Novel treatment of atrophic rhinitis: early results

Jaswal, Abhishek; Jana, Avik Kumar; Sikder, Biswajit; Nandi, T.; Sadhukhan, Sanjoy Kumar; Das, Anjan

doi:10.1007/s00405-008-0629-5

Cited by 23 publications

(11 citation statements)

References 13 publications

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“…unter Zusatz von Glucose (bis 25 % ), Inhalationen von Sole und Schlafen bei off enem Fenster sind empfehlenswert [293] . Antibiotika werden bei purulenter Sekretion (Rifampicin: [294] ) [295] oder begleitend zu operativen Verfahren (Aminoglykoside: [296] ) eingesetzt, ohne aber die Erkrankung dauerhaft heilen zu k ö nnen [273] . Auch der Verschluss der Nasenl ö -cher mit z.…”

Section: Rhinitis Atrophicans Rhinitis Sicca Anterior Und Ozaenaunclassified

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Beule¹

2010

Laryngo-Rhino-Otol

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In this review, anatomy and physiology of the respiratory mucosa of nose and paranasal sinuses are summarized under the aspect of its clinical significance. Basics of endonasal cleaning including mucociliary clearance and nasal reflexes, as well as defence mechanisms are explained. Physiological wound healing, aspects of endonasal topical medical therapy and typical diagnostic procedures to evaluate the respiratory functions are presented. Finally, the pathophysiologies of different subtypes of non-allergic rhinitis are outlined together with treatment recommendations.

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Section: Rhinitis Atrophicans Rhinitis Sicca Anterior Und Ozaenaunclassified

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Beule¹

2010

Laryngo-Rhino-Otol

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“…Many factors are supposed to play a role such as infection by Klebsiella ozaenae, Staphylococcus aureus, Coccibacillus, Proteus mirabilis, Escherichia coli, Bacillus mucosus. But autoimmunity, chronic infection of the sinuses, endocrine factors, poor nutritional status, heredity and iron deficiency anemia are other possible contributing factors [1,2].…”

Section: Introductionmentioning

confidence: 99%

Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis

Huart

Eloy

Collet

et al. 2011

Eur Arch Otorhinolaryngol

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Atrophic rhinitis (AR) is a chronic inflammation of the nose characterized by an atrophy of the nasal mucosa. This is typically associated with an impaired sense of smell and a subjective sensation of poor nasal breathing. The aim of this study is to assess chemosensory function in patients suffering from AR using psychophysical testings and event-related potentials (ERP) responses. A cohort of nine patients was extensively studied. Eight out of nine had secondary AR sequela of a bilateral total inferior turbinectomy whereas one patient had a primary AR. All the patients had a clinical evaluation using Sniffin' Sticks test and a retro-olfaction test and an electrophysiological evaluation based upon ERPs obtained after both olfactory and trigeminal stimuli. All the patients complained of a poor nasal breathing and presented a distortion of the chemosensory function. Actually, the orthonasal psychophysical testing showed that four patients out of nine had anosmia, three out of nine had hyposmia and two out of nine were normosmic. All the patients demonstrated retro-olfaction scores inferior to the normal values. The chemosensory ERP showed that seven patients had no olfactory response whereas six had no trigeminal response. Four patients had neither olfactory nor trigeminal ERP response. In conclusion, this study demonstrates that most patients with AR secondary to a total bilateral inferior turbinectomy have a reduction of the chemosensory function measured objectively by psychophysical testings and ERP [corrected].

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“…Attempts of treating this nasal condition started as early as 1971, closure of the nostril (Young's operation 17 ) and endonasal microplasty (intranasal implant insertion),were the surgical management of primary AtR 18 , these options had its demerit on the possibility of decreased quality of life of the patient. Studies using rifampicin, cotrimoxazole and cipro oxacin for the disease 11,19,20 and found rifampicin to be the most effective treatment. In addition the use of lubricants like sesame oil in controlling the signs and symptoms of AtR was also attempted 21 .…”

Section: Discussionmentioning

confidence: 99%

Treatment of Atrophic Rhinitis with Manuka Honey–a non-randomized control trial, and a new theory of etiopathogenesis for the disease.

Sarkar

Purkait

Maiti

et al. 2021

Preprint

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Exact etiology of Atrophic rhinitis (AtR) is yet unknown. Polygenic and polybacterial causes have been implicated in the onset and progression of this disease. AtR doesn’t respond to any particular modality of treatment that targets specific etiology, this describes its multifactorial nature. In this study, we report on a non-randomized control trial on the use of a nasal spray of 10% Manuka honey in patients with AtR attending the out-patient unit of the Department of Otorhinolaryngology and Head Neck Surgery. In this study, we show significant observations: 1. Decreased fetid smell, 2. Thickening of the mucosa, 3. Decreased inflammation with healed mucosal ulcers, 4. Increased concentration of the mucosal glands, 5. Alteration in Nasal microbiome, and 6. Increased expression of SCFA receptors. These changes occurred in response to honey therapy, and are consequent to the resetting of the Nasal microbiome.

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Novel treatment of atrophic rhinitis: early results

Cited by 23 publications

References 13 publications

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Funktionen und Funktionsstörungen der respiratorischen Schleimhaut der Nase und der Nasennebenhöhlen

Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis

Treatment of Atrophic Rhinitis with Manuka Honey–a non-randomized control trial, and a new theory of etiopathogenesis for the disease.

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