts such as 3methyl-1-butanol disrupt the fungal membrane by increasing the peroxidation levels of membrane lipids, thereby causing a non-selective permeability of the plasma membrane[50].Other modes of action comprise the interference of MVCs with cell-to-cell communication or quorum sensing. The aforementioned schleiferon A and B inhibit quorum sensing, thereby reducing the expression of prodigiosin and bioluminescence in Gram-negative bacteria[26].…”

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Healthy scents: microbial volatiles as new frontier in antibiotic research?

Ávalos

Wezel

Raaijmakers

et al. 2018

Current Opinion in Microbiology

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Microorganisms represent a large and still resourceful pool for the discovery of novel compounds to combat antibiotic resistance in human and animal pathogens. The ability of microorganisms to produce structurally diverse volatile compounds has been known for decades, yet their biological functions and antimicrobial activities have only recently attracted attention. Various studies revealed that microbial volatiles can act as infochemicals in long-distance cross-kingdom communication as well as antimicrobials in competition and predation. Here, we review recent insights into the natural functions and modes of action of microbial volatiles and discuss their potential as a new class of antimicrobials and modulators of antibiotic resistance.

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Novel volatiles of skin-borne bacteria inhibit the growth of Gram-positive bacteria and affect quorum-sensing controlled phenotypes of Gram-negative bacteria

Cited by 34 publications

References 72 publications

Volatilomes of Bacterial Infections in Humans

Volatilomes of Bacterial Infections in Humans

Endogenous and microbial volatile organic compounds in cutaneous health and disease

Healthy scents: microbial volatiles as new frontier in antibiotic research?

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