Novel trypanocide from an extract of
            <i>Pleurotus sajor-caju</i>
            against
            <i>Trypanosoma congolense</i>

Ademola, Isaiah Oluwafemi; Odeniran, Paul Olalekan

doi:10.1080/13880209.2016.1230878

Cited by 11 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phytochemicals present in fruiting bodies, mycelia and spores include phenolic (gallic acid, catechin, isoquercetin, kaempferol), saponins, flavonoids, tannins, alkaloids, quinolones, terpenes, and anthraquinones (18,19). Other primary metabolites present are peptides, steroids, benzoic derivatives, ascorbic acid, amino acids and oxalic acids (20,21).…”

Section: Introductionmentioning

confidence: 99%

Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild DriedLentinus squarrosulus(Mont.) Mushroom in Rats

et al. 2019

View full text Add to dashboard Cite

Lentinus squarrosulus (Mont.) is an edible wild mushroom with tough fruiting body that belongs to the family Polyporaceae. It is used in ethnomedicine for the treatment of ulcer, anaemia, cough and fever. Recent studies have demonstrated its anticancer, anti-diabetic and antioxidant properties. However, little or no information is available regarding the bioactive components and toxicological study of wild dried L. squarrosulus . Therefore, this study investigated the bioactive components of aqueous extract of boiled wild dried L. squarrosulus and its toxicological effects in rats. The extract of L. squarrosulus was subjected to GC-MS analysis. The acute toxicity test was performed by oral administration of a single dose of up to 5,000 mg/kg extract of L. squarrosulus . In subacute study, the rats were orally administered extract of L. squarrosulus at the doses of 500, 1,000 and 1,500 mg/kg body weight daily for 14 days. The haematological, lipid profile, liver and kidney function parameters were determined and the histopathology of the liver and kidney were examined. The GC-MS analysis revealed the presence of bioactive compounds; 1-tetradecene, fumaric acid, monochloride, 6-ethyloct-3-yl ester, 9-eicosene, phytol, octahydropyrrolo[1,2-a]pyrazine and 3-trifluoroacetoxypentadecane. In acute toxicity study, neither death nor toxicity sign was recorded. In the sub-acute toxicity study, significant differences ( p < 0.05) were observed on creatinine, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglycerides and high-density lipoprotein cholesterol. Whilst no significant differences ( p > 0.05) were observed on packed cell volume, heamoglobin, red blood cell, white blood cell and alkaline phosphatase, in all the tested doses. No histopathological alterations were recorded. Our findings revealed that aqueous extract of L. squarrosulus may have antimicrobial, antinocieptive and antioxidant properties based on the result of GC-MS analysis. Results of the toxicity test showed no deleterious effect at the tested doses, suggesting that L. squarrosulus is safe for consumption at the tested doses.

show abstract

Section: Introductionmentioning

confidence: 99%

Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild DriedLentinus squarrosulus(Mont.) Mushroom in Rats

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is nutritionally rich in protein, fibre, minerals and vitamins, and is low in calories with very low lipid or starch contents. This mushroom has also been widely used in traditional medicine because of its various bioactive properties, including antiviral (Teplyakova & Kosogova, 2016), antibacterial , antifungal (Alves et al, 2013), antiparasitic (Ademola & Odeniran, 2017), antitumor (Ferreira et al, 2015), antioxidant (Ferreira, Barros, & Abreu, 2009), antihypertensive (through active ingredients that affect the renin-angiotensin system) (Chang & Wasser, 2012), antidiabetic, preventing hyperglycemia and insulin resistance (Kanagasabapathy et al, 2012) and anti-inflammatory (Taofiq et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds

