Novel transition metal complexes of 4-hydroxy-coumarin-3-thiocarbohydrazone: Pharmacodynamic of Co(III) on rats and antimicrobial activity

Mosa, Aisha I.; Emara, Adel A.A.; Yousef, Jehad M.; Saddiq, Amna A.

doi:10.1016/j.saa.2011.05.035

Cited by 39 publications

(18 citation statements)

References 13 publications

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“…The frequency of the carbonyl oxygen in the spectra is shifted to lower frequencies due to the coordination of this atom to the metal ion in the range between 1675 and 1680 cm −1 , compared to the free ligand at 1695 cm −1 . A shift in the same way can also be observed for the azomethine group, which indicates that the nitrogens of these groups participate in the coordination [40]. Moreover, the band at 1000 cm −1 , which is attributed to the vibration ν (N–N) of the ligand, is shifted to higher wavenumbers (by ca.…”

Section: Resultsmentioning

confidence: 60%

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

2017

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A hydrazone Schiff base ligand was synthesized by the condensation of 3-formyl-4-hydroxycoumarin and oxalyldihydrazide in the molar ratio 2:1. The Schiff base ligand acts as a mono-, bi-, tri- or even tetradentate ligand with metal cations in the molar ratios 1:1 or 2:1 (M:L) to yield either mono- or binuclear complexes as keto or enol isomers, where M = Co(II), Ni(II), Cu(II), VO(IV), and Fe(III). The ligand and its metal complexes were characterized by elemental analyses, IR, 1H NMR, mass, and UV–Vis spectroscopy. Furthermore, the magnetic moments were calculated from the measured electric conductivities of the complexes. According to the received data, the dihydrazone ligand contains one or two units of ONO domains and can bind to the metal ions via the azomethine nitrogen, the carbonyl oxygen atoms, and/or the phenolic oxygen atoms. Electronic spectra and the magnetic moments of all complexes show that the complexes’ geometries are either octahedral, tetrahedral, square planar, or square pyramidal. Cyclic voltammograms of the mononuclear Co(II) and Ni(II) complexes show quasi-reversible peaks. Tests against two pathogenic bacteria as Gram-positive and Gram-negative bacteria for both, the Schiff base ligand and its metal complexes were carried out. In addition, also one kind of fungi was tested. The synthesized complexes demonstrate mild antibacterial and antifungal activities against these organisms.Graphical abstract Electronic supplementary materialThe online version of this article (doi:10.1007/s00706-017-2075-9) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 60%

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

2017

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“…The bands at 350 nm attributed to π-π*transitions of the C=N and C=O in addition to a broad band at 410nm due to the n π* transition which is overlapping with the intermolecular CT from the phenyl ring to the azomethine group [27]. Mass spectra were performed for HL Schiff base ligand to determine the molecular weights and fragmentation patterns.…”

Section: Schiff Base Hl Ligandmentioning

confidence: 99%

Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Mahmoud

Linert

2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Coumarins and 7‐hydroxycoumarins have also been found to show cytotoxic effects against lung adenocarcinoma cell lines . A series of stable transition metal complexes with 4‐hydroxycoumarin‐3‐thiocarbohydrazone ligand were characterized using various analytical techniques . Novel Ni(II), Co(II), Zn(II) and Mn(II) complexes of coumarin‐3‐carboxylic acid were studied at experimental and theoretical levels, and characterized using physicochemical tools .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, spectroscopic properties, density functional theory calculations and nonlinear optical properties of novel complexes of 5‐hydroxy‐4,7‐dimethyl‐6‐(phenylazo)coumarin with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal ions

Abdel‐Latif

Moustafa

2018

Applied Organom Chemis

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5-Hydroxy-4,7-dimethyl-6-(phenylazo)coumarin (L) has been synthesized and its novel complexes with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal ions have also been prepared and identified using various analytical tools. The complexes are octahedral binding via one/two oxygen, nitrogen atoms for 1:1 and 1:2 complexes and two/three coordinated water molecules. All the prepared solid complexes behave as neutral in dimethylformamide. The optimized structures of the studied complexes were theoretically investigated at the B3LYP/6-311G** level. Molecular stability and bond strengths were investigated by applying natural bond orbital analysis. The geometries of the studied complexes are non-planar as indicated from the values of dihedral angles. The global properties of hardness, global softness and electronegativity were computed. The calculated small energy gap between highest occupied and lowest unoccupied molecular orbital energies shows that charge transfer occurs within the complexes. The obtained total static dipole moment, mean polarizability, anisotropy of polarizability and mean first-order hyperpolarizability (<β>) were compared with those of urea as a reference material. The results for <β> showed that the complexes are excellent candidates as nonlinear optical materials. The three-dimensional plots of the molecular electrostatic potential for some selected complexes were investigated.

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Novel transition metal complexes of 4-hydroxy-coumarin-3-thiocarbohydrazone: Pharmacodynamic of Co(III) on rats and antimicrobial activity

Cited by 39 publications

References 13 publications

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

Syntheses, characterization, and biological activity of novel mono- and binuclear transition metal complexes with a hydrazone Schiff base derived from a coumarin derivative and oxalyldihydrazine

Synthesis, spectroscopic studies and inhibitory activity against bactria and fungi of acyclic and macrocyclic transition metal complexes containing a triamine coumarine Schiff base ligand

Synthesis, spectroscopic properties, density functional theory calculations and nonlinear optical properties of novel complexes of 5‐hydroxy‐4,7‐dimethyl‐6‐(phenylazo)coumarin with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal ions

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