Novel use of propranolol for management of pain in children with vertebral hemangioma: report of two cases

Abstract

Propranolol is a beta blocker which is safely used in the management of infantile hemangiomas. This is the first report demonstrating its efficacy in symptomatic treatment of childhood VH. The lesions did not show any regression, but the pain relief obtained was very significant under propranolol therapy.

Aggressive vertebral hemangiomas in asymptomatic patients: A review

“…[5] In the fourth case (e.g., 4th study), Uzunaslan et al described using propranolol to treat T5 aggressive hemangioma. [6] Patient 8 years of age, without epidural invasion, improved within 2 months. On repeat magnetic resonance imaging scan, 18 months later, the lesion did not decrease in size [6] [Table 2].…”

“…[6] Patient 8 years of age, without epidural invasion, improved within 2 months. On repeat magnetic resonance imaging scan, 18 months later, the lesion did not decrease in size [6] [Table 2].…”

“…Only 4 of 89 articles met the inclusion criteria for this the study [Table 2]. [2,3,5,6] Patients undergoing surgery, embolizations, or radiotherapy, were excluded from the study.…”

“…Of the four initially asymptomatic patients, two later required emergent surgery within an average follow-up period of 28 months. [3,6] DISCUSSION e natural history for aggressive hemangiomas was described by four authors and involved just four patients.…”

Development of a reversed‐phase high‐performance liquid chromatographic method for the determination of propranolol in different skin layers

“…Currently, this condition is treated by oral administration of PPN, causing side effects (Padula, Nicoli, Pescina, & Santi, 2019). Recently, some studies have shown the potent effect of PPN as a local anesthetic, similar to lidocaine, which suggests the possible exploration of this drug for local skin delivery (Chen, Chiu, Wei, Hung, & Wang, 2015; Uzunaslan et al, 2013).…”