Novel useful markers for follow-up of necrotizing enterocolitis: endocan and interleukin-33

Çakır, Ufuk; Tayman, Cüneyt; Yarcı, Erbu; Halil, Halid; Büyüktiryaki, Mehmet; Ulu, Hülya Özkan; Yücel, Çiğdem; Oğuz, Şerife Suna

doi:10.1080/14767058.2018.1548601

Cited by 23 publications

(19 citation statements)

References 34 publications

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“…In particular, the study of Çakır et al [14] in infants with necrotizing enterocolitis showed that the endocan increased signi cantly in showing the severity of the disease, opening a new window. The most important nding in the study of Sakuraba et al [15] in 133 patients with ulcerative colitis was that the extent of the disease may affect the correlation between fecal biomarker values. Especially in patients with proctitis, the low correlation between stool biomarkers and endoscopic ndings, just as in our study, shows that both endocan and fecal calprotectin are more valuable in cases of extensive disease.…”

Section: Discussionmentioning

confidence: 99%

A novel inflammatory indicator in extensive ulcerative colitis; Endocan?

Albayrak

Şebin

2022

Preprint

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Background and study aim Ulcerative colitis (UC) is an inflammatory bowel disease characterized by mucosal inflammation that starts from the rectum (distal) and extends proximally, involving the entire colon (pancolitis). In this study, we aimed to evaluate the usability of endocan level in determining the extent and severity of disease in patients with ulcerative colitis and to determine whether it can be a candidate marker for noninvasive evaluation and monitoring since there is not enough data in the literature. Materials and Methods Sixty-five people were included in the study, including thirty-five with ulcerative colitis and thirty in the control group. patients with newly diagnosed ulcerative colitis clinically, endoscopically, and histopathologically, without any treatment, and with normal liver and kidney tests were included in the study. Endoscopic scoring of all patients was performed according to the mayo endoscopic scoring (MES) system. Blood samples for CRP (C-reactive protein) and endocan were taken from the patients simultaneously. Results There was a significant statistical difference between all patients with ulcerative colitis and the control group in both endocan level and CRP level (p < 0.001). There was a statistically significant difference between endocan levels and CRP levels between the left-distal group and pancolitis (diffuse colitis) patients, but there was no statistical difference between age and MES. Conclusion Serum endocan level can be a useful test in determining the extent and severity of ulcerative colitis, making hospitalization decisions, and planning treatment. Stool markers may not always be available due to patient compliance.

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Section: Discussionmentioning

confidence: 99%

A novel inflammatory indicator in extensive ulcerative colitis; Endocan?

Albayrak

Şebin

2022

Preprint

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“…The expression level of inflammatory cytokines such as IL-6 was correlated with the severity of NEC (34). Previous studies have been indicated that higher IL-6 levels were detected in the plasma and stools of NEC patients in the follow-up (35). Moreover, IL-6 levels were corrected with disease severity and can be used to monitoring the progress of NEC (36,37).…”

Section: Discussionmentioning

confidence: 96%

Peptide Tat(48–60) YVEEL protects against necrotizing enterocolitis through inhibition of toll-like receptor 4-mediated signaling in a phosphatidylinositol 3-kinase/AKT dependent manner

et al. 2022

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Necrotizing enterocolitis (NEC) is a catastrophic disease largely occurring in preterm infants, and toll-like receptor 4 (TLR4) has been implicated in its pathogenesis. The current therapeutic strategies for NEC are, however, far from optimal. In the present study, a whey-derived antioxidative peptide conjugated with a cell-penetrating TAT [Tat (48–60) YVEEL] was prepared to endow it with enhanced cell uptake capability and bioavailability. The protective effect of Tat (48–60) YVEEL on experimental NEC was evaluated both in vitro and in vivo. Inhibition of TLR4-mediated signaling by Tat (48–60) YVEEL was assessed in FHC and IEC-6 enterocytes, neonatal rat model of NEC, and the mechanism underlying this effect was determined. Tat (48–60) YVEEL significantly inhibited TLR4-mediated expression of pro-inflammatory cytokines, p65 nuclear translocation and restored the impaired enterocyte migration in cultured enterocytes. In addition, Tat (48–60) YVEEL administration strikingly increased the survival rate, and reduced the severity of NEC in rats through inhibition of TLR4-mediated signaling. These protective effects of Tat (48–60) YVEEL occurred in a PI3K/AKT dependent manner, as administration of PI3K activator Ys49 abrogated its protective effects. Combined with liposomes, Tat (48–60) YVEEL demonstrated longer retention in the intestines that better for potential clinical applications. These data demonstrate that Tat (48–60) YVEEL protects against NEC through inhibition of TLR4-mediated signaling in a PI3K/AKT dependent manner, and offer a potential therapeutic approach to this disease.

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“…[41][42][43][44][45][46][47][48][49] In pediatric populations, recent studies reported high serum endocan levels in patients with necrotizing enterocolitis and juvenile idiopathic arthritis in the neonatal period. 50,51 But to the best of our knowledge, there is no study in a pediatric population assessing the risk of atherosclerosis in obese patients using endocan and cIMT.…”

Section: Discussionmentioning

confidence: 99%

Increased Carotid Intima–Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children

et al. 2021

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Obesity in children appears to be associated with increased risk of cardiovascular and metabolic diseases later in life. Early development of insulin resistance (IR) may lead to endothelial dysfunction and increased carotid intima–media thickness (cIMT) even in childhood. We compared endothelial cell-specific molecule-1 (endocan) levels in pediatric obese patients with those in healthy controls to determine whether endocan could be used as a biological marker of complications caused by endothelial damage. In 80 obese pubertal children (44 males [M] and 36 females [F], mean age: 12.8 ± 2.5 years), anthropometric measurements, cIMT, endocan levels, and IR indices (homeostasis model assessment of insulin resistance [HOMA-IR]) were evaluated and compared with 80 healthy pubertal patients (42M/38F, mean age: 12.3 ± 3.2 years). High-resolution ultrasound was used to measure the cIMT. Obese children had higher levels of endocan compared with the controls ( P < .001). Fasting insulin levels and HOMA-IR were also higher in obese children ( P < .001 for both). In addition, obese children had an increased cIMT ( P < .001). In obese children, there was a significant correlation between cIMT and HOMA-IR (β = −1.314, P = .002) and between cIMT and endocan (β = .483, P = .004). Measuring cIMT and endocan levels (noninvasive investigations) in obese children, together with early preventive measures, could significantly decrease morbidity and mortality in adulthood.

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Novel useful markers for follow-up of necrotizing enterocolitis: endocan and interleukin-33

Cited by 23 publications

References 34 publications

A novel inflammatory indicator in extensive ulcerative colitis; Endocan?

A novel inflammatory indicator in extensive ulcerative colitis; Endocan?

Peptide Tat(48–60) YVEEL protects against necrotizing enterocolitis through inhibition of toll-like receptor 4-mediated signaling in a phosphatidylinositol 3-kinase/AKT dependent manner

Increased Carotid Intima–Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children

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