Novel Transdermal Drug Delivery System with Polyhydroxyalkanoate and Starburst Polyamidoamine Dendrimer

WANG, ZHIOXIONG; Itoh, Yoshiaki; Hosaka, Yoshifumi; Kobayashi, Ichiro; Nakano, Yoshihisa; Maeda, Isamu; Umeda, Fusako; Yamakawa, Junji; Kawase, Masaya; Yagi, Kiyohito

doi:10.1263/jbb.95.541

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…In contrast, the dendrimer decreased the 5FU solubility in lipophilic vehicles and enhanced the drug K p . Similar to the results from the present study Wang et al20 reported a two fold increase in skin permeation of hydrophilic drug tamsulosin after pretreating snake skin with G4‐NH 2 dendrimer. However, the authors did not characterize the mechanism of permeation enhancement.…”

Section: Discussionsupporting

confidence: 92%

Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration

Venuganti

Perumal

2009

Journal of Pharmaceutical Sciences

129

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Section: Discussionsupporting

confidence: 92%

Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration

Venuganti

Perumal

2009

Journal of Pharmaceutical Sciences

129

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“…Wang et al110 reported the utilization of polyhydroxyalkanoate (PHA) and G3 PAMAM dendrimer as a novel TDDS. PHA used in this experiment was composed of 3‐hydroxyhexanoic acid (8%) and 3‐hydroxyoctanoic acid (92%).…”

Section: Applications In Different Routes Of Drug Administrationmentioning

confidence: 99%

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Cheng

et al. 2008

Journal of Pharmaceutical Sciences

409

188

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“…Although they exhibited promising results in the delivery of drugs such as tamsulosin [3], indomethacin [4], ketoprofen and diflunisal [5] and 5-fluorouracil [6], their biodegradation and inherent cytotoxicity is an issue that has to a large extent been overlooked [7].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments

Mutalik

Hewavitharana

Shaw

et al. 2009

Journal of Chromatography B

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a b s t r a c tThe aim of the present work was to develop and validate a simple RP-HPLC method with UV detection to quantify peptide dendrimers in skin permeation experiments. Six dendrimers of varying positive charges (4 + , 8 + and 16 + ) containing either histidine or arginine as terminal aminoacids were prepared by solid phase peptide synthesis. Mobile phase containing 0.02% (v/v) heptafluorobutyric acid in 90% acetonitrile-water was capable of separating all dendrimers from interfering peaks of receptor fluid. For the calibration of each dendrimer, a different dendrimer from the same class was selected as the internal standard. The results of preliminary human skin permeation studies showed that the developed analytical method can be successfully used for the quantification of cationic poly(aminoacid)-based dendrimers in skin permeation experiments.

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Novel Transdermal Drug Delivery System with Polyhydroxyalkanoate and Starburst Polyamidoamine Dendrimer

Cited by 10 publications

References 8 publications

Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration

Poly(amidoamine) dendrimers as skin penetration enhancers: Influence of charge, generation, and concentration

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments

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