Schiff bases derived from 4-aminomethylcarbostyril and their transition metal complexes with Co II , Ni II , Cu II and Zn II have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibilities electronic, IR, PMR, ESR, FAB-Mass and thermal studies. From the above spectral studies it is concluded that the ligands of 4-substituted carbostyril Schiff bases, viz, salicylidene 4-aminomethylcarbostyril (SAMC); o-vanillinsalicylidene 4-aminomethylcarbostyril (VAMC) and 5¢ chlorosalicylidene 4-aminomethylcarbostyril (CSAMC) act as bidenate molecules coordinating through azomethine nitrogen and phenolic oxygen. The ligands and their metal complexes have been screened in vitro for antibacterial, antifungal and antitumor activity. The results indicate that the biological activity increases on complexation. The Cu II complexes of the above ligands show greater inhibitory action towards the P388/s tumor cells at lower concentrations.
Co(II), Ni(II), Cu(II), and Zn(II) complexes of the Schiff bases formed by the condensation of 8-formyl-7-hydroxy-4-methyl-coumarin with 3-amino-pyridine (L 1 ) and 3-amino-2-chloro-pyridine (L 2 ) are synthesized and characterized by various physico-chemical methods. The FAB-mass spectra of the ligand L 1 and its Zn(II) complex are reported herewith. Thermal studies with Co(II) and Ni(II) complexes of both the ligands L 1 and L 2 are also reported. From the above studies, it is concluded that the ligand L 1 acts as a bidentate ligand coordinating through azomethine nitrogen and phenolic oxygen of coumarin moiety via deprotonation, and ligand L 2 acts as a tridentate ligand coordinating through azomethine nitrogen, phenolic oxygen of coumarin, and chlorine of pyridine moiety. All the complexes showed an octahedral geometry with a slight distortion in Cu(II) complexes. The fluorescence studies are carried out for ligand L 1 with its Co(II), Ni(II), Cu(II), and Zn(II) complexes. The ligands and the complexes were screened for antibacterial and antifungal activities in vitro. The antitubercular activities are carried out by middle Brook method for all the compounds. The MIC values, cytotoxicity properties, and DNA cleavage studies are carried out for most active ligand L 2 , Co(II), and Cu(II) complexes.
A series of La(III), Ce(III), Pr(III), Nd(III), Sm(III), Eu(III), Gd(III) and Dy(III) complexes have been synthesized with Schiff bases derived from 4-aminomethylcarbostyril and substituted salicylaldehyde. The characterized involved elemental analyses, molar conductance, magnetic susceptibility, electronic, IR, NMR, mass and thermal studies. Spectral studies show all the Schiff bases behave as bidentate ligands and coordinate through the azomethine nitrogen and phenolic oxygen. The ligands and their metal complexes have been screened for their biological studies. The results indicate that the biological activity increases on complexation. The Lanthanium(III) complexes of the above ligands show greater inhibitory action towards the P388/s tumor cells at lower concentrations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.