Novel transition complexes of Co(II), Ni(II), Cu(II), and Zn(II) derived from 3-[p-(5-substituted salicylidinehydrazinocarbonyl)]phenylsydnone

Abstract

Schiff bases derived from 5-substituted salicylidine 3-[p-(5-substituted salicylidinehydrazinocarbonyl)]phenylsydnones and their transition metal complexes with Co(II), Ni(II), Cu(II), and Zn(II) have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibilities, electronic, infrared, Proton Magnetic Resonance (PMR) ( 1 H NMR), Fast Atomic Bombardment-(FAB)-mass spectra, Electron Spin Resonance (ESR), and thermal studies. From the above spectral studies, it is concluded that the ligands viz., 3-[p-(salicylidinehydrazinocarbonyl)]phenylsydnone (L 1 ); p-(vanillidine hydrazinocarbonyl)]phenylsydnone (L 2 ); and 3-[p-(5 0 chlorosalicylicdinehydrazinecarbonyl)]-phenylsydnones (L 3 ) act as bidentate molecules coordinating through azomethine nitrogen and phenolic oxygen. The ligands and their metal complexes have been screened in vitro for antibacterial, antifungal, and antitumor activities. The results indicate that the biological activity has increased on complexation. The Cu(II) complexes of the above-said ligands have proven to be antitumor agents toward the P388/s tumor cells at lower concentrations.

Coordination complexes involving sydnones as ligands

“…3). 38 Their approach was to combine both the sydnone moiety and a metal centre to obtain highly biologically active compounds. Even though XRD analysis was not reported on those complexes, their structure was deduced by measuring NMR, IR, ESR, electronic spectra as well as performing elemental analysis, thermogravimetric study (TGA and DTG), magnetic study and mass spectroscopy.…”