et al. 2018

View full text Add to dashboard Cite

A B S T R A C TA study with Pleurotus sajor-caju was conducted to: evaluate the nutritional and chemical composition of the fruiting bodies; optimize the preparation of bioactive phenolic extracts; and characterize the optimized extract in terms of bioactive compounds and properties. P. sajor-caju revealed an equilibrated nutritional composition with the presence of hydrophilic (sugars and organic acids) and lipophilic (tocopherols and PUFA) compounds. pHydroxybenzoic, p-coumaric and cinnamic acids were identified in the extract obtained with ethanol (30 g/l ratio) at 55°C for 85 min. This extract showed antioxidant properties (mainly reducing power and lipid peroxidation inhibition), antibacterial activity against MRSA and MSSA and cytotoxicity against NCI-H460, MCF-7 and HeLa. Furthermore, as the extract showed capacity to inhibit NO production in Raw 264.7 macrophages, molecular docking studies were performed to provide insights into the anti-inflammatory mechanism of action, through COX-2 inhibition by the phenolic acids identified.

show abstract

“…The challenge of trypanocidal resistance and increasing concern over drug residues in products from animal origin has led to resurgence of interest in the use of phytomedines, in the form of extracts containing a mixture of compounds (Ademola and Odeniran, 2017). This study investigates the efficacy of B. aegyptiaca and Suramin on T. evansi infected albino rats.…”

Section: Discussionmentioning

confidence: 99%

Trypanocidal effects of Balanites aegyptiaca Del. (Zygophyllaceae) Leaf ‎Extract and Suramin on Trypanosoma evansi Experimental Infection in ‎Albino rat

Abdullahi,

Malgwi,

Onyiche

et al. 2023

SJVS

View full text Add to dashboard Cite

TTrypanosoma evansi, is one among several species of Trypanosomes responsible for a major protozoan parasitic disease of domestic animals. The current study aimed to investigate the trypanocidal effects of aqueous and methanolic leaf extracts of Balanites aegyptiacaDel (Zygophyllaceae) and suramin on albino rats infected with Trypanosoma evansi. In total, 35 Swiss albino rats randomly separated into seven (7) groups (A- G) of 5 rats each were intraperitoneally infected with 0.5 ml of blood containing 1.0 × 106trypanosomes and treated with the extracts and suramin for 7 days and single dose respectively by day 12 post infection (p.i). Clinical parameters and haematological indices were evaluated. Preliminary phytochemical screening revealed that Balanitesaegyptiaca contained the following metabolites: flavonoids, tannin, saponins, alkaloids, glycosides, steroids and volatile oils. There was marked initial reduction in Packed Cell Volume (PCV), Haemoglobin (Hb) and Red Blood Cells (RBCs) counts in the infected/untreated group (Group A) but following treatment with B. aegyptiaca leaf aqueous and methanolic extracts, these values were reversed. Furthermore, there was reversion of leukopenia after treatment of the rats individually with methanolic leaf extracts (150 mg/kg of B. aegyptiaca; Group B) from 3.47±1.49 × 103/mm3 by day 12 p.i. to 9.03±2.18 by day 40 p.i., similar to the pre-infection value. In conclusion, the infection caused clinical and haematological changes that were ameliorated following treatment with methanolic and aqueous leaf extract of B. aegyptiaca

show abstract

Novel trypanocide from an extract of Pleurotus sajor-caju against Trypanosoma congolense

Abstract: Pleurotus sajor-caju therefore could be a potential source of new trypanocidal drugs.

Cited by 11 publications

References 27 publications

Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild DriedLentinus squarrosulus(Mont.) Mushroom in Rats

Toxicological Evaluation of Phytochemical Characterized Aqueous Extract of Wild DriedLentinus squarrosulus(Mont.) Mushroom in Rats

Multifunctions of Pleurotus sajor-caju (Fr.) Singer: A highly nutritious food and a source for bioactive compounds

Trypanocidal effects of Balanites aegyptiaca Del. (Zygophyllaceae) Leaf ‎Extract and Suramin on Trypanosoma evansi Experimental Infection in ‎Albino rat

Contact Info

Product

Resources

